dual specificity phosphatase 22

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Synonym

Dual specificity protein phosphatase 22, JSP1, dual specificity phosphatase 22, JSP-1, JKAP, MKPX, VHX, Mitogen-activated protein kinase phosphatase x, DUSP22, JNK-stimulatory phosphatase-1, LMW-DSP2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:45 cerebellum:12.60 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:17.60 artery/aorta:60 vein:- lymphnode:121.30 peripheral blood:91.10 spleen:170.20 thymus:77.30 bone marrow:78.70 adipose:80.70 bone:115.20 skin:72
GeneChip cerebrum:7.20 cerebellum:6.23 brain stem:7.26 corpus callosum/glia:7.42 pineal gland:- peripheral nerve:7.57 spine:7.35 retina:- eye:- artery/aorta:7.70 vein:7.43 lymphnode:7.83 peripheral blood:- spleen:7.99 thymus:7.14 bone marrow:7.07 adipose:7.59 bone:- skin:8.01
CAGE cerebrum:2.79 cerebellum:- brain stem:3.24 corpus callosum/glia:3.46 pineal gland:2.17 peripheral nerve:- spine:3.66 retina:- eye:- artery/aorta:3.61 vein:3.48 lymphnode:3.32 peripheral blood:- spleen:3.02 thymus:2.09 bone marrow:- adipose:3.51 bone:- skin:-
RNA-seq cerebrum:3.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.96 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:29.10 prostate:33.80 ovary:- testis:95.20 heart:63.90 muscle:- esophagus:- stomach:42.50 intestine:32.40 colon:25.40     liver/hepato:10.60        lung:53.80    bladder:125.60 kidney:20.80 pituitary:347.90 thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:65.10 salivary:-
GeneChip uterus:7.12 placenta:7.17 prostate:7.22 ovary:7.07 testis:8.53 heart:7.28 muscle:7.25 esophagus:8.08 stomach:7.38 intestine:7.36 colon:7.17 liver/hepato:7.10 lung:7.85 bladder:- kidney:6.74 pituitary:7.08 thyroid/parathyroid:7.65 adrenal gland:7.05 pancreas:7.59 breast:7.50 salivary:6.89
CAGE uterus:3.19 placenta:2.76 prostate:2.96 ovary:2.69 testis:2.63 heart:3.42 muscle:2.85 esophagus:3.44 stomach:- intestine:2.94 colon:3.30     liver/hepato:3.23    lung:3.40 bladder:3.03 kidney:2.85 pituitary:2.67 thyroid/parathyroid:3.25 adrenal gland:- pancreas:3.37 breast:3.66 salivary:2.75
RNA-seq uterus:- placenta:- prostate:4.03 ovary:3.32 testis:5.05 heart:3.11 muscle:3.61 esophagus:- stomach:- intestine:- colon:3.95     liver/hepato:3.23        lung:4.13    bladder:- kidney:3.21 pituitary:- thyroid/parathyroid:3.48 adrenal gland:4.10 pancreas:- breast:3.79 salivary:-

Gene Information

IDs

Refseq ID NM_020185
Gene ID 56940
Unigene ID Hs.29106
Probe set ID 218845_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000112679
GTEx ID ENSG00000112679

Orthologous Gene

Mouse[2]  NM_001037955, NM_134068
Rat[1]  NM_001108412, NM_134068

Chromosomal Region

6p25.3  [292,097  -  351,355]

Gene Family (Interpro ID)

IPR020417  Dual specificity phosphatase
IPR000340  Dual specificity phosphatase, catalytic domain
IPR020422  Dual specificity phosphatase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9205128
11717427
11733513
12138158
12477932
14574404
14702039
15138252
15252450
15489334
16344560
16636663
17068812
17384676
20018849
21030553
21139048
21988832
22796920
23000965
23337887
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0008283  cell proliferation
GO:0000188  inactivation of MAPK activity
GO:0007275  multicellular organismal development
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0046330  positive regulation of JNK cascade
GO:0006470  protein amino acid dephosphorylation
GO:0042127  regulation of cell proliferation
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0004725  protein tyrosine phosphatase activity
GO:0008138  protein tyrosine/serine/threonine phosphatase activity