smoothened homolog (Drosophila)

 jump to detail

Synonym

SMOH, Smoothened homolog precursor, Gx protein, smoothened homolog (Drosophila), smoothened (Drosophila) homolog, SMO, Gx

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:16.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:76.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:25.80 bone marrow:- adipose:- bone:51.20 skin:4.80
GeneChip cerebrum:5.77 cerebellum:6.07 brain stem:5.78 corpus callosum/glia:5.94 pineal gland:- peripheral nerve:6.07 spine:5.86 retina:- eye:- artery/aorta:5.93 vein:6 lymphnode:5.74 peripheral blood:- spleen:5.62 thymus:5.78 bone marrow:5.75 adipose:5.82 bone:- skin:5.79
CAGE cerebrum:1.29 cerebellum:- brain stem:1.15 corpus callosum/glia:1.58 pineal gland:1.20 peripheral nerve:- spine:2.04 retina:- eye:- artery/aorta:2.28 vein:1.44 lymphnode:1.21 peripheral blood:- spleen:0.66 thymus:1.31 bone marrow:- adipose:1.47 bone:- skin:-
RNA-seq cerebrum:1.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.67 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.03 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:10.90 prostate:22.50 ovary:37.30 testis:4.30 heart:25.50 muscle:20.10 esophagus:- stomach:- intestine:32.40 colon:8.50     liver/hepato:-        lung:4.90    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:8.90 breast:55.80 salivary:-
GeneChip uterus:6.27 placenta:5.57 prostate:5.90 ovary:6.16 testis:5.70 heart:5.97 muscle:6.04 esophagus:6.09 stomach:5.95 intestine:5.89 colon:6.05 liver/hepato:6.17 lung:5.63 bladder:- kidney:6.27 pituitary:6.39 thyroid/parathyroid:6.12 adrenal gland:5.88 pancreas:6.08 breast:5.99 salivary:6.16
CAGE uterus:2.81 placenta:0.99 prostate:2.73 ovary:2.54 testis:1.90 heart:1.56 muscle:1.23 esophagus:2.22 stomach:- intestine:1.31 colon:1.83     liver/hepato:2.08    lung:0.99 bladder:1.80 kidney:2.18 pituitary:2.32 thyroid/parathyroid:2.05 adrenal gland:- pancreas:1.74 breast:1.92 salivary:2.31
RNA-seq uterus:- placenta:- prostate:2.60 ovary:3.89 testis:2.94 heart:0.70 muscle:0.35 esophagus:- stomach:- intestine:- colon:1.84     liver/hepato:2.34        lung:0.80    bladder:- kidney:2.59 pituitary:- thyroid/parathyroid:1.69 adrenal gland:1.41 pancreas:- breast:1.81 salivary:-

Gene Information

IDs

Refseq ID NM_005631
Gene ID 6608
Unigene ID Hs.437846
Probe set ID 218629_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000128602
GTEx ID ENSG00000128602

Orthologous Gene

Mouse[2]  NM_176996
Rat [0]  

Chromosomal Region

7q32.1  [128,828,713  -  128,853,386]

Gene Family (Interpro ID)

IPR000539  Frizzled protein
IPR020067  Frizzled-like domain
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

8898207
8906787
9422511
9581815
9628830
9764827
9799615
9811851
11042037
11278759
11748145
12123571
12165511
12192414
12241103
12477932
12499255
12690205
12773389
15489334
15618519
16147992
16339184
16344560
16804411
16867986
16945339
17850284
17884791
18359851
18502968
18543049
19056867
19237606
19304771
19351817
19401682
19432668
19453261
19473442
19564910
19592253
19726788
19730683
20050020
20067614
20215540
20561215
20603613
20819778
20937227
21210262
21338440
21757753
22114142
22231273
22253573
22486854
22535603
22864913
22901214
23063129
23098507
23334667
23341351
23348505
23349881
23379358
23448715
23508962
23599646
23636324
23915072
24148123
24277750

Gene Ontology  (GO ID)

Biological Process

GO:0021984  adenohypophysis development
GO:0048846  axon extension involved in axon guidance
GO:0010002  cardioblast differentiation
GO:0001708  cell fate specification
GO:0071397  cellular response to cholesterol
GO:0021953  central nervous system neuron differentiation
GO:0021696  cerebellar cortex morphogenesis
GO:0060830  ciliary receptor clustering involved in smoothened signaling pathway
GO:0060248  detection of cell density by contact stimulus involved in contact inhibition
GO:0003140  determination of left/right asymmetry in lateral mesoderm
GO:0007368  determination of left/right symmetry
GO:0021904  dorsal/ventral neural tube patterning
GO:0031076  embryonic camera-type eye development
GO:0048557  embryonic digestive tract morphogenesis
GO:0048702  embryonic neurocranium morphogenesis
GO:0048703  embryonic viscerocranium morphogenesis
GO:0060684  epithelial-mesenchymal cell signaling
GO:0031017  exocrine pancreas development
GO:0021561  facial nerve development
GO:0021508  floor plate formation
GO:0048853  forebrain morphogenesis
GO:0008406  gonad development
GO:0031069  hair follicle morphogenesis
GO:0001947  heart looping
GO:0003007  heart morphogenesis
GO:0001701  in utero embryonic development
GO:0060644  mammary gland epithelial cell differentiation
GO:0007494  midgut development
GO:0035264  multicellular organism growth
GO:0042693  muscle cell fate commitment
GO:0043066  negative regulation of apoptosis
GO:0043392  negative regulation of DNA binding
GO:0030857  negative regulation of epithelial cell differentiation
GO:0010629  negative regulation of gene expression
GO:0051799  negative regulation of hair follicle development
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0001755  neural crest cell migration
GO:0048663  neuron fate commitment
GO:0031102  neuron projection regeneration
GO:0042475  odontogenesis of dentine-containing tooth
GO:0001649  osteoblast differentiation
GO:0032474  otolith morphogenesis
GO:0003323  pancreatic B cell development
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0050679  positive regulation of epithelial cell proliferation
GO:0010628  positive regulation of gene expression
GO:0007228  positive regulation of hh target transcription factor activity
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0002052  positive regulation of neuroblast proliferation
GO:0042307  positive regulation of protein import into nucleus
GO:0045880  positive regulation of smoothened signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0034504  protein localization in nucleus
GO:0050821  protein stabilization
GO:0048752  semicircular canal morphogenesis
GO:0007224  smoothened signaling pathway
GO:0021938  smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation
GO:0021910  smoothened signaling pathway involved in ventral spinal cord patterning
GO:0007283  spermatogenesis
GO:0021794  thalamus development
GO:0001570  vasculogenesis
GO:0007371  ventral midline determination
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005901  caveola
GO:0043025  cell soma
GO:0005929  cilium
GO:0060170  cilium membrane
GO:0005737  cytoplasm
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0043231  intracellular membrane-bounded organelle
GO:0005886  plasma membrane

Molecular Function

GO:0008144  drug binding
GO:0004930  G-protein coupled receptor activity
GO:0005113  patched binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0005119  smoothened binding
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding