poliovirus receptor-related 2 (herpesvirus entry mediator B)

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Synonym

Nectin-2, CD112 antigen, PVRR2, HVEB, HveB, PRR2, PVRL2, Herpes virus entry mediator B, CD112, Poliovirus receptor-related protein 2 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.51 cerebellum:6.42 brain stem:6.55 corpus callosum/glia:6.41 pineal gland:- peripheral nerve:6.99 spine:6.32 retina:- eye:- artery/aorta:7.32 vein:7.51 lymphnode:6.92 peripheral blood:- spleen:7.02 thymus:6.09 bone marrow:6.25 adipose:7.09 bone:- skin:7.23
CAGE cerebrum:2.57 cerebellum:- brain stem:2.66 corpus callosum/glia:2.85 pineal gland:3.94 peripheral nerve:- spine:2.84 retina:- eye:- artery/aorta:3.81 vein:3.36 lymphnode:3.72 peripheral blood:- spleen:4.01 thymus:1.85 bone marrow:- adipose:3.97 bone:- skin:-
RNA-seq cerebrum:2.29 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.21 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.86 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.16 placenta:7.15 prostate:7.28 ovary:6.97 testis:7.08 heart:7.16 muscle:6.91 esophagus:7.17 stomach:7.12 intestine:6.92 colon:7.02 liver/hepato:7.05 lung:7.52 bladder:- kidney:7.04 pituitary:6.74 thyroid/parathyroid:7.21 adrenal gland:7.41 pancreas:7.05 breast:7.29 salivary:6.81
CAGE uterus:3.81 placenta:4.31 prostate:3.88 ovary:3.81 testis:4.43 heart:3.75 muscle:3.07 esophagus:4.08 stomach:- intestine:4.29 colon:3.79     liver/hepato:4.38    lung:4.32 bladder:3.67 kidney:3.83 pituitary:3.07 thyroid/parathyroid:3.98 adrenal gland:- pancreas:3.34 breast:4.26 salivary:3.83
RNA-seq uterus:- placenta:- prostate:3.17 ovary:3.53 testis:3.75 heart:2.71 muscle:2.35 esophagus:- stomach:- intestine:- colon:3.89     liver/hepato:3.42        lung:5.20    bladder:- kidney:3.25 pituitary:- thyroid/parathyroid:4.28 adrenal gland:4.44 pancreas:- breast:3.91 salivary:-

Gene Information

IDs

Refseq ID NM_002856
Gene ID 5819
Unigene ID -
Probe set ID 203149_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000130202
GTEx ID ENSG00000130202

Orthologous Gene

Mouse[2]  NM_001159724, NM_008990
Rat [0]  

Chromosomal Region

19q13.32  [45,349,393  -  45,392,485]

Gene Family (Interpro ID)

IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup

Link to Pubmed  (Pubmed ID)

7622062
9657005
9683266
9845526
10196354
10225955
10520737
10617658
10627537
10729168
10733589
11544254
11602758
11984219
12011057
12438620
12477932
12913096
12915581
15039383
15146197
15465608
15489334
15536144
15607800
15811349
16169070
16189514
16304049
16313259
16344560
16738668
16740910
16831868
17081983
17376543
17534374
17696193
18823527
19011627
19478445
19815499
19913121
20410314
20572854
20617580
20628086
20634891
20662561
20672350
20885792
21139048
21383766
21900206
21906983
21909109
21982860
21988832
22005931
22159054
22927415
23192594
23326517
23419831
23465821
23565137
24116228

Gene Ontology  (GO ID)

Biological Process

GO:0001675  acrosome assembly
GO:0034332  adherens junction organization
GO:0051856  adhesion to symbiont
GO:0034329  cell junction assembly
GO:0032990  cell part morphogenesis
GO:0045216  cell-cell junction organization
GO:0007010  cytoskeleton organization
GO:0051654  establishment of mitochondrion localization
GO:0009566  fertilization
GO:0007156  homophilic cell adhesion
GO:0002891  positive regulation of immunoglobulin mediated immune response
GO:0033005  positive regulation of mast cell activation
GO:0045954  positive regulation of natural killer cell mediated cytotoxicity
GO:0002860  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0050776  regulation of immune response
GO:0030382  sperm mitochondrion organization
GO:0007286  spermatid development
GO:0007289  spermatid nucleus differentiation
GO:0042271  susceptibility to natural killer cell mediated cytotoxicity
GO:0060370  susceptibility to T cell mediated cytotoxicity
GO:0019064  viral envelope fusion with host membrane
GO:0046814  virion attachment, binding of host cell surface coreceptor
GO:0019048  virus-host interaction

Cellular Component

GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0016021  integral to membrane
GO:0005886  plasma membrane
GO:0005915  zonula adherens

Molecular Function

GO:0050839  cell adhesion molecule binding
GO:0015026  coreceptor activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity