solute carrier family 18 (vesicular monoamine), member 2

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Synonym

SVAT, Solute carrier family 18 member 2, Monoamine transporter, MGC26538, SVMT, VAT2, MGC120477, SLC18A2, Vesicular amine transporter 2, VMAT2, Synaptic vesicular amine transporter, MGC120478

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:3.49 cerebellum:3.40 brain stem:6.40 corpus callosum/glia:3.26 pineal gland:- peripheral nerve:3.18 spine:3.18 retina:- eye:- artery/aorta:3.46 vein:3.41 lymphnode:3.69 peripheral blood:- spleen:3.08 thymus:5.19 bone marrow:3.99 adipose:3.58 bone:- skin:3.99
CAGE cerebrum:0.11 cerebellum:- brain stem:1.59 corpus callosum/glia:0.24 pineal gland:0 peripheral nerve:- spine:0.23 retina:- eye:- artery/aorta:0.59 vein:1.49 lymphnode:1.01 peripheral blood:- spleen:0.09 thymus:2.29 bone marrow:- adipose:0.71 bone:- skin:-
RNA-seq cerebrum:2.68 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.06 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.90 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.72 placenta:3.18 prostate:5.31 ovary:4.02 testis:3.25 heart:3.26 muscle:3.45 esophagus:3.73 stomach:4.19 intestine:3.92 colon:3.34 liver/hepato:3.32 lung:4.25 bladder:- kidney:3.04 pituitary:3.09 thyroid/parathyroid:2.99 adrenal gland:3.59 pancreas:4.99 breast:3.61 salivary:3.18
CAGE uterus:2.78 placenta:0.85 prostate:2.27 ovary:1.51 testis:0.78 heart:0.49 muscle:0 esophagus:1.14 stomach:- intestine:0.93 colon:1.20     liver/hepato:0.84    lung:2.09 bladder:1.15 kidney:0.21 pituitary:0.26 thyroid/parathyroid:0.12 adrenal gland:- pancreas:1.21 breast:0.90 salivary:0
RNA-seq uterus:- placenta:- prostate:2.43 ovary:2.59 testis:2.17 heart:1.84 muscle:1.67 esophagus:- stomach:- intestine:- colon:2.14     liver/hepato:3.06        lung:2.77    bladder:- kidney:2.86 pituitary:- thyroid/parathyroid:1.55 adrenal gland:2.10 pancreas:- breast:1.93 salivary:-

Gene Information

IDs

Refseq ID NM_003054
Gene ID 6571
Unigene ID -
Probe set ID 205857_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000165646
GTEx ID ENSG00000165646

Orthologous Gene

Mouse[1]  NM_172523
Rat [0]  

Chromosomal Region

10q25.3  [119,000,604  -  119,038,941]

Gene Family (Interpro ID)

IPR020846  Major facilitator superfamily
IPR016196  Major facilitator superfamily, general substrate transporter

Link to Pubmed  (Pubmed ID)

7905859
8095030
8245983
8373557
8643547
9045708
11279528
11431013
11443533
11997877
12009896
12112084
12477932
12710012
12827358
12871984
15135235
15164054
15475732
15489334
15829504
15850588
15988470
16139173
16189177
16339215
16386370
16408221
17233532
17344033
17427184
17442673
17652604
17665159
17985233
18045777
18288090
18316816
18599602
18791800
18797399
19156168
19228741
19289536
19328558
19460752
19693267
19874574
20080893
20181938
20379614
20468064
20544232
20665056
20677014
21041608
21083670
21139048
21484276
21522164
21814181
21851191
22483869
22532702
22554508
23185343
23221614
23363473
23369548
23404442
23410751
23504072
23504951
23530208
23573890
23932573
24018103

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0071242  cellular response to ammonium ion
GO:0016265  death
GO:0032456  endocytic recycling
GO:0042593  glucose homeostasis
GO:0030073  insulin secretion
GO:0007626  locomotory behavior
GO:0015844  monoamine transport
GO:0051589  negative regulation of neurotransmitter transport
GO:0007269  neurotransmitter secretion
GO:0009791  post-embryonic development
GO:0001975  response to amphetamine
GO:0042220  response to cocaine
GO:0051412  response to corticosterone stimulus
GO:0009635  response to herbicide
GO:0042594  response to starvation
GO:0010043  response to zinc ion
GO:0007268  synaptic transmission
GO:0055085  transmembrane transport

Cellular Component

GO:0043025  cell soma
GO:0070083  clathrin sculpted monoamine transport vesicle membrane
GO:0031045  dense core granule
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0030672  synaptic vesicle membrane
GO:0043195  terminal button

Molecular Function

GO:0005275  amine transmembrane transporter activity
GO:0008144  drug binding
GO:0019899  enzyme binding
GO:0031072  heat shock protein binding
GO:0008504  monoamine transmembrane transporter activity
GO:0015222  serotonin transmembrane transporter activity