transient receptor potential cation channel, subfamily V, member 4

Synonym

VROAC, TRP12, Transient receptor potential protein 12, TRPV4, VRL2, osm-9-like TRP channel 4, VR-OAC, Vanilloid receptor-like channel 2, OTRPC4, Vanilloid receptor-like protein 2, VRL-2, TrpV4

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:237.30

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:12.80

skin:28.80

GeneChip

cerebrum:4.86

cerebellum:5.13

brain stem:4.89

corpus callosum/glia:5.05

pineal gland:-

peripheral nerve:4.61

spine:4.71

retina:-

eye:-

artery/aorta:4.91

vein:5.55

lymphnode:4.92

peripheral blood:-

spleen:4.59

thymus:4.64

bone marrow:4.95

adipose:4.95

bone:-

skin:5.43

CAGE

cerebrum:0.27

cerebellum:-

brain stem:0.24

corpus callosum/glia:1.31

pineal gland:1.18

peripheral nerve:-

spine:0.17

retina:-

eye:-

artery/aorta:1.94

vein:0.79

lymphnode:1.62

peripheral blood:-

spleen:1.36

thymus:0.12

bone marrow:-

adipose:0.78

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.17

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:18.20

prostate:22.50

ovary:-

testis:4.30

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:-

lung:4.90

bladder:-

kidney:83.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:18.60

salivary:-

GeneChip

uterus:4.90

placenta:5.25

prostate:4.82

ovary:5.06

testis:4.58

heart:4.98

muscle:5.02

esophagus:5.18

stomach:4.77

intestine:5.10

colon:4.74

liver/hepato:5.12

lung:5.21

bladder:-

kidney:5.53

pituitary:4.68

thyroid/parathyroid:4.59

adrenal gland:4.61

pancreas:5.04

breast:4.94

salivary:5.82

CAGE

uterus:0.78

placenta:2.33

prostate:1.87

ovary:0.47

testis:0.45

heart:0.72

muscle:0.17

esophagus:1.60

stomach:-

intestine:0.14

colon:0.50

liver/hepato:1.79

lung:1.37

bladder:1.02

kidney:2.16

pituitary:1.29

thyroid/parathyroid:0.53

adrenal gland:-

pancreas:2.08

breast:1.16

salivary:3.54

RNA-seq

uterus:-

placenta:-

prostate:0

ovary:0.06

testis:0.00

heart:0

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.09

lung:0.24

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:0.21

pancreas:-

breast:0.16

salivary:-

IDs

Refseq ID	NM_147204
Gene ID	59341
Unigene ID	Hs.506713
Probe set ID	219516_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000111199
GTEx ID	ENSG00000111199

Orthologous Gene

Mouse[1]	NM_022017
Rat[1]	NM_023970

Chromosomal Region

12q24.11 [110,220,890 - 110,271,212]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR004729	Transient receptor potential channel
IPR008347	Vanilloid receptor
IPR008348	Vanilloid receptor 2

Gene Ontology (GO ID)

Biological Process

GO:0031532	actin cytoskeleton reorganization
GO:0007015	actin filament organization
GO:0070509	calcium ion import
GO:0006816	calcium ion transport
GO:0008219	cell death
GO:0006884	cell volume homeostasis
GO:0007043	cell-cell junction assembly
GO:0006874	cellular calcium ion homeostasis
GO:0071476	cellular hypotonic response
GO:0034605	cellular response to heat
GO:0071470	cellular response to osmotic stress
GO:0043622	cortical microtubule organization
GO:0007204	elevation of cytosolic calcium ion concentration
GO:0042538	hyperosmotic salinity response
GO:0046785	microtubule polymerization
GO:0010977	negative regulation of neuron projection development
GO:0007231	osmosensory signaling pathway
GO:0031117	positive regulation of microtubule depolymerization
GO:0047484	regulation of response to osmotic stress
GO:0009612	response to mechanical stimulus
GO:0030103	vasopressin secretion

Cellular Component

GO:0005912	adherens junction
GO:0005929	cilium
GO:0030864	cortical actin cytoskeleton
GO:0005881	cytoplasmic microtubule
GO:0030175	filopodium
GO:0005925	focal adhesion
GO:0030426	growth cone
GO:0016021	integral to membrane
GO:0030027	lamellipodium
GO:0005886	plasma membrane
GO:0032587	ruffle membrane

Molecular Function

GO:0003779	actin binding
GO:0051015	actin filament binding
GO:0043014	alpha-tubulin binding
GO:0005524	ATP binding
GO:0048487	beta-tubulin binding
GO:0005262	calcium channel activity
GO:0005516	calmodulin binding
GO:0005261	cation channel activity
GO:0008017	microtubule binding
GO:0005034	osmosensor activity
GO:0019901	protein kinase binding
GO:0005080	protein kinase C binding
GO:0042169	SH2 domain binding

transient receptor potential cation channel, subfamily V, member 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function