mitogen-activated protein kinase 12

Synonym

ERK6, Stress-activated protein kinase 3, MAPK12, MAP kinase p38 gamma, ERK5, Mitogen-activated protein kinase p38 gamma, ERK-6, Mitogen-activated protein kinase 12, mitogen-activated protein kinase 12, SAPK-3, PRKM12, SAPK3, P38GAMMA, p38gamma, Extracellular signal-regulated kinase 6

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:47.40

cerebellum:-

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:-

spine:112.30

retina:-

eye:17.60

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:18.90

thymus:-

bone marrow:-

adipose:40.30

bone:-

skin:4.80

GeneChip

cerebrum:5.35

cerebellum:5.72

brain stem:5.38

corpus callosum/glia:5.09

pineal gland:-

peripheral nerve:5.09

spine:4.92

retina:-

eye:-

artery/aorta:4.97

vein:5.09

lymphnode:4.99

peripheral blood:-

spleen:4.64

thymus:4.29

bone marrow:4.79

adipose:5.15

bone:-

skin:5.11

CAGE

cerebrum:2.11

cerebellum:-

brain stem:1.87

corpus callosum/glia:1.60

pineal gland:1.30

peripheral nerve:-

spine:1.99

retina:-

eye:-

artery/aorta:1.38

vein:0.79

lymphnode:1.21

peripheral blood:-

spleen:0.66

thymus:0.18

bone marrow:-

adipose:1.33

bone:-

skin:-

RNA-seq

cerebrum:1.92

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.07

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.28

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:14.60

prostate:22.50

ovary:-

testis:4.30

heart:-

muscle:261.20

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:4.90

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.16

placenta:4.52

prostate:4.56

ovary:5.05

testis:4.62

heart:5.33

muscle:8.49

esophagus:5.44

stomach:4.96

intestine:5.52

colon:5.15

liver/hepato:4.95

lung:5.03

bladder:-

kidney:5.27

pituitary:5.89

thyroid/parathyroid:4.29

adrenal gland:4.82

pancreas:5.47

breast:4.58

salivary:4.78

CAGE

uterus:1.75

placenta:0.81

prostate:1.36

ovary:1.64

testis:1.05

heart:1.77

muscle:4.00

esophagus:1.39

stomach:-

intestine:0.48

colon:1.16

liver/hepato:0.63

lung:1.50

bladder:1.30

kidney:1.42

pituitary:1.96

thyroid/parathyroid:1.19

adrenal gland:-

pancreas:0.94

breast:1.68

salivary:0.36

RNA-seq

uterus:-

placenta:-

prostate:1.93

ovary:2.85

testis:2.15

heart:1.60

muscle:5.98

esophagus:-

stomach:-

intestine:-

colon:1.41

liver/hepato:0.42

lung:1.76

bladder:-

kidney:1.84

pituitary:-

thyroid/parathyroid:3.33

adrenal gland:2.77

pancreas:-

breast:2.00

salivary:-

IDs

Refseq ID	NM_002969
Gene ID	6300
Unigene ID	Hs.432642
Probe set ID	206106_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000188130
GTEx ID	ENSG00000188130

Orthologous Gene

Mouse[1]	NM_013871
Rat [0]

Chromosomal Region

22q13.33 [50,683,879 - 50,700,254]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR008352	MAP kinase, p38
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0007050	cell cycle arrest
GO:0006975	DNA damage induced protein phosphorylation
GO:0042692	muscle cell differentiation
GO:0007517	muscle organ development
GO:0045445	myoblast differentiation
GO:0048011	nerve growth factor receptor signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0051149	positive regulation of muscle cell differentiation
GO:0007265	Ras protein signal transduction
GO:0006355	regulation of transcription, DNA-dependent
GO:0007165	signal transduction
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0005829	cytosol
GO:0005739	mitochondrion
GO:0005654	nucleoplasm

Molecular Function

GO:0005524	ATP binding
GO:0000287	magnesium ion binding
GO:0004707	MAP kinase activity
GO:0005515	protein binding
GO:0004674	protein serine/threonine kinase activity

mitogen-activated protein kinase 12

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function