T-box 3

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Synonym

TBX3, XHL, T-box transcription factor TBX3, UMS, T-box protein 3, T-box 3 (ulnar mammary syndrome), TBX3-ISO

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.01 cerebellum:3.95 brain stem:4.12 corpus callosum/glia:3.96 pineal gland:- peripheral nerve:4.79 spine:3.96 retina:- eye:- artery/aorta:4.70 vein:4.38 lymphnode:4.95 peripheral blood:- spleen:5.39 thymus:3.69 bone marrow:3.91 adipose:5.50 bone:- skin:5.40
CAGE cerebrum:1.61 cerebellum:- brain stem:1.74 corpus callosum/glia:2.06 pineal gland:2.03 peripheral nerve:- spine:2.06 retina:- eye:- artery/aorta:2.46 vein:2.83 lymphnode:2.18 peripheral blood:- spleen:2.44 thymus:1.18 bone marrow:- adipose:2.85 bone:- skin:-
RNA-seq cerebrum:0.28 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.74 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.29 placenta:9.03 prostate:9.45 ovary:5.90 testis:3.68 heart:5.46 muscle:4.70 esophagus:4.56 stomach:4.72 intestine:5.27 colon:5.52 liver/hepato:6.85 lung:6.38 bladder:- kidney:5.50 pituitary:5.36 thyroid/parathyroid:8.29 adrenal gland:10.27 pancreas:3.85 breast:7.11 salivary:5.99
CAGE uterus:4.21 placenta:5.51 prostate:4.93 ovary:4.02 testis:2.60 heart:3.38 muscle:2.69 esophagus:2.20 stomach:- intestine:4.31 colon:3.28     liver/hepato:3.89    lung:4.15 bladder:4.30 kidney:2.82 pituitary:1.87 thyroid/parathyroid:4.90 adrenal gland:- pancreas:0.94 breast:4.43 salivary:3.59
RNA-seq uterus:- placenta:- prostate:2.36 ovary:2.06 testis:1.13 heart:0.52 muscle:1.03 esophagus:- stomach:- intestine:- colon:0.53     liver/hepato:2.17        lung:1.25    bladder:- kidney:1.87 pituitary:- thyroid/parathyroid:3.89 adrenal gland:0.22 pancreas:- breast:1.87 salivary:-

Gene Information

IDs

Refseq ID NM_016569
Gene ID 6926
Unigene ID -
Probe set ID 219682_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135111
GTEx ID ENSG00000135111

Orthologous Gene

Mouse[2]  NM_011535, NM_198052
Rat[1]  NM_181638, NM_198052

Chromosomal Region

12q24.21  [115,108,059  -  115,121,969]

Gene Family (Interpro ID)

IPR002070  Transcription factor, Brachyury
IPR001699  Transcription factor, T-box

Link to Pubmed  (Pubmed ID)

8988164
9207801
10330342
10468588
11689487
11748239
12000749
12005433
12032820
12116211
12477932
12668170
14702039
15289316
15489334
16049973
16530712
16556916
16955224
17081983
17234970
17273972
18029348
18245468
18726671
18829543
19218121
19322201
19403417
19430479
19453261
19913121
20062060
20133910
20414254
20467438
20628086
20702496
20936779
20942798
21045733
21098263
21160077
21199695
21538160
21572416
21784138
21909110
22154512
22284968
22532574
22865636
23082988
23116943
23190890
23266556
23388722
23656610
23667531
24025717
24098938

Gene Ontology  (GO ID)

Biological Process

GO:0003167  atrioventricular bundle cell differentiation
GO:0001568  blood vessel development
GO:0060444  branching involved in mammary gland duct morphogenesis
GO:0060923  cardiac muscle cell fate commitment
GO:0007569  cell aging
GO:0008595  determination of anterior/posterior axis, embryo
GO:0042733  embryonic digit morphogenesis
GO:0035115  embryonic forelimb morphogenesis
GO:0030540  female genitalia development
GO:0046884  follicle-stimulating hormone secretion
GO:0035136  forelimb morphogenesis
GO:0001947  heart looping
GO:0001701  in utero embryonic development
GO:0021761  limbic system development
GO:0032275  luteinizing hormone secretion
GO:0030539  male genitalia development
GO:0030879  mammary gland development
GO:0060596  mammary placode formation
GO:0048332  mesoderm morphogenesis
GO:0043066  negative regulation of apoptosis
GO:0030857  negative regulation of epithelial cell differentiation
GO:0045662  negative regulation of myoblast differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0009887  organ morphogenesis
GO:0003151  outflow tract morphogenesis
GO:0060021  palate development
GO:0045787  positive regulation of cell cycle
GO:0008284  positive regulation of cell proliferation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0060931  sinoatrial node cell development
GO:0001501  skeletal system development
GO:0010159  specification of organ position
GO:0019827  stem cell maintenance
GO:0006351  transcription, DNA-dependent
GO:0060412  ventricular septum morphogenesis

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity