proteasome (prosome, macropain) subunit, alpha type, 1

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Synonym

Proteasome subunit alpha type 1, MGC22853, MGC14751, PROS30, Proteasome component C2, PROS-30, Multicatalytic endopeptidase complex subunit C2, Macropain subunit C2, PSMA1, MGC1667, MGC21459, MGC14542, PSC2, MGC23915, NU, MGC14575, 30 kDa prosomal protein, Proteasome nu chain

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:81.80 cerebellum:88.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:184 spine:- retina:- eye:94 artery/aorta:30 vein:199.90 lymphnode:111.20 peripheral blood:91.10 spleen:75.60 thymus:51.50 bone marrow:59 adipose:80.70 bone:38.40 skin:172.80
GeneChip cerebrum:8.49 cerebellum:8.55 brain stem:8.70 corpus callosum/glia:7.98 pineal gland:- peripheral nerve:8.87 spine:8.36 retina:- eye:- artery/aorta:8.74 vein:9.06 lymphnode:8.99 peripheral blood:- spleen:8.74 thymus:9.68 bone marrow:8.78 adipose:9.12 bone:- skin:9.20
CAGE cerebrum:4.66 cerebellum:- brain stem:4.57 corpus callosum/glia:4.29 pineal gland:4.48 peripheral nerve:- spine:4.59 retina:- eye:- artery/aorta:4.65 vein:4.64 lymphnode:4.82 peripheral blood:- spleen:4.90 thymus:4.90 bone marrow:- adipose:4.96 bone:- skin:-
RNA-seq cerebrum:1.36 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.20 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.81 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:131.10 prostate:191.50 ovary:111.80 testis:34.60 heart:140.50 muscle:341.50 esophagus:- stomach:63.70 intestine:129.60 colon:93.30     liver/hepato:221.70        lung:88    bladder:- kidney:72.80 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:177.80 breast:18.60 salivary:-
GeneChip uterus:9.20 placenta:9.12 prostate:9.45 ovary:9.25 testis:8.83 heart:9.03 muscle:9.71 esophagus:8.92 stomach:8.80 intestine:9.11 colon:8.70 liver/hepato:8.66 lung:9.11 bladder:- kidney:8.63 pituitary:8.78 thyroid/parathyroid:8.93 adrenal gland:8.87 pancreas:8.55 breast:8.90 salivary:8.65
CAGE uterus:4.78 placenta:5.03 prostate:4.76 ovary:4.65 testis:4.77 heart:4.91 muscle:5.15 esophagus:4.90 stomach:- intestine:4.82 colon:4.54     liver/hepato:5.04    lung:4.79 bladder:4.84 kidney:4.93 pituitary:4.90 thyroid/parathyroid:4.85 adrenal gland:- pancreas:4.63 breast:4.81 salivary:4.66
RNA-seq uterus:- placenta:- prostate:0.38 ovary:1.51 testis:0.62 heart:1.33 muscle:0 esophagus:- stomach:- intestine:- colon:0.59     liver/hepato:2.17        lung:1.29    bladder:- kidney:2.19 pituitary:- thyroid/parathyroid:1.97 adrenal gland:2.03 pancreas:- breast:1.27 salivary:-

Gene Information

IDs

Refseq ID NM_001143937
Gene ID 5682
Unigene ID Hs.102798
Probe set ID 211746_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000129084
GTEx ID ENSG00000129084

Orthologous Gene

Mouse[1]  NM_011965
Rat [0]  

Chromosomal Region

11p15.2  [14,515,329  -  14,665,181]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1398136
1517242
1660345
1888762
2025653
7681138
7811265
8206875
8811196
9079628
9311996
9451443
9464850
9497851
9811770
9846577
10068451
10799514
10893419
10983987
11205743
12150907
12167863
12376572
12419264
12477932
12719574
12750511
12808465
12808466
12809610
12830140
12840737
12859895
12914693
12920286
12970355
14527406
14528300
14528301
14550573
14557625
14564014
14614829
14733938
15225636
15489334
15831487
15887188
16169070
16189514
16196087
16344560
16503656
16713569
17203973
17292860
17314511
17323924
17353931
17506986
17573772
17623298
17948026
18029348
18654987
18854154
18922472
19013454
19056867
19060904
19193609
19349280
19596235
21139048
21145461
21565611
21703233
21733848
21832049
21853274
21890473
21906983
21963094
21987572
21988832
22053931
22079093
22190034
22268729
22505724
22623428
22863883
22939629
23000965
23393163
23438482
23503661
23535033
24040035
24429290
24654937
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0031145  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0006915  apoptosis
GO:0034641  cellular nitrogen compound metabolic process
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000082  G1/S transition of mitotic cell cycle
GO:0010467  gene expression
GO:0000278  mitotic cell cycle
GO:0016071  mRNA metabolic process
GO:0043066  negative regulation of apoptosis
GO:0051436  negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0051437  positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0000209  protein polyubiquitination
GO:0042981  regulation of apoptosis
GO:0006521  regulation of cellular amino acid metabolic process
GO:0051439  regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0016070  RNA metabolic process
GO:0016032  viral reproduction

Cellular Component

GO:0005813  centrosome
GO:0005829  cytosol
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005844  polysome
GO:0000502  proteasome complex
GO:0005839  proteasome core complex
GO:0019773  proteasome core complex, alpha-subunit complex

Molecular Function

GO:0005515  protein binding
GO:0003723  RNA binding
GO:0004298  threonine-type endopeptidase activity