ADAM metallopeptidase domain 17

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Synonym

MGC71942, TNF-alpha convertase, CD156b, TACE, cSVP, ADAM17, A disintegrin and metalloproteinase domain 17, CD156B, alpha, ADAM 17 precursor, CSVP, TNF-alpha-converting enzyme, Snake venom-like protease, CD156b antigen

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:14.20 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:35.30 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:- spleen:56.70 thymus:38.70 bone marrow:39.40 adipose:40.30 bone:12.80 skin:33.60
GeneChip cerebrum:6 cerebellum:6.58 brain stem:5.64 corpus callosum/glia:6.47 pineal gland:- peripheral nerve:6.57 spine:6.46 retina:- eye:- artery/aorta:6.06 vein:6.17 lymphnode:6.53 peripheral blood:- spleen:6.66 thymus:6.77 bone marrow:5.95 adipose:6.07 bone:- skin:6.62
CAGE cerebrum:2.84 cerebellum:- brain stem:3.01 corpus callosum/glia:3.19 pineal gland:3.19 peripheral nerve:- spine:3.04 retina:- eye:- artery/aorta:3.25 vein:3.02 lymphnode:3.31 peripheral blood:- spleen:3.56 thymus:3.08 bone marrow:- adipose:3.45 bone:- skin:-
RNA-seq cerebrum:2.78 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.22 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:14.60 prostate:22.50 ovary:37.30 testis:34.60 heart:- muscle:- esophagus:- stomach:127.50 intestine:- colon:25.40     liver/hepato:31.70        lung:34.20    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:65.10 salivary:-
GeneChip uterus:6.18 placenta:6.78 prostate:5.88 ovary:6.64 testis:6.60 heart:6.10 muscle:5.66 esophagus:6.33 stomach:5.85 intestine:5.79 colon:5.70 liver/hepato:5.59 lung:7.41 bladder:- kidney:5.89 pituitary:5.87 thyroid/parathyroid:6.45 adrenal gland:6 pancreas:4.69 breast:6.91 salivary:5.25
CAGE uterus:3.21 placenta:3.83 prostate:2.75 ovary:3.43 testis:3.40 heart:3.16 muscle:2.44 esophagus:3.24 stomach:- intestine:2.91 colon:2.93     liver/hepato:2.55    lung:3.69 bladder:3.06 kidney:3.05 pituitary:2.85 thyroid/parathyroid:3.00 adrenal gland:- pancreas:2.76 breast:3.33 salivary:2.97
RNA-seq uterus:- placenta:- prostate:2.69 ovary:3.54 testis:3.53 heart:2.39 muscle:2.62 esophagus:- stomach:- intestine:- colon:2.84     liver/hepato:1.61        lung:3.61    bladder:- kidney:2.67 pituitary:- thyroid/parathyroid:3.48 adrenal gland:2.97 pancreas:- breast:3.00 salivary:-

IDs

Refseq ID NM_003183
Gene ID 6868
Unigene ID Hs.404914
Probe set ID 205745_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000151694
GTEx ID ENSG00000151694

Orthologous Gene

Mouse[3]  NM_009615
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8889548
9034190
9034191
9520379
9574564
9620803
9774383
9806848
9920899
10224132
10433800
10527948
10799478
10860581
10882063
11733179
11741929
11823465
11988096
12044879
12058067
12135369
12147693
12207026
12441351
12474981
12477932
12535668
12568494
12606576
12621058
12668732
12706122
12711607
12714588
12730960
12743035
12755693
12777399
12810728
12832423
12947092
12972643
14532978
14625290
14970227
15066987
15102849
15146197
15182369
15280379
15308656
15309730
15337756
15534001
15691827
15784625
15983030
16034137
16079149
16148149
16179345
16210695
16246259
16279945
16332693
16336275
16376986
16478662
16619241
16641105
16806063
16900751
16912185
16942750
16982746
17010968
17081983
17155946
17170699
17227756
17360351
17405915
17438092
17608729
17655843
17714581
17786981
17942404
17986144
17999917
18029348
18167350
18171982
18238782
18276953
18281553
18355445
18373975
18383040
18396294
18426733
18442814
18483258
18490652
18493210
18600307
18625725
18636124
18638486
18676862
18713734
18818406
18824549
18922903
18978678
18979631
19003995
19082505
19091752
19124506
19150341
19154693
19171023
19253070
19278423
19296470
19298600
19299578
19324423
19376560
19435795
19482949
19515085
19535569
19541935
19564338
19595713
19633828
19666115
19704010
19762488
19772640
19819120
19843672
19875451
19913121
19946888
19949420
19959661
20026129
20059578
20070837
20118276
20180536
20184396
20188673
20221248
20300049
20300969
20359533
20379614
20506406
20551051
20627730
20628086
20634891
20679348
20807704
20811902
20819075
20863729
20871631
20922190
21102583
21153921
21170088
21175594
21240579
21268712
21300824
21359495
21365281
21386996
21407195
21423656
21480393
21501859
21777519
21837402
21865167
21890473
21906983
21925169
21932060
21949123
22010916
22018416
22105359
22139867
22157716
22200661
22268729
22319627
22367719
22384041
22438584
22479555
22506015
22550340
22575642
22613720
22665490
22668812
22677042
22689693
22770404
22772468
22833676
22927435
22933306
22934512
22965144
22967992
23000965
23011796
23076445
23105116
23317503
23341882
23349873
23356982
23360525
23384719
23389772
23415892
23416080
23441135
23460612
23475633
23479224
23487023
23500026
23521534
23526433
23545805
23557259
23563789
23585341
23625205
23674691
23684931
23729230
23746173
23897050
23910172
24027752
24044434
24121505
24130797
24159190
24185966
24189063
24227843
24247244
24286866
24337742
24338472
24412389
24518602
24813629

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0030183  B cell differentiation
GO:0007155  cell adhesion
GO:0033627  cell adhesion mediated by integrin
GO:0048870  cell motility
GO:0030574  collagen catabolic process
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0022617  extracellular matrix disassembly
GO:0030198  extracellular matrix organization
GO:0002467  germinal center formation
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0006509  membrane protein ectodomain proteolysis
GO:0031293  membrane protein intracellular domain proteolysis
GO:0032717  negative regulation of interleukin-8 production
GO:0048011  nerve growth factor receptor signaling pathway
GO:0002446  neutrophil mediated immunity
GO:0007219  Notch signaling pathway
GO:0051088  PMA-inducible membrane protein ectodomain proteolysis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0051272  positive regulation of cellular component movement
GO:0032722  positive regulation of chemokine production
GO:0031659  positive regulation of cyclin-dependent protein kinase activity during G1/S
GO:0045741  positive regulation of epidermal growth factor receptor activity
GO:0002690  positive regulation of leukocyte chemotaxis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0010820  positive regulation of T cell chemotaxis
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033025  regulation of mast cell apoptosis
GO:0042493  response to drug
GO:0055099  response to high density lipoprotein stimulus
GO:0001666  response to hypoxia
GO:0032496  response to lipopolysaccharide
GO:0048536  spleen development
GO:0033077  T cell differentiation in the thymus
GO:0035313  wound healing, spreading of epidermal cells

Cellular Component

GO:0015629  actin cytoskeleton
GO:0016324  apical plasma membrane
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005925  focal adhesion
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0005178  integrin binding
GO:0005138  interleukin-6 receptor binding
GO:0004222  metalloendopeptidase activity
GO:0008237  metallopeptidase activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0017124  SH3 domain binding
GO:0008270  zinc ion binding