prospero homeobox 1

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Synonym

Homeobox prospero-like protein PROX1, prospero-related homeobox 1, PROX1, PROX 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:16.60 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:355.90 eye:76.40 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:- spleen:18.90 thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.14 cerebellum:5.12 brain stem:5.09 corpus callosum/glia:5.46 pineal gland:- peripheral nerve:3.88 spine:4.96 retina:- eye:- artery/aorta:4.17 vein:4.54 lymphnode:5 peripheral blood:- spleen:5.97 thymus:3.97 bone marrow:4.18 adipose:4.67 bone:- skin:4.24
CAGE cerebrum:3.69 cerebellum:- brain stem:3.77 corpus callosum/glia:4.33 pineal gland:2.09 peripheral nerve:- spine:4.28 retina:- eye:- artery/aorta:2.08 vein:3.81 lymphnode:3.32 peripheral blood:- spleen:4.45 thymus:0.61 bone marrow:- adipose:1.51 bone:- skin:-
RNA-seq cerebrum:2.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.70 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.60 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:64.80 colon:33.90     liver/hepato:42.20        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:18.60 salivary:-
GeneChip uterus:4.17 placenta:4.20 prostate:4 ovary:4.52 testis:5.67 heart:5.64 muscle:4.72 esophagus:4.06 stomach:4.42 intestine:4.56 colon:4.49 liver/hepato:8.39 lung:4.27 bladder:- kidney:5.23 pituitary:5.27 thyroid/parathyroid:5.17 adrenal gland:5.21 pancreas:5.02 breast:4.18 salivary:4.33
CAGE uterus:2.44 placenta:0.99 prostate:2.37 ovary:3.00 testis:3.14 heart:3.85 muscle:2.99 esophagus:2.43 stomach:- intestine:2.79 colon:2.66     liver/hepato:5.50    lung:2.30 bladder:2.68 kidney:2.79 pituitary:4.15 thyroid/parathyroid:3.75 adrenal gland:- pancreas:4.14 breast:3.19 salivary:1.00
RNA-seq uterus:- placenta:- prostate:0.33 ovary:0.74 testis:1.80 heart:2.69 muscle:1.11 esophagus:- stomach:- intestine:- colon:0.39     liver/hepato:3.18        lung:0.48    bladder:- kidney:1.06 pituitary:- thyroid/parathyroid:1.41 adrenal gland:1.64 pancreas:- breast:0.19 salivary:-

Gene Information

IDs

Refseq ID NM_002763
Gene ID 5629
Unigene ID Hs.585369
Probe set ID 207401_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000117707
GTEx ID ENSG00000117707

Orthologous Gene

Mouse[2]  NM_008937
Rat[1]  NM_001107201

Chromosomal Region

1q32.3  [214,156,524  -  214,214,596]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8812486
10080188
11069920
11719431
11789987
11850194
11943779
12060670
12198161
12412020
12477932
12692551
12874782
15143342
15205472
15232737
15604093
16308102
16344560
16488887
16525637
17062673
17069925
17217617
17415710
17533110
17761831
18400094
18455124
18564921
18580962
18815287
18948102
19160541
19210544
19264593
19339011
19460752
19706680
19825936
19901262
19940551
20064070
20081858
20084020
20185807
20211142
20351309
20419449
20453716
20490451
20571754
20889853
20975337
21103350
21452064
21500548
21667034
21970873
21988832
22023334
22067331
22382784
22508481
22532251
22539871
22581228
22647876
22719258
22733308
22805777
22833470
22982861
22984506
22992776
23045246
23059885
23274905
23291986
23345397
23395615
23505027
23626788
23718855
23818313
23898075

Gene Ontology  (GO ID)

Biological Process

GO:0060414  aorta smooth muscle tissue morphogenesis
GO:0055009  atrial cardiac muscle tissue morphogenesis
GO:0007420  brain development
GO:0001709  cell fate determination
GO:0021707  cerebellar granule cell differentiation
GO:0021542  dentate gyrus development
GO:0021516  dorsal spinal cord development
GO:0060059  embryonic retina morphogenesis in camera-type eye
GO:0060214  endocardium formation
GO:0070365  hepatocyte differentiation
GO:0001822  kidney development
GO:0002088  lens development in camera-type eye
GO:0070309  lens fiber cell morphogenesis
GO:0001889  liver development
GO:0030324  lung development
GO:0001946  lymphangiogenesis
GO:0060836  lymphatic endothelial cell differentiation
GO:0030240  muscle thin filament assembly
GO:0070858  negative regulation of bile acid biosynthetic process
GO:0008285  negative regulation of cell proliferation
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0045071  negative regulation of viral genome replication
GO:0021915  neural tube development
GO:0030910  olfactory placode formation
GO:0046619  optic placode formation involved in camera-type eye
GO:0043049  otic placode formation
GO:0031016  pancreas development
GO:0045787  positive regulation of cell cycle
GO:0008284  positive regulation of cell proliferation
GO:0045737  positive regulation of cyclin-dependent protein kinase activity
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0060421  positive regulation of heart growth
GO:0060298  positive regulation of sarcomere organization
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0010468  regulation of gene expression
GO:0060849  regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0031667  response to nutrient levels
GO:0060042  retina morphogenesis in camera-type eye
GO:0048845  venous blood vessel morphogenesis
GO:0055010  ventricular cardiac muscle tissue morphogenesis
GO:0055005  ventricular cardiac myofibril development
GO:0060412  ventricular septum morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0050692  DBD domain binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0050693  LBD domain binding
GO:0016922  ligand-dependent nuclear receptor binding
GO:0005515  protein binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity