PR domain containing 16

 jump to detail

Synonym

Transcription factor MEL1, KIAA1675, PR domain zinc finger protein 16, PR domain containing 16, PFM13, PR domain-containing protein 16, PRDM16, MEL1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:14.20 cerebellum:- brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:122.70 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:25.80 bone marrow:- adipose:40.30 bone:- skin:24
GeneChip cerebrum:4.20 cerebellum:4.37 brain stem:4.31 corpus callosum/glia:4.12 pineal gland:- peripheral nerve:4.29 spine:4.13 retina:- eye:- artery/aorta:4.64 vein:4.37 lymphnode:4.27 peripheral blood:- spleen:3.99 thymus:3.96 bone marrow:4.38 adipose:4.43 bone:- skin:4.58
CAGE cerebrum:1.57 cerebellum:- brain stem:1.41 corpus callosum/glia:1.84 pineal gland:0.56 peripheral nerve:- spine:1.48 retina:- eye:- artery/aorta:3.61 vein:1.53 lymphnode:0.12 peripheral blood:- spleen:0.45 thymus:0 bone marrow:- adipose:0.78 bone:- skin:-
RNA-seq cerebrum:1.11 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.48 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:22.50 ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:21.20 intestine:- colon:25.40     liver/hepato:10.60        lung:29.30    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.16 placenta:4.11 prostate:3.94 ovary:4.33 testis:4.14 heart:4.28 muscle:4.24 esophagus:4.17 stomach:4.35 intestine:4.52 colon:4.36 liver/hepato:4.04 lung:4.25 bladder:- kidney:4.08 pituitary:4.29 thyroid/parathyroid:4.19 adrenal gland:4 pancreas:4.93 breast:4.04 salivary:4.53
CAGE uterus:1.37 placenta:0.24 prostate:0.97 ovary:1.82 testis:0.84 heart:1.52 muscle:0.40 esophagus:0.94 stomach:- intestine:2.50 colon:1.71     liver/hepato:0.46    lung:1.70 bladder:0.78 kidney:2.07 pituitary:0.50 thyroid/parathyroid:2.58 adrenal gland:- pancreas:2.86 breast:0.90 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.80 testis:0.67 heart:0.90 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.42     liver/hepato:0.05        lung:0.53    bladder:- kidney:1.03 pituitary:- thyroid/parathyroid:1.91 adrenal gland:0.00 pancreas:- breast:0.30 salivary:-

Gene Information

IDs

Refseq ID NM_022114
Gene ID 63976
Unigene ID Hs.99500
Probe set ID 220928_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000142611
GTEx ID ENSG00000142611

Orthologous Gene

Mouse[1]  NM_001177995, NM_027504
Rat[1]  NM_001177995, NM_027504

Chromosomal Region

1p36.32  [2,985,732  -  3,355,185]

Gene Family (Interpro ID)

IPR015880  Zinc finger, C2H2-like
IPR007087  Zinc finger, C2H2-type

Link to Pubmed  (Pubmed ID)

4063527
8547101
11050005
11214970
12168954
12477932
12557231
12816872
14656887
14702039
14712237
16582916
16598304
16637659
18202228
18767145
19049980
19240061
19285866
19505873
19567523
19641492
20101261
20339536
20379614
20634891
21666692
21906983
22039459
22050763
22072275
22383139
22939622
23454374
23524569
23768516
23793025
24021092
24327154
24674449

Gene Ontology  (GO ID)

Biological Process

GO:0050873  brown fat cell differentiation
GO:0030853  negative regulation of granulocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0022008  neurogenesis
GO:0060021  palate development
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0043457  regulation of cellular respiration
GO:0035019  somatic stem cell maintenance
GO:0043586  tongue development
GO:0006351  transcription, DNA-dependent
GO:0050872  white fat cell differentiation

Cellular Component

GO:0005634  nucleus
GO:0017053  transcriptional repressor complex

Molecular Function

GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0046332  SMAD binding
GO:0003713  transcription coactivator activity