proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

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Synonym

p28, dJ889N15.2, PSMD10, Gankyrin, 26S proteasome regulatory subunit p28, 26S proteasome non-ATPase regulatory subunit 10

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:116.10 cerebellum:63 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:23.50 artery/aorta:30 vein:133.30 lymphnode:121.30 peripheral blood:- spleen:- thymus:38.70 bone marrow:- adipose:40.30 bone:25.60 skin:86.40
GeneChip cerebrum:7.83 cerebellum:7.63 brain stem:8.28 corpus callosum/glia:8.10 pineal gland:- peripheral nerve:7.82 spine:8.17 retina:- eye:- artery/aorta:6.92 vein:6.79 lymphnode:7.04 peripheral blood:- spleen:7.22 thymus:7.78 bone marrow:6.96 adipose:7.37 bone:- skin:7.34
CAGE cerebrum:3.50 cerebellum:- brain stem:3.88 corpus callosum/glia:3.74 pineal gland:3.50 peripheral nerve:- spine:3.57 retina:- eye:- artery/aorta:2.74 vein:2.66 lymphnode:2.85 peripheral blood:- spleen:2.94 thymus:3.19 bone marrow:- adipose:3.02 bone:- skin:-
RNA-seq cerebrum:5.19 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.20 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.20 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:116.60 prostate:- ovary:111.80 testis:112.50 heart:114.90 muscle:40.20 esophagus:- stomach:21.20 intestine:- colon:17     liver/hepato:52.80        lung:53.80    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:53.30 breast:46.50 salivary:-
GeneChip uterus:7.93 placenta:7.43 prostate:8.11 ovary:8.07 testis:7.66 heart:6.69 muscle:6.85 esophagus:7.54 stomach:7.24 intestine:7.10 colon:6.84 liver/hepato:6.51 lung:7.07 bladder:- kidney:7.08 pituitary:7.89 thyroid/parathyroid:7.62 adrenal gland:7.43 pancreas:7.12 breast:7.41 salivary:7.24
CAGE uterus:3.27 placenta:3.49 prostate:3.22 ovary:3.20 testis:3.07 heart:2.62 muscle:2.27 esophagus:3.37 stomach:- intestine:3.17 colon:2.55     liver/hepato:2.84    lung:3.00 bladder:3.42 kidney:3.29 pituitary:3.48 thyroid/parathyroid:3.44 adrenal gland:- pancreas:2.48 breast:2.69 salivary:2.90
RNA-seq uterus:- placenta:- prostate:4.59 ovary:4.93 testis:5.14 heart:3.04 muscle:2.66 esophagus:- stomach:- intestine:- colon:4.66     liver/hepato:3.71        lung:4.80    bladder:- kidney:4.11 pituitary:- thyroid/parathyroid:4.53 adrenal gland:4.29 pancreas:- breast:4.49 salivary:-

Gene Information

IDs

Refseq ID NM_002814
Gene ID 5716
Unigene ID Hs.522752
Probe set ID 219485_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000101843
GTEx ID ENSG00000101843

Orthologous Gene

Mouse[2]  NM_001164177, NM_016883
Rat[2]  NM_001164177, NM_016883

Chromosomal Region

Xq22.3  [107,327,437  -  107,334,848]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8811196
9009162
9079628
9714768
9811770
9846577
10613832
10893419
11285280
11779854
11900540
12167863
12174370
12419264
12477932
12525503
12719574
12750511
12791267
12808465
12808466
12809610
12830140
12840737
12859895
12914693
12920286
12970355
14527406
14528300
14528301
14550573
14557625
14564014
14573599
14614829
14997555
15029244
15221469
15379554
15489334
15772651
15910504
16023600
16196087
16239144
17323924
17353931
17881001
17904523
17935131
18029348
18040287
18161051
18332869
18813787
19235584
19287195
19349277
19412159
19490896
19513507
19615732
19729910
19736567
19901563
20371329
20479760
20483533
20628200
21139048
21254169
21287809
21691299
21868508
21890473
21906983
21988832
22053931
22118674
22230478
22387393
22797925
22863883
22890318
22913272
22913315
22939629
23000965
23100276
23276718
23317503
23503661
23508981
23576566
23751493
24037855

Gene Ontology  (GO ID)

Biological Process

GO:0031145  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0006915  apoptosis
GO:0034641  cellular nitrogen compound metabolic process
GO:0007253  cytoplasmic sequestering of NF-kappaB
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000082  G1/S transition of mitotic cell cycle
GO:0010467  gene expression
GO:0000278  mitotic cell cycle
GO:0016071  mRNA metabolic process
GO:0043066  negative regulation of apoptosis
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043409  negative regulation of MAPKKK cascade
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0051436  negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0030307  positive regulation of cell growth
GO:0045737  positive regulation of cyclin-dependent protein kinase activity
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398  positive regulation of protein ubiquitination
GO:0051437  positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0070682  proteasome regulatory particle assembly
GO:0000209  protein polyubiquitination
GO:0042981  regulation of apoptosis
GO:0006521  regulation of cellular amino acid metabolic process
GO:0051439  regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0016070  RNA metabolic process
GO:0016032  viral reproduction

Cellular Component

GO:0015629  actin cytoskeleton
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0045111  intermediate filament cytoskeleton
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0000502  proteasome complex
GO:0005838  proteasome regulatory particle
GO:0008540  proteasome regulatory particle, base subcomplex

Molecular Function

GO:0005515  protein binding
GO:0008134  transcription factor binding