solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

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Synonym

SLC11A1, NRAMP1, Natural resistance-associated macrophage protein 1, NRAMP 1, NRAMP, LSH

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:50.40 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:41.10 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:364.40 spleen:132.30 thymus:12.90 bone marrow:39.40 adipose:40.30 bone:51.20 skin:4.80
GeneChip cerebrum:4.21 cerebellum:4.22 brain stem:4.35 corpus callosum/glia:4.15 pineal gland:- peripheral nerve:4.01 spine:4.02 retina:- eye:- artery/aorta:4.03 vein:4.40 lymphnode:4.06 peripheral blood:- spleen:4.03 thymus:4.09 bone marrow:4.56 adipose:4.25 bone:- skin:4.58
CAGE cerebrum:2.61 cerebellum:- brain stem:3.22 corpus callosum/glia:2.70 pineal gland:2.94 peripheral nerve:- spine:4.13 retina:- eye:- artery/aorta:2.62 vein:1.53 lymphnode:2.55 peripheral blood:- spleen:3.81 thymus:0.71 bone marrow:- adipose:3.72 bone:- skin:-
RNA-seq cerebrum:1.51 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.46 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.67 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:40.10 prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:33.90     liver/hepato:-        lung:127.10    bladder:125.60 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:9.30 salivary:-
GeneChip uterus:4.02 placenta:4.06 prostate:3.97 ovary:4.08 testis:4.04 heart:4.45 muscle:4.53 esophagus:4.07 stomach:4.08 intestine:4.19 colon:4.39 liver/hepato:4.10 lung:5.85 bladder:- kidney:4.18 pituitary:3.99 thyroid/parathyroid:3.77 adrenal gland:4.13 pancreas:4.34 breast:3.85 salivary:4.21
CAGE uterus:1.10 placenta:2.20 prostate:1.42 ovary:2.18 testis:1.38 heart:2.22 muscle:1.97 esophagus:1.62 stomach:- intestine:0.99 colon:0.82     liver/hepato:1.79    lung:4.72 bladder:3.07 kidney:2.07 pituitary:1.96 thyroid/parathyroid:1.48 adrenal gland:- pancreas:1.98 breast:1.92 salivary:0.83
RNA-seq uterus:- placenta:- prostate:0.83 ovary:0.41 testis:0.49 heart:0.59 muscle:0.19 esophagus:- stomach:- intestine:- colon:0.64     liver/hepato:0.96        lung:3.56    bladder:- kidney:0.92 pituitary:- thyroid/parathyroid:0.75 adrenal gland:0.67 pancreas:- breast:0.45 salivary:-

IDs

Refseq ID NM_000578
Gene ID 6556
Unigene ID Hs.591607
Probe set ID 217507_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000018280
GTEx ID ENSG00000018280

Orthologous Gene

Mouse[1]  NM_013612
Rat[1]  NM_001031658

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0048002  antigen processing and presentation of peptide antigen
GO:0070574  cadmium ion transmembrane transport
GO:0006876  cellular cadmium ion homeostasis
GO:0006879  cellular iron ion homeostasis
GO:0042742  defense response to bacterium
GO:0050829  defense response to Gram-negative bacterium
GO:0042832  defense response to protozoan
GO:0070839  divalent metal ion export
GO:0006954  inflammatory response
GO:0051701  interaction with host
GO:0032623  interleukin-2 production
GO:0032632  interleukin-3 production
GO:0055072  iron ion homeostasis
GO:0006826  iron ion transport
GO:0043091  L-arginine import
GO:0042116  macrophage activation
GO:0006828  manganese ion transport
GO:0045342  MHC class II biosynthetic process
GO:0048255  mRNA stabilization
GO:0060586  multicellular organismal iron ion homeostasis
GO:0001818  negative regulation of cytokine production
GO:0015707  nitrite transport
GO:0006909  phagocytosis
GO:0001819  positive regulation of cytokine production
GO:0002606  positive regulation of dendritic cell antigen processing and presentation
GO:0010628  positive regulation of gene expression
GO:0032729  positive regulation of interferon-gamma production
GO:0050766  positive regulation of phagocytosis
GO:0002827  positive regulation of T-helper 1 type immune response
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0000060  protein import into nucleus, translocation
GO:0045730  respiratory burst
GO:0009617  response to bacterium
GO:0034341  response to interferon-gamma
GO:0032496  response to lipopolysaccharide
GO:0002369  T cell cytokine production
GO:0002309  T cell proliferation during immune response
GO:0055085  transmembrane transport
GO:0007035  vacuolar acidification
GO:0042060  wound healing

Cellular Component

GO:0009279  cell outer membrane
GO:0005887  integral to plasma membrane
GO:0005770  late endosome
GO:0031902  late endosome membrane
GO:0005764  lysosome
GO:0030670  phagocytic vesicle membrane
GO:0005886  plasma membrane
GO:0070821  tertiary granule membrane

Molecular Function

GO:0005384  manganese ion transmembrane transporter activity
GO:0051139  metal ion:hydrogen antiporter activity
GO:0042803  protein homodimerization activity
GO:0046915  transition metal ion transmembrane transporter activity