teratocarcinoma-derived growth factor 1

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Synonym

Epidermal growth factor-like cripto protein CR1, CRGF, Cripto-1, Cripto-1 growth factor, CRIPTO, TDGF1, teratocarcinoma-derived growth factor 1, Teratocarcinoma-derived growth factor 1 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:16.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:18.90 thymus:12.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.29 cerebellum:5.29 brain stem:5.38 corpus callosum/glia:5.24 pineal gland:- peripheral nerve:5.06 spine:5.16 retina:- eye:- artery/aorta:4.97 vein:5.16 lymphnode:5.06 peripheral blood:- spleen:7.79 thymus:6.66 bone marrow:5.05 adipose:4.90 bone:- skin:4.97
CAGE cerebrum:0.04 cerebellum:- brain stem:0.03 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.18 vein:0.88 lymphnode:0.03 peripheral blood:- spleen:1.48 thymus:0.57 bone marrow:- adipose:0.26 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:- prostate:11.30 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.11 placenta:4.84 prostate:4.74 ovary:5.96 testis:4.90 heart:5.18 muscle:5.47 esophagus:4.90 stomach:5.56 intestine:5.30 colon:5.78 liver/hepato:5.28 lung:5.10 bladder:- kidney:6.69 pituitary:4.97 thyroid/parathyroid:5.11 adrenal gland:5.83 pancreas:5.32 breast:4.81 salivary:5.49
CAGE uterus:0.04 placenta:0.08 prostate:0.08 ovary:0.79 testis:0.07 heart:0.12 muscle:0.05 esophagus:0.33 stomach:- intestine:0 colon:0.08     liver/hepato:0.14    lung:0 bladder:0 kidney:0.98 pituitary:0 thyroid/parathyroid:0.17 adrenal gland:- pancreas:0 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0.77 testis:0.05 heart:0.13 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.18     liver/hepato:0.00        lung:0.00    bladder:- kidney:1.14 pituitary:- thyroid/parathyroid:0.06 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_003212
Gene ID 6997
Unigene ID Hs.385870
Probe set ID 206286_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000241186
GTEx ID ENSG00000241186

Orthologous Gene

Mouse[1]  NM_011562
Rat[1]  NM_011562

Chromosomal Region

3p21.31  [46,616,045  -  46,623,953]

Gene Family (Interpro ID)

IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

1882841
2792079
7860072
8006041
8314343
8543395
9013573
9576836
9876177
10070255
10393436
10493495
11485994
11857442
11909953
12052855
12073012
12477932
12649175
12682303
12919325
12925698
14581455
14584041
15340161
16169070
16176936
16344560
16951234
16954206
17030617
17207965
17291450
17720976
17925387
17941089
18089557
18312357
19035567
19082438
19386982
19421146
19727905
19732464
19853938
19874624
20126975
20128024
20301702
20379614
20385969
20549704
20629020
21055389
21496809
21824804
21863025
21988832
22306319
22542493
23022962
23034635
23129342
23574716
24379580

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0030509  BMP signaling pathway
GO:0055007  cardiac muscle cell differentiation
GO:0030154  cell differentiation
GO:0002042  cell migration involved in sprouting angiogenesis
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0071346  cellular response to interferon-gamma
GO:0071354  cellular response to interleukin-6
GO:0071356  cellular response to tumor necrosis factor
GO:0008595  determination of anterior/posterior axis, embryo
GO:0009790  embryonic development
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0007369  gastrulation
GO:0007507  heart development
GO:0001701  in utero embryonic development
GO:0030879  mammary gland development
GO:0001763  morphogenesis of a branching structure
GO:0043066  negative regulation of apoptosis
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0018105  peptidyl-serine phosphorylation
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0010595  positive regulation of endothelial cell migration
GO:0048146  positive regulation of fibroblast proliferation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0009966  regulation of signal transduction
GO:0001570  vasculogenesis
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0031225  anchored to membrane
GO:0016324  apical plasma membrane
GO:0009986  cell surface
GO:0005615  extracellular space
GO:0019897  extrinsic to plasma membrane
GO:0005794  Golgi apparatus
GO:0045121  membrane raft
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0008083  growth factor activity
GO:0005515  protein binding
GO:0005102  receptor binding