telomeric repeat binding factor (NIMA-interacting) 1

Synonym

t-TRF1, TRBF1, TERF1, Telomeric repeat-binding factor 1, PIN2, TTAGGG repeat-binding factor 1, Telomeric repeat binding factor 1 (TRF1), hTRF1-AS, NIMA-interacting protein 2, TRF, Telomeric protein Pin2/TRF1, TRF1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:51

cerebellum:63

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:61.30

spine:112.30

retina:-

eye:76.40

artery/aorta:-

vein:-

lymphnode:20.20

peripheral blood:18.20

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:14.40

GeneChip

cerebrum:6.43

cerebellum:6.39

brain stem:6.47

corpus callosum/glia:6.48

pineal gland:-

peripheral nerve:7.09

spine:6.64

retina:-

eye:-

artery/aorta:6.34

vein:6.26

lymphnode:6.16

peripheral blood:-

spleen:6.34

thymus:6.57

bone marrow:5.88

adipose:6.01

bone:-

skin:6

CAGE

cerebrum:4.10

cerebellum:-

brain stem:3.81

corpus callosum/glia:3.55

pineal gland:4.39

peripheral nerve:-

spine:4.24

retina:-

eye:-

artery/aorta:3.49

vein:3.47

lymphnode:3.13

peripheral blood:-

spleen:3.41

thymus:3.71

bone marrow:-

adipose:3.39

bone:-

skin:-

RNA-seq

cerebrum:1.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.03

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.35

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:100.20

placenta:43.70

prostate:33.80

ovary:37.30

testis:34.60

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:64.80

colon:8.50

liver/hepato:52.80

lung:44

bladder:-

kidney:62.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:71.10

breast:18.60

salivary:-

GeneChip

uterus:6.72

placenta:5.28

prostate:7.39

ovary:6.88

testis:5.95

heart:5.99

muscle:5.23

esophagus:5.61

stomach:6.38

intestine:5.72

colon:4.97

liver/hepato:5.56

lung:5.91

bladder:-

kidney:5.93

pituitary:6.45

thyroid/parathyroid:6.24

adrenal gland:6.36

pancreas:5.31

breast:6.31

salivary:5.67

CAGE

uterus:3.74

placenta:2.94

prostate:3.74

ovary:3.78

testis:3.54

heart:3.66

muscle:3.24

esophagus:3.32

stomach:-

intestine:3.35

colon:3.27

liver/hepato:3.46

lung:3.35

bladder:3.93

kidney:3.62

pituitary:4.16

thyroid/parathyroid:3.40

adrenal gland:-

pancreas:3.37

breast:3.52

salivary:3.17

RNA-seq

uterus:-

placenta:-

prostate:3.50

ovary:3.44

testis:3.14

heart:2.21

muscle:1.48

esophagus:-

stomach:-

intestine:-

colon:2.92

liver/hepato:2.18

lung:2.19

bladder:-

kidney:2.60

pituitary:-

thyroid/parathyroid:2.76

adrenal gland:2.91

pancreas:-

breast:2.67

salivary:-

IDs

Refseq ID	NM_003218
Gene ID	7013
Unigene ID	Hs.442707
Probe set ID	203449_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000147601
GTEx ID	ENSG00000147601

Orthologous Gene

Mouse[2]	NM_009352
Rat[1]	NM_001012464

Chromosomal Region

8q21.11 [73,921,099 - 73,960,357]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR009057	Homeodomain-like
IPR012287	Homeodomain-related
IPR017877	MYB-like
IPR001005	SANT, DNA-binding

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0001309	age-dependent telomere shortening
GO:0051301	cell division
GO:0000086	G2/M transition of mitotic cell cycle
GO:0007067	mitosis
GO:0007094	mitotic cell cycle spindle assembly checkpoint
GO:0008156	negative regulation of DNA replication
GO:0051974	negative regulation of telomerase activity
GO:0032214	negative regulation of telomere maintenance via semi-conservative replication
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0031116	positive regulation of microtubule polymerization
GO:0045840	positive regulation of mitosis
GO:0045931	positive regulation of mitotic cell cycle
GO:0051260	protein homooligomerization
GO:0042493	response to drug
GO:0000723	telomere maintenance
GO:0007004	telomere maintenance via telomerase
GO:0010834	telomere maintenance via telomere shortening

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005737	cytoplasm
GO:0000783	nuclear telomere cap complex
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0005819	spindle

Molecular Function

GO:0008656	caspase activator activity
GO:0003682	chromatin binding
GO:0008301	DNA bending activity
GO:0003677	DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0008017	microtubule binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0042803	protein homodimerization activity
GO:0010521	telomerase inhibitor activity
GO:0042162	telomeric DNA binding

telomeric repeat binding factor (NIMA-interacting) 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function