BCL2-associated X protein

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:-
GeneChip nodata
CAGE cerebrum:2.51 cerebellum:- brain stem:2.68 corpus callosum/glia:2.81 pineal gland:1.94 peripheral nerve:- spine:2.65 retina:- eye:- artery/aorta:3.24 vein:3.37 lymphnode:3.27 peripheral blood:- spleen:3.66 thymus:3.51 bone marrow:- adipose:2.72 bone:- skin:-
RNA-seq cerebrum:0.16 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.21 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:- ovary:37.30 testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:2.63 placenta:3.06 prostate:2.92 ovary:2.89 testis:2.53 heart:2.84 muscle:2.13 esophagus:2.88 stomach:- intestine:3.39 colon:3.47     liver/hepato:3.18    lung:3.49 bladder:2.80 kidney:2.99 pituitary:2.39 thyroid/parathyroid:2.89 adrenal gland:- pancreas:2.76 breast:3.16 salivary:2.26
RNA-seq uterus:- placenta:- prostate:0 ovary:0.14 testis:0.00 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0.03        lung:0    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.17 adrenal gland:0.62 pancreas:- breast:0.37 salivary:-

Gene Information

IDs

Refseq ID NR_027882
Gene ID 581
Unigene ID Hs.624291
Probe set ID -
Ensembl ID -
GTEx ID -

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

19q13.33  [49,458,072  -  49,465,055]

Gene Family (Interpro ID)

IPR000712  Apoptosis regulator, Bcl-2, BH
IPR002475  BCL2-like apoptosis inhibitor

Link to Pubmed  (Pubmed ID)

7566098
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Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0008635  activation of caspase activity by cytochrome c
GO:0006915  apoptosis
GO:0070059  apoptosis in response to endoplasmic reticulum stress
GO:0008637  apoptotic mitochondrial changes
GO:0001783  B cell apoptosis
GO:0001782  B cell homeostasis
GO:0002358  B cell homeostatic proliferation
GO:0002352  B cell negative selection
GO:0001974  blood vessel remodeling
GO:0071310  cellular response to organic substance
GO:0034644  cellular response to UV
GO:0021987  cerebral cortex development
GO:0006922  cleavage of lamin
GO:0045136  development of secondary sexual characteristics
GO:0006309  DNA fragmentation involved in apoptosis
GO:0010248  establishment or maintenance of transmembrane electrochemical gradient
GO:0009566  fertilization
GO:0007281  germ cell development
GO:0035234  germ cell programmed cell death
GO:0006687  glycosphingolipid metabolic process
GO:0048873  homeostasis of number of cells within a tissue
GO:0021854  hypothalamus development
GO:0006917  induction of apoptosis
GO:0001822  kidney development
GO:0035108  limb morphogenesis
GO:0043653  mitochondrial fragmentation during apoptosis
GO:0008053  mitochondrial fusion
GO:0002262  myeloid cell homeostasis
GO:0048147  negative regulation of fibroblast proliferation
GO:0043524  negative regulation of neuron apoptosis
GO:0033137  negative regulation of peptidyl-serine phosphorylation
GO:0032091  negative regulation of protein binding
GO:0051402  neuron apoptosis
GO:0001764  neuron migration
GO:0030264  nuclear fragmentation during apoptosis
GO:0042475  odontogenesis of dentine-containing tooth
GO:0001541  ovarian follicle development
GO:0043065  positive regulation of apoptosis
GO:0060058  positive regulation of apoptosis involved in mammary gland involution
GO:0002904  positive regulation of B cell apoptosis
GO:0043525  positive regulation of neuron apoptosis
GO:0048087  positive regulation of pigmentation during development
GO:0032461  positive regulation of protein oligomerization
GO:0090200  positive regulation of release of cytochrome c from mitochondria
GO:0051281  positive regulation of release of sequestered calcium ion into cytosol
GO:0048597  post-embryonic camera-type eye morphogenesis
GO:0051260  protein homooligomerization
GO:0001844  protein insertion into mitochondrial membrane during induction of apoptosis
GO:0051259  protein oligomerization
GO:0032471  reduction of endoplasmic reticulum calcium ion concentration
GO:0051726  regulation of cell cycle
GO:0033599  regulation of mammary gland epithelial cell proliferation
GO:0051881  regulation of mitochondrial membrane potential
GO:0006808  regulation of nitrogen utilization
GO:0043497  regulation of protein heterodimerization activity
GO:0043496  regulation of protein homodimerization activity
GO:0001836  release of cytochrome c from mitochondria
GO:0032976  release of matrix enzymes from mitochondria
GO:0001101  response to acid
GO:0048678  response to axon injury
GO:0006974  response to DNA damage stimulus
GO:0010332  response to gamma radiation
GO:0009651  response to salt stress
GO:0009636  response to toxin
GO:0060041  retina development in camera-type eye
GO:0046666  retinal cell programmed cell death
GO:0060011  Sertoli cell proliferation
GO:0048515  spermatid differentiation
GO:0001777  T cell homeostatic proliferation
GO:0006927  transformed cell apoptosis
GO:0060068  vagina development
GO:0019048  virus-host interaction

Cellular Component

GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0005741  mitochondrial outer membrane
GO:0005757  mitochondrial permeability transition pore complex
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0046930  pore complex

Molecular Function

GO:0051434  BH3 domain binding
GO:0015267  channel activity
GO:0042802  identical protein binding
GO:0008289  lipid binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity