SRY (sex determining region Y)-box 2

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Synonym

MGC2413, SRY (sex determining region Y)-box 2, Transcription factor SOX-2, ANOP3, SOX2, MCOPS3

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:248.90 cerebellum:37.80 brain stem:- corpus callosum/glia:874.80 pineal gland:- peripheral nerve:122.70 spine:- retina:118.60 eye:152.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:8.39 cerebellum:6.96 brain stem:8.18 corpus callosum/glia:9.37 pineal gland:- peripheral nerve:7.86 spine:8.96 retina:- eye:- artery/aorta:5.46 vein:5.49 lymphnode:5.88 peripheral blood:- spleen:5.02 thymus:5.17 bone marrow:5.10 adipose:5.33 bone:- skin:5.83
CAGE cerebrum:4.57 cerebellum:- brain stem:4.23 corpus callosum/glia:4.90 pineal gland:3.12 peripheral nerve:- spine:4.83 retina:- eye:- artery/aorta:3.03 vein:0.34 lymphnode:1.63 peripheral blood:- spleen:0 thymus:0.46 bone marrow:- adipose:0.63 bone:- skin:-
RNA-seq cerebrum:4.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.28 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:11.30 ovary:- testis:13 heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:39.10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.37 placenta:5.08 prostate:5.76 ovary:5.65 testis:5.48 heart:5.54 muscle:5.25 esophagus:8.21 stomach:6.02 intestine:5.51 colon:5.43 liver/hepato:5.14 lung:5.42 bladder:- kidney:5.13 pituitary:6.92 thyroid/parathyroid:5.21 adrenal gland:5.37 pancreas:6.04 breast:5.27 salivary:5.48
CAGE uterus:1.05 placenta:0 prostate:1.64 ovary:1.03 testis:1.69 heart:0.32 muscle:0 esophagus:3.57 stomach:- intestine:1.10 colon:0.80     liver/hepato:0    lung:1.81 bladder:0.95 kidney:0.27 pituitary:3.34 thyroid/parathyroid:0.12 adrenal gland:- pancreas:0 breast:0 salivary:2.17
RNA-seq uterus:- placenta:- prostate:0.74 ovary:0.84 testis:0.59 heart:0.13 muscle:0.02 esophagus:- stomach:- intestine:- colon:3.61     liver/hepato:0.03        lung:2.17    bladder:- kidney:0.05 pituitary:- thyroid/parathyroid:0.13 adrenal gland:0.43 pancreas:- breast:0.01 salivary:-

IDs

Refseq ID NM_003106
Gene ID 6657
Unigene ID Hs.518438
Probe set ID 213721_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000181449
GTEx ID ENSG00000181449

Orthologous Gene

Mouse[1]  NM_011443
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

7590241
7849401
8889548
10089404
10729834
10760287
10801796
11358870
12194848
12477932
12612584
12637543
12710953
12732652
12923055
14559893
14655050
14719100
15143193
15146197
15489334
15910596
15920534
16153702
16283891
16344560
16543359
16552336
16596179
16712695
16932809
17136346
17219395
17291498
17334350
17389240
17464316
17506876
17522144
17587179
17898260
17982423
18000303
18027866
18039390
18157115
18162777
18187129
18199879
18268498
18285410
18293417
18366076
18385794
18388306
18393632
18407919
18456656
18474784
18710938
18757296
18831064
18836133
18948646
19061938
19254784
19327014
19396148
19409607
19414369
19427902
19458492
19471311
19483629
19520737
19549847
19554373
19591226
19657699
19661786
19696409
19716157
19723802
19736317
19767420
19787784
19801978
19816951
19876845
19921648
20042675
20057906
20114006
20126410
20138825
20161759
20185800
20211142
20299530
20301477
20301552
20301753
20349085
20368621
20371328
20382729
20384793
20425471
20454695
20494911
20510497
20537983
20631605
20667095
20698766
20709360
20726797
20739473
20824710
20850729
20875870
20879854
20937145
20949537
21048121
21103394
21166886
21190055
21211035
21227461
21251041
21276239
21280222
21304604
21305642
21323603
21376027
21415100
21419292
21433225
21460799
21518820
21531766
21532573
21540835
21549328
21631526
21687954
21689966
21716161
21803132
21804543
21822303
21852325
21919124
21927024
21931300
21940738
21947321
21951286
21962512
22014056
22015605
22046437
22069467
22070920
22171155
22184093
22184289
22200372
22204637
22236193
22265740
22311737
22396547
22401770
22469032
22482508
22539002
22542624
22571403
22576801
22576926
22613719
22615765
22718759
22777760
22791809
22814375
22832207
22847005
22863087
22899289
22899292
22912670
22937156
22941189
22945632
23009336
23060440
23086772
23111103
23135265
23159246
23211052
23213213
23279472
23301671
23307254
23326489
23336432
23349823
23362975
23414798
23424657
23430442
23451179
23462476
23462687
23463365
23510069
23518916
23539445
23541921
23544055
23545177
23549118
23553930
23568430
23596255
23599173
23613102
23613880
23620753
23667531
23701296
23736381
23796710
23815808
23867475
23884650
23895273
23932306
23932716
23972993
24211324
24229625
24233838
24307698
24325912
24508466
24590290
24656096
24659665
24858640

Gene Ontology  (GO ID)

Biological Process

GO:0021984  adenohypophysis development
GO:0060441  branching involved in lung morphogenesis
GO:0007050  cell cycle arrest
GO:0021987  cerebral cortex development
GO:0006325  chromatin organization
GO:0050973  detection of mechanical stimulus involved in equilibrioception
GO:0050910  detection of mechanical stimulus involved in sensory perception of sound
GO:0048852  diencephalon morphogenesis
GO:0001714  endodermal cell fate specification
GO:0001654  eye development
GO:0030900  forebrain development
GO:0021879  forebrain neuron differentiation
GO:0021781  glial cell fate commitment
GO:0048839  inner ear development
GO:0042472  inner ear morphogenesis
GO:0060235  lens induction in camera-type eye
GO:0048286  lung alveolus development
GO:0030539  male genitalia development
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045665  negative regulation of neuron differentiation
GO:0045668  negative regulation of osteoblast differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0048663  neuron fate commitment
GO:0030910  olfactory placode formation
GO:0001649  osteoblast differentiation
GO:0046148  pigment biosynthetic process
GO:0021983  pituitary gland development
GO:0030858  positive regulation of epithelial cell differentiation
GO:0043410  positive regulation of MAPKKK cascade
GO:0002052  positive regulation of neuroblast proliferation
GO:0045666  positive regulation of neuron differentiation
GO:0045747  positive regulation of Notch signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0043281  regulation of caspase activity
GO:0010468  regulation of gene expression
GO:0006355  regulation of transcription, DNA-dependent
GO:0070848  response to growth factor stimulus
GO:0032526  response to retinoic acid
GO:0009611  response to wounding
GO:0060042  retina morphogenesis in camera-type eye
GO:0035019  somatic stem cell maintenance
GO:0043586  tongue development

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0035198  miRNA binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity