ribosomal protein S6 kinase, 90kDa, polypeptide 2

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Synonym

ribosomal protein S6 kinase, 90kDa, polypeptide 2, Ribosomal protein S6 kinase alpha-2, RSK3, S6K-alpha, MAP kinase-activated protein kinase 1c, Ribosomal S6 kinase 3, S6K-alpha2, pp90RSK3, HU-2, RSK-3, 90 kDa ribosomal protein S6 kinase 2, MAPKAPK1C, p90-RSK3, p90-RSK 2, RPS6KA2, S6K-alpha 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.80 cerebellum:6.68 brain stem:7.99 corpus callosum/glia:8.29 pineal gland:- peripheral nerve:7.51 spine:8.53 retina:- eye:- artery/aorta:6.77 vein:5.89 lymphnode:5.69 peripheral blood:- spleen:7.60 thymus:4.46 bone marrow:5.14 adipose:6.67 bone:- skin:6.51
CAGE cerebrum:3.65 cerebellum:- brain stem:3.74 corpus callosum/glia:3.81 pineal gland:2.44 peripheral nerve:- spine:3.87 retina:- eye:- artery/aorta:3.10 vein:2.20 lymphnode:2.51 peripheral blood:- spleen:2.67 thymus:1.03 bone marrow:- adipose:3.04 bone:- skin:-
RNA-seq cerebrum:3.82 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.67 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.06 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.79 placenta:5.72 prostate:7.06 ovary:6.90 testis:4.79 heart:7.19 muscle:6.56 esophagus:5.75 stomach:6.70 intestine:6.13 colon:5.71 liver/hepato:5.05 lung:8.19 bladder:- kidney:6.50 pituitary:7.83 thyroid/parathyroid:7.70 adrenal gland:6.14 pancreas:6.17 breast:6.50 salivary:6.10
CAGE uterus:2.75 placenta:1.91 prostate:2.76 ovary:2.66 testis:1.85 heart:3.26 muscle:1.86 esophagus:2.29 stomach:- intestine:1.92 colon:2.63     liver/hepato:1.71    lung:3.77 bladder:3.09 kidney:2.40 pituitary:3.66 thyroid/parathyroid:2.96 adrenal gland:- pancreas:4.09 breast:3.38 salivary:2.22
RNA-seq uterus:- placenta:- prostate:2.57 ovary:3.24 testis:2.33 heart:1.22 muscle:1.87 esophagus:- stomach:- intestine:- colon:3.52     liver/hepato:1.23        lung:0.91    bladder:- kidney:2.31 pituitary:- thyroid/parathyroid:3.46 adrenal gland:3.67 pancreas:- breast:2.94 salivary:-

Gene Information

IDs

Refseq ID NM_001006932
Gene ID 6196
Unigene ID -
Probe set ID 212912_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000071242
GTEx ID ENSG00000071242

Orthologous Gene

Mouse[2]  NM_011299
Rat [0]  

Chromosomal Region

6q27  [166,822,852  -  167,319,939]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1602151
7623830
8141249
8663493
8688081
8756728
8939914
9155018
9381178
9687510
9770464
9829964
9915826
10480933
10501965
10521512
10837486
10880354
10949026
11160957
11175347
11495723
11698596
12016217
12393804
12477932
12832467
12897128
14574404
14646589
14702039
15112576
15276183
15345747
15489334
15995633
16217014
16621805
16626623
16810323
16878154
16895915
17192257
17370265
20379614
21035469
21527514
21988832
22939624
22939629
23128233
23259602
23455922
23602568
23635776
23727904
24722188

Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0002035  brain renin-angiotensin system
GO:0010659  cardiac muscle cell apoptosis
GO:0071322  cellular response to carbohydrate stimulus
GO:0060047  heart contraction
GO:0007507  heart development
GO:0045087  innate immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0045786  negative regulation of cell cycle
GO:0008285  negative regulation of cell proliferation
GO:0045835  negative regulation of meiosis
GO:0048011  nerve growth factor receptor signaling pathway
GO:0001556  oocyte maturation
GO:0018105  peptidyl-serine phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0010628  positive regulation of gene expression
GO:0007243  protein kinase cascade
GO:0070613  regulation of protein processing
GO:0007165  signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0007268  synaptic transmission
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005819  spindle

Molecular Function

GO:0005524  ATP binding
GO:0000287  magnesium ion binding
GO:0004674  protein serine/threonine kinase activity
GO:0004711  ribosomal protein S6 kinase activity