secreted protein, acidic, cysteine-rich (osteonectin)

Synonym

SPARC, Osteonectin, Secreted protein acidic and rich in cysteine, Basement-membrane protein 40, BM-40, ON, SPARC precursor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:596.10

cerebellum:113.30

brain stem:-

corpus callosum/glia:466.60

pineal gland:296.70

peripheral nerve:7729.40

spine:2021.30

retina:1779.60

eye:922.70

artery/aorta:1079.10

vein:3865.60

lymphnode:10.10

peripheral blood:164

spleen:302.50

thymus:64.40

bone marrow:2519.10

adipose:605

bone:2456.60

skin:676.80

GeneChip

cerebrum:8.75

cerebellum:7.98

brain stem:10.04

corpus callosum/glia:9.75

pineal gland:-

peripheral nerve:10.42

spine:10.81

retina:-

eye:-

artery/aorta:10.55

vein:10.62

lymphnode:7.82

peripheral blood:-

spleen:9.24

thymus:6.67

bone marrow:5.10

adipose:10.62

bone:-

skin:9.36

CAGE

cerebrum:6.15

cerebellum:-

brain stem:7.27

corpus callosum/glia:7.18

pineal gland:5.85

peripheral nerve:-

spine:7.84

retina:-

eye:-

artery/aorta:7.58

vein:6.66

lymphnode:5.54

peripheral blood:-

spleen:6.40

thymus:4.56

bone marrow:-

adipose:7.44

bone:-

skin:-

RNA-seq

cerebrum:6.95

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:7.28

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:8.58

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:1130

placenta:1500.90

prostate:337.90

ovary:260.80

testis:726.80

heart:1353.80

muscle:261.20

esophagus:-

stomach:870.90

intestine:162

colon:279.80

liver/hepato:232.20

lung:488.80

bladder:251.20

kidney:187.10

pituitary:463.90

thyroid/parathyroid:163.70

adrenal gland:1168.10

pancreas:346.80

breast:566.90

salivary:-

GeneChip

uterus:10.33

placenta:9.37

prostate:8.99

ovary:9.86

testis:8.77

heart:9.27

muscle:8.56

esophagus:8.49

stomach:8.76

intestine:9.01

colon:8.68

liver/hepato:7.39

lung:9.76

bladder:-

kidney:8.37

pituitary:8.08

thyroid/parathyroid:9.17

adrenal gland:9.45

pancreas:6.95

breast:9.84

salivary:7.26

CAGE

uterus:7.36

placenta:7.54

prostate:6.55

ovary:6.67

testis:7.16

heart:6.80

muscle:5.96

esophagus:6.17

stomach:-

intestine:5.34

colon:5.96

liver/hepato:5.74

lung:6.70

bladder:6.77

kidney:6.45

pituitary:5.17

thyroid/parathyroid:6.03

adrenal gland:-

pancreas:4.64

breast:6.27

salivary:4.94

RNA-seq

uterus:-

placenta:-

prostate:7.17

ovary:8.11

testis:8.56

heart:6.74

muscle:5.45

esophagus:-

stomach:-

intestine:-

colon:8.22

liver/hepato:5.47

lung:9.23

bladder:-

kidney:7.70

pituitary:-

thyroid/parathyroid:6.67

adrenal gland:7.51

pancreas:-

breast:10.42

salivary:-

IDs

Refseq ID	NM_003118
Gene ID	6678
Unigene ID	Hs.111779
Probe set ID	212667_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000113140
GTEx ID	ENSG00000113140

Orthologous Gene

Mouse[2]	NM_009242
Rat [0]

Chromosomal Region

5q33.1 [151,040,657 - 151,066,726]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003645	Follistatin-like, N-terminal
IPR002350	Proteinase inhibitor I1, Kazal

Gene Ontology (GO ID)

Biological Process

GO:0007596	blood coagulation
GO:0060348	bone development
GO:0071363	cellular response to growth factor stimulus
GO:0030198	extracellular matrix organization
GO:0007507	heart development
GO:0048839	inner ear development
GO:0030324	lung development
GO:0001503	ossification
GO:0030168	platelet activation
GO:0002576	platelet degranulation
GO:0042127	regulation of cell proliferation
GO:0046686	response to cadmium ion
GO:0051592	response to calcium ion
GO:0051591	response to cAMP
GO:0034097	response to cytokine stimulus
GO:0045471	response to ethanol
GO:0051384	response to glucocorticoid stimulus
GO:0009629	response to gravity
GO:0033591	response to L-ascorbic acid
GO:0010288	response to lead ion
GO:0032496	response to lipopolysaccharide
GO:0043434	response to peptide hormone stimulus
GO:0007165	signal transduction

Cellular Component

GO:0005604	basement membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0031093	platelet alpha granule lumen
GO:0005578	proteinaceous extracellular matrix

Molecular Function

GO:0005509	calcium ion binding
GO:0005518	collagen binding
GO:0050840	extracellular matrix binding
GO:0005515	protein binding

secreted protein, acidic, cysteine-rich (osteonectin)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function