SP100 nuclear antigen

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Synonym

FLJ00340, SP100, Nuclear dot-associated Sp100 protein, Nuclear autoantigen Sp-100, DKFZp686E07254, SP100 nuclear antigen, Lysp100b, nuclear antigen Sp100, Speckled 100 kDa

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:70.50 artery/aorta:209.80 vein:- lymphnode:202.20 peripheral blood:54.70 spleen:151.30 thymus:167.50 bone marrow:137.80 adipose:161.30 bone:25.60 skin:105.60
GeneChip cerebrum:5.26 cerebellum:5.14 brain stem:5.44 corpus callosum/glia:5.60 pineal gland:- peripheral nerve:6.79 spine:5.59 retina:- eye:- artery/aorta:7.39 vein:7.18 lymphnode:8.36 peripheral blood:- spleen:8.64 thymus:7.58 bone marrow:7.71 adipose:7.30 bone:- skin:6.87
CAGE cerebrum:2.38 cerebellum:- brain stem:3.04 corpus callosum/glia:2.48 pineal gland:2.70 peripheral nerve:- spine:3.54 retina:- eye:- artery/aorta:4.08 vein:4.40 lymphnode:4.44 peripheral blood:- spleen:4.65 thymus:3.77 bone marrow:- adipose:4.40 bone:- skin:-
RNA-seq cerebrum:0.26 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.96 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.05 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:118.50 placenta:102 prostate:146.40 ovary:149.10 testis:26 heart:25.50 muscle:- esophagus:- stomach:297.40 intestine:129.60 colon:110.20     liver/hepato:73.90        lung:102.60    bladder:1004.90 kidney:124.80 pituitary:116 thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:53.30 breast:158 salivary:-
GeneChip uterus:7.34 placenta:6.90 prostate:7.42 ovary:7.67 testis:5.10 heart:7.32 muscle:5.60 esophagus:6.65 stomach:7.27 intestine:6.70 colon:6.57 liver/hepato:7.08 lung:7.82 bladder:- kidney:6.62 pituitary:5.90 thyroid/parathyroid:7.25 adrenal gland:7.74 pancreas:6.47 breast:7.19 salivary:6.93
CAGE uterus:3.85 placenta:3.84 prostate:3.93 ovary:3.89 testis:2.81 heart:4.29 muscle:3.10 esophagus:3.83 stomach:- intestine:4.24 colon:3.68     liver/hepato:3.75    lung:4.48 bladder:4.01 kidney:3.49 pituitary:3.17 thyroid/parathyroid:4.08 adrenal gland:- pancreas:3.34 breast:4.28 salivary:3.80
RNA-seq uterus:- placenta:- prostate:1.52 ovary:1.87 testis:1.49 heart:1.44 muscle:0.84 esophagus:- stomach:- intestine:- colon:1.86     liver/hepato:0.27        lung:1.32    bladder:- kidney:1.11 pituitary:- thyroid/parathyroid:1.28 adrenal gland:1.29 pancreas:- breast:1.31 salivary:-

Gene Information

IDs

Refseq ID NM_003113
Gene ID 6672
Unigene ID Hs.369056
Probe set ID 202864_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000067066
GTEx ID ENSG00000067066

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

2q37.1  [231,280,657  -  231,408,805]

Gene Family (Interpro ID)

IPR000910  High mobility group, HMG1/HMG2
IPR000135  High mobility group, HMG1/HMG2, subgroup
IPR009071  High mobility group, superfamily
IPR000770  SAND
IPR010919  SAND-like
IPR019787  Zinc finger, PHD-finger
IPR001965  Zinc finger, PHD-type

Link to Pubmed  (Pubmed ID)

2258622
8695863
8810287
9230084
9412458
9636146
9636147
9973607
10212234
10766566
10921892
11112690
11313457
11574059
11716541
11792325
11909962
12477932
14647468
14702039
15017387
15247905
15489334
15592518
15608651
15767676
15882967
16177824
16189514
16344560
16415175
16524884
16873258
17000644
17081983
17245429
17332504
17491593
18029348
18691969
19279115
19471022
20130140
20211142
20379614
20512085
20805487
20936779
21044950
21172801
21252943
21274506
21383994
21471311
21693764
21734036
21779164
21880768
21890473
21906983
21988832
22086178
22278248
22419217
22863883
22939629
23000965
23221561
23485562
23830076
23867815
24089549
24194542
24623443
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0019221  cytokine-mediated signaling pathway
GO:0006978  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0051271  negative regulation of cellular component movement
GO:0043392  negative regulation of DNA binding
GO:0010596  negative regulation of endothelial cell migration
GO:0046826  negative regulation of protein export from nucleus
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0032897  negative regulation of viral transcription
GO:0051091  positive regulation of transcription factor activity
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0045765  regulation of angiogenesis
GO:0034097  response to cytokine stimulus
GO:0034341  response to interferon-gamma
GO:0032526  response to retinoic acid
GO:0034340  response to type I interferon
GO:0048384  retinoic acid receptor signaling pathway
GO:0000723  telomere maintenance
GO:0006351  transcription, DNA-dependent
GO:0060337  type I interferon-mediated signaling pathway
GO:0019048  virus-host interaction

Cellular Component

GO:0005737  cytoplasm
GO:0030870  Mre11 complex
GO:0034399  nuclear periphery
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0016605  PML body

Molecular Function

GO:0070087  chromo shadow domain binding
GO:0003677  DNA binding
GO:0042802  identical protein binding
GO:0019900  kinase binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0042803  protein homodimerization activity
GO:0003713  transcription coactivator activity
GO:0003714  transcription corepressor activity
GO:0008134  transcription factor binding