sterol regulatory element binding transcription factor 2

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Synonym

Sterol regulatory element-binding protein 2, SREBP-2, SREBF2, SREBP2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:94.80

cerebellum:25.20

brain stem:-

corpus callosum/glia:29.20

pineal gland:445

peripheral nerve:30.70

spine:336.90

retina:-

eye:188.10

artery/aorta:-

vein:66.60

lymphnode:202.20

peripheral blood:36.40

spleen:56.70

thymus:77.30

bone marrow:78.70

adipose:80.70

bone:25.60

skin:388.80

GeneChip

cerebrum:7.24

cerebellum:7.65

brain stem:7.15

corpus callosum/glia:7.28

pineal gland:-

peripheral nerve:7.30

spine:7.20

retina:-

eye:-

artery/aorta:6.77

vein:7.13

lymphnode:7.08

peripheral blood:-

spleen:6.90

thymus:6.71

bone marrow:6.84

adipose:6.87

bone:-

skin:7.06

CAGE

cerebrum:5.19

cerebellum:-

brain stem:4.84

corpus callosum/glia:5.14

pineal gland:4.80

peripheral nerve:-

spine:4.59

retina:-

eye:-

artery/aorta:4.47

vein:4.37

lymphnode:4.41

peripheral blood:-

spleen:4.39

thymus:4.30

bone marrow:-

adipose:4.05

bone:-

skin:-

RNA-seq

cerebrum:4.55

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.27

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.35

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:63.80

placenta:76.50

prostate:135.20

ovary:-

testis:47.60

heart:242.70

muscle:20.10

esophagus:-

stomach:106.20

intestine:64.80

colon:254.40

liver/hepato:137.20

lung:68.40

bladder:-

kidney:41.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:106.70

breast:102.20

salivary:-

GeneChip

uterus:6.71

placenta:6.20

prostate:6.99

ovary:6.73

testis:6.97

heart:6.95

muscle:6.58

esophagus:7.42

stomach:7.07

intestine:7.02

colon:7.38

liver/hepato:6.77

lung:7.03

bladder:-

kidney:6.78

pituitary:6.97

thyroid/parathyroid:6.48

adrenal gland:7.48

pancreas:7.15

breast:6.79

salivary:7.06

CAGE

uterus:4.47

placenta:4.14

prostate:4.48

ovary:4.75

testis:4.40

heart:4.28

muscle:3.97

esophagus:5.08

stomach:-

intestine:4.78

colon:4.71

liver/hepato:4.55

lung:4.71

bladder:4.51

kidney:4.60

pituitary:4.25

thyroid/parathyroid:4.23

adrenal gland:-

pancreas:4.29

breast:4.05

salivary:4.94

RNA-seq

uterus:-

placenta:-

prostate:4.02

ovary:4.61

testis:3.75

heart:3.68

muscle:3.68

esophagus:-

stomach:-

intestine:-

colon:3.42

liver/hepato:3.92

lung:4.38

bladder:-

kidney:4.00

pituitary:-

thyroid/parathyroid:3.79

adrenal gland:4.12

pancreas:-

breast:3.38

salivary:-

IDs

Refseq ID	NM_004599
Gene ID	6721
Unigene ID	Hs.443258
Probe set ID	201248_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000198911
GTEx ID	ENSG00000198911

Orthologous Gene

Mouse[2]	NM_033218
Rat[1]	NM_001033694

Chromosomal Region

22q13.2 [42,229,109 - 42,303,312]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0044255	cellular lipid metabolic process
GO:0071499	cellular response to laminar fluid shear stress
GO:0008203	cholesterol metabolic process
GO:0006629	lipid metabolic process
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0010886	positive regulation of cholesterol storage
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055098	response to low-density lipoprotein stimulus
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0000139	Golgi membrane
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0032937	SREBP-SCAP-Insig complex

Molecular Function

GO:0000247	C-8 sterol isomerase activity
GO:0070888	E-box binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0046983	protein dimerization activity
GO:0003700	transcription factor activity

sterol regulatory element binding transcription factor 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function