prostaglandin E receptor 4 (subtype EP4)

Synonym

PTGER4, Prostaglandin E2 receptor, EP4 subtype, prostaglandin E receptor 4 (subtype EP4), EP4R, EP4, PTGER2, PGE receptor, EP4 subtype, MGC126583, Prostanoid EP4 receptor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:4.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:17.60

artery/aorta:-

vein:-

lymphnode:242.60

peripheral blood:54.70

spleen:-

thymus:77.30

bone marrow:39.40

adipose:121

bone:12.80

skin:52.80

GeneChip

cerebrum:3.23

cerebellum:2.96

brain stem:3.56

corpus callosum/glia:3.54

pineal gland:-

peripheral nerve:6.18

spine:4.66

retina:-

eye:-

artery/aorta:5.27

vein:6.92

lymphnode:6.84

peripheral blood:-

spleen:7.22

thymus:6.93

bone marrow:5.34

adipose:6.30

bone:-

skin:6.07

CAGE

cerebrum:0.86

cerebellum:-

brain stem:1.59

corpus callosum/glia:1.53

pineal gland:1.13

peripheral nerve:-

spine:1.85

retina:-

eye:-

artery/aorta:2.85

vein:3.01

lymphnode:3.28

peripheral blood:-

spleen:3.56

thymus:3.61

bone marrow:-

adipose:3.07

bone:-

skin:-

RNA-seq

cerebrum:0.55

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.28

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.96

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:3.60

prostate:22.50

ovary:-

testis:13

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:17

liver/hepato:10.60

lung:68.40

bladder:-

kidney:41.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:53.30

breast:-

salivary:-

GeneChip

uterus:5.12

placenta:3.53

prostate:5.32

ovary:5.44

testis:4.85

heart:5.54

muscle:4.73

esophagus:4.77

stomach:6.48

intestine:7.17

colon:6.65

liver/hepato:3.97

lung:7.70

bladder:-

kidney:5.95

pituitary:3.48

thyroid/parathyroid:4.68

adrenal gland:6.38

pancreas:6.88

breast:6.46

salivary:3.64

CAGE

uterus:2.59

placenta:1.64

prostate:2.68

ovary:2.23

testis:1.10

heart:2.58

muscle:2.26

esophagus:2.49

stomach:-

intestine:3.95

colon:3.55

liver/hepato:1.97

lung:3.49

bladder:3.11

kidney:2.75

pituitary:0.95

thyroid/parathyroid:1.80

adrenal gland:-

pancreas:4.58

breast:2.59

salivary:1.67

RNA-seq

uterus:-

placenta:-

prostate:2.33

ovary:1.17

testis:1.64

heart:1.63

muscle:1.09

esophagus:-

stomach:-

intestine:-

colon:3.11

liver/hepato:0.56

lung:3.65

bladder:-

kidney:3.20

pituitary:-

thyroid/parathyroid:1.60

adrenal gland:3.36

pancreas:-

breast:3.30

salivary:-

IDs

Refseq ID	NM_000958
Gene ID	5734
Unigene ID	Hs.199248
Probe set ID	204897_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000171522
GTEx ID	ENSG00000171522

Orthologous Gene

Mouse[4]	NM_001136079, NM_008965
Rat [0]

Chromosomal Region

5p13.1 [40,679,600 - 40,693,837]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000276	7TM GPCR, rhodopsin-like
IPR017452	GPCR, rhodopsin-like superfamily
IPR001244	Prostaglandin DP receptor
IPR001758	Prostanoid EP4 receptor
IPR008365	Prostanoid receptor

Gene Ontology (GO ID)

Biological Process

GO:0060348	bone development
GO:0071260	cellular response to mechanical stimulus
GO:0070371	ERK1 and ERK2 cascade
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0006955	immune response
GO:0007254	JNK cascade
GO:0050710	negative regulation of cytokine secretion
GO:0050728	negative regulation of inflammatory response
GO:0033624	negative regulation of integrin activation
GO:0050715	positive regulation of cytokine secretion
GO:0050729	positive regulation of inflammatory response
GO:0030278	regulation of ossification
GO:0051492	regulation of stress fiber formation
GO:0032496	response to lipopolysaccharide
GO:0009612	response to mechanical stimulus
GO:0042093	T-helper cell differentiation

Cellular Component

GO:0016021	integral to membrane
GO:0005886	plasma membrane

Molecular Function

GO:0004957	prostaglandin E receptor activity
GO:0005515	protein binding

prostaglandin E receptor 4 (subtype EP4)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function