chemokine (C-C motif) ligand 3

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Synonym

PAT 464.1, G0S19-1, chemokine (C-C motif) ligand 3, Tonsillar lymphocyte LD78 alpha protein, SCYA3, G0S19-1 protein, SIS-beta, G0/G1 switch regulatory protein 19-1, LD78ALPHA, MIP-1-alpha, MIP1A, CCL3, Small inducible cytokine A3 precursor, Macrophage inflammatory protein 1-alpha

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:- spine:- retina:- eye:41.10 artery/aorta:- vein:- lymphnode:182 peripheral blood:419 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:4.76 cerebellum:4.55 brain stem:4.96 corpus callosum/glia:6.51 pineal gland:- peripheral nerve:5.49 spine:8.47 retina:- eye:- artery/aorta:5.87 vein:5.41 lymphnode:6.45 peripheral blood:- spleen:9.13 thymus:4.77 bone marrow:6.36 adipose:6.29 bone:- skin:4.87
CAGE cerebrum:0.67 cerebellum:- brain stem:1.22 corpus callosum/glia:2.85 pineal gland:0 peripheral nerve:- spine:0.42 retina:- eye:- artery/aorta:2.53 vein:1.92 lymphnode:1.78 peripheral blood:- spleen:3.14 thymus:1.26 bone marrow:- adipose:2.05 bone:- skin:-
RNA-seq cerebrum:2.87 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.26 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.35 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:40.10 prostate:33.80 ovary:37.30 testis:- heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:34.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:- salivary:-
GeneChip uterus:5.02 placenta:6.84 prostate:5.38 ovary:5.21 testis:4.49 heart:4.66 muscle:4.46 esophagus:4.50 stomach:5.04 intestine:4.88 colon:4.97 liver/hepato:6.71 lung:6.85 bladder:- kidney:4.72 pituitary:4.63 thyroid/parathyroid:4.80 adrenal gland:5.16 pancreas:4.35 breast:5.17 salivary:4.79
CAGE uterus:1.04 placenta:2.13 prostate:0.74 ovary:1.37 testis:1.44 heart:1.25 muscle:0.61 esophagus:0.86 stomach:- intestine:0.93 colon:0.90     liver/hepato:2.25    lung:3.00 bladder:1.52 kidney:0.33 pituitary:0.26 thyroid/parathyroid:0.41 adrenal gland:- pancreas:0.58 breast:1.53 salivary:0.62
RNA-seq uterus:- placenta:- prostate:1.09 ovary:1.85 testis:1.28 heart:0.17 muscle:0.26 esophagus:- stomach:- intestine:- colon:0.09     liver/hepato:1.09        lung:5.17    bladder:- kidney:0.47 pituitary:- thyroid/parathyroid:0.34 adrenal gland:3.49 pancreas:- breast:2.70 salivary:-

Gene Information

IDs

Refseq ID NM_002983
Gene ID 6348
Unigene ID Hs.514107
Probe set ID 205114_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000006075
GTEx ID ENSG00000006075

Orthologous Gene

Mouse[1]  NM_011337
Rat [0]  

Chromosomal Region

17q12  [34,415,602  -  34,417,515]

Gene Family (Interpro ID)

IPR001811  Small chemokine, interleukin-8-like

Link to Pubmed  (Pubmed ID)

1004873
1296815
1694014
1972563
2271120
2521882
3058856
3086300
3279154
7537510
7545673
7594543
7695626
8077676
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24413563

Gene Ontology  (GO ID)

Biological Process

GO:0043615  astrocyte cell migration
GO:0007610  behavior
GO:0006816  calcium ion transport
GO:0019722  calcium-mediated signaling
GO:0001775  cell activation
GO:0007267  cell-cell signaling
GO:0006874  cellular calcium ion homeostasis
GO:0071346  cellular response to interferon-gamma
GO:0071347  cellular response to interleukin-1
GO:0071407  cellular response to organic cyclic substance
GO:0071356  cellular response to tumor necrosis factor
GO:0006935  chemotaxis
GO:0007010  cytoskeleton organization
GO:0048245  eosinophil chemotaxis
GO:0043308  eosinophil degranulation
GO:0006887  exocytosis
GO:0006954  inflammatory response
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0048247  lymphocyte chemotaxis
GO:0048246  macrophage chemotaxis
GO:0000165  MAPKKK cascade
GO:0002548  monocyte chemotaxis
GO:0043922  negative regulation by host of viral transcription
GO:0030502  negative regulation of bone mineralization
GO:0010629  negative regulation of gene expression
GO:0045671  negative regulation of osteoclast differentiation
GO:0030593  neutrophil chemotaxis
GO:0001649  osteoblast differentiation
GO:0016310  phosphorylation
GO:0050918  positive chemotaxis
GO:0051928  positive regulation of calcium ion transport
GO:0050850  positive regulation of calcium-mediated signaling
GO:0030335  positive regulation of cell migration
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010628  positive regulation of gene expression
GO:0050729  positive regulation of inflammatory response
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0043525  positive regulation of neuron apoptosis
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0032760  positive regulation of tumor necrosis factor production
GO:0006468  protein amino acid phosphorylation
GO:0043491  protein kinase B signaling cascade
GO:0008360  regulation of cell shape
GO:0051930  regulation of sensory perception of pain
GO:0014808  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0070723  response to cholesterol
GO:0009636  response to toxin
GO:0010818  T cell chemotaxis

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005622  intracellular

Molecular Function

GO:0004698  calcium-dependent protein kinase C activity
GO:0031726  CCR1 chemokine receptor binding
GO:0031730  CCR5 chemokine receptor binding
GO:0042056  chemoattractant activity
GO:0008009  chemokine activity
GO:0016301  kinase activity
GO:0016004  phospholipase activator activity
GO:0005515  protein binding
GO:0004672  protein kinase activity