SRY (sex determining region Y)-box 4

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Synonym

SRY (sex determining region Y)-box 4, EVI16, SOX4, Transcription factor SOX-4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.88 cerebellum:6.21 brain stem:4.48 corpus callosum/glia:5.16 pineal gland:- peripheral nerve:6.62 spine:5.36 retina:- eye:- artery/aorta:6.48 vein:6.64 lymphnode:6.17 peripheral blood:- spleen:6.80 thymus:10.02 bone marrow:6.47 adipose:7.01 bone:- skin:6.99
CAGE cerebrum:2.57 cerebellum:- brain stem:2.19 corpus callosum/glia:2.70 pineal gland:3.26 peripheral nerve:- spine:2.63 retina:- eye:- artery/aorta:4.11 vein:4.23 lymphnode:3.10 peripheral blood:- spleen:2.89 thymus:5.93 bone marrow:- adipose:4.00 bone:- skin:-
RNA-seq cerebrum:1.02 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.28 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:9.35 placenta:6.76 prostate:8.23 ovary:9.04 testis:7.46 heart:6.75 muscle:4.85 esophagus:5.90 stomach:7.45 intestine:7.78 colon:7.84 liver/hepato:4.42 lung:7.63 bladder:- kidney:7.20 pituitary:6.48 thyroid/parathyroid:7.50 adrenal gland:5.50 pancreas:7.03 breast:8.31 salivary:6.79
CAGE uterus:4.73 placenta:3.46 prostate:4.11 ovary:4.27 testis:4.28 heart:3.42 muscle:2.56 esophagus:2.98 stomach:- intestine:3.32 colon:3.62     liver/hepato:2.38    lung:4.01 bladder:3.58 kidney:3.76 pituitary:2.50 thyroid/parathyroid:3.49 adrenal gland:- pancreas:3.95 breast:4.62 salivary:3.73
RNA-seq uterus:- placenta:- prostate:3.64 ovary:4.87 testis:4.51 heart:1.19 muscle:1.43 esophagus:- stomach:- intestine:- colon:3.26     liver/hepato:0.70        lung:4.73    bladder:- kidney:3.19 pituitary:- thyroid/parathyroid:3.47 adrenal gland:2.39 pancreas:- breast:4.22 salivary:-

Gene Information

IDs

Refseq ID NM_003107
Gene ID 6659
Unigene ID Hs.643910
Probe set ID 201417_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000124766
GTEx ID ENSG00000124766

Orthologous Gene

Mouse[10]  NM_009238
Rat[10]  NM_009238

Chromosomal Region

6p22.3  [21,593,972  -  21,598,847]

Gene Family (Interpro ID)

IPR000910  High mobility group, HMG1/HMG2
IPR009071  High mobility group, superfamily

Link to Pubmed  (Pubmed ID)

1614875
7706298
8268656
8404853
8530483
8889548
9730625
10381369
10729834
10867006
11071752
11127205
11498591
12100890
12125983
12194848
12216117
12477932
14574404
15146197
15345747
15489334
15522200
16341674
16585165
16618720
16631117
16636670
17507571
17875931
17922414
18029348
18504433
18577562
19147588
19153074
19156145
19234109
19322201
19453261
19454010
19487295
19887623
20049565
20080751
20237496
20331975
20400479
20419098
20423819
20952589
21165564
21348951
21533022
21680105
21986941
22084397
22098624
22231735
22510499
22542805
22627767
22689055
22787120
23152540
23251334
23284291
23285187
23301048
23389731
23402613
23482931
23613880
23677061
23916609
23917306
24183681
24435928

Gene Ontology  (GO ID)

Biological Process

GO:0003289  atrial septum primum morphogenesis
GO:0003215  cardiac right ventricle morphogenesis
GO:0003211  cardiac ventricle formation
GO:0071333  cellular response to glucose stimulus
GO:0042769  DNA damage response, detection of DNA damage
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0031018  endocrine pancreas development
GO:0021782  glial cell development
GO:0014009  glial cell proliferation
GO:0042593  glucose homeostasis
GO:0007507  heart development
GO:0060174  limb bud formation
GO:0003183  mitral valve morphogenesis
GO:0060548  negative regulation of cell death
GO:0008285  negative regulation of cell proliferation
GO:0046826  negative regulation of protein export from nucleus
GO:0031397  negative regulation of protein ubiquitination
GO:0001841  neural tube formation
GO:0060563  neuroepithelial cell differentiation
GO:0003357  noradrenergic neuron differentiation
GO:0043065  positive regulation of apoptosis
GO:0008284  positive regulation of cell proliferation
GO:0032024  positive regulation of insulin secretion
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0045727  positive regulation of translation
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0002328  pro-B cell differentiation
GO:0050821  protein stabilization
GO:0031647  regulation of protein stability
GO:0006355  regulation of transcription, DNA-dependent
GO:0001501  skeletal system development
GO:0035019  somatic stem cell maintenance
GO:0021510  spinal cord development
GO:0021522  spinal cord motor neuron differentiation
GO:0048485  sympathetic nervous system development
GO:0030217  T cell differentiation
GO:0060412  ventricular septum morphogenesis
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737  cytoplasm
GO:0005739  mitochondrion
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0005515  protein binding
GO:0003700  transcription factor activity