transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

 jump to detail

Synonym

Activating enhancer-binding protein 2 beta, Transcription factor AP-2 beta, CHAR, AP2-beta, AP2-B, AP-2B, TFAP2B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.90 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:170.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:14.40
GeneChip cerebrum:3.26 cerebellum:4.38 brain stem:3.34 corpus callosum/glia:3.20 pineal gland:- peripheral nerve:3.07 spine:3.30 retina:- eye:- artery/aorta:3.13 vein:3.55 lymphnode:3.55 peripheral blood:- spleen:2.98 thymus:2.82 bone marrow:3.20 adipose:3.44 bone:- skin:5.05
CAGE cerebrum:0.36 cerebellum:- brain stem:0.19 corpus callosum/glia:0.13 pineal gland:0.14 peripheral nerve:- spine:0.98 retina:- eye:- artery/aorta:0.18 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0.06 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.02 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:- ovary:- testis:4.30 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:65.10 salivary:-
GeneChip uterus:3.13 placenta:3.27 prostate:3.18 ovary:3.11 testis:3.61 heart:3.26 muscle:3.32 esophagus:4.63 stomach:3.06 intestine:3.23 colon:3.26 liver/hepato:3.15 lung:3.32 bladder:- kidney:6.42 pituitary:3.29 thyroid/parathyroid:3.05 adrenal gland:3.74 pancreas:3.91 breast:6.54 salivary:5.79
CAGE uterus:0.16 placenta:0 prostate:0.15 ovary:0 testis:1.43 heart:0.03 muscle:0 esophagus:2.40 stomach:- intestine:0 colon:0.04     liver/hepato:0    lung:0 bladder:0.18 kidney:3.15 pituitary:0.10 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:2.99 salivary:2.75
RNA-seq uterus:- placenta:- prostate:0.30 ovary:0.01 testis:1.04 heart:0 muscle:0.02 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0.01        lung:0    bladder:- kidney:2.60 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0.58 salivary:-

Gene Information

IDs

Refseq ID NM_003221
Gene ID 7021
Unigene ID Hs.33102
Probe set ID 214451_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000008196
GTEx ID ENSG00000008196

Orthologous Gene

Mouse[2]  NM_001025305, NM_009334
Rat[1]  NM_001106896, NM_009334

Chromosomal Region

6p12.3  [50,786,436  -  50,815,326]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7555706
7559606
7729426
8661133
8889548
9271117
10802654
11278660
11505339
11694877
11744733
12072434
12169688
12192491
12228234
12270648
12477932
12586840
14574404
14673213
15057523
15245963
15489334
15569994
15722186
15940393
16169070
16344560
16373396
16420676
16698963
16787706
16954217
17123722
17185054
17525748
17574780
17630431
17728669
18358611
18752453
19115315
19184334
19325541
19336370
19557161
19778525
20019683
20211142
20301285
20607706
20703240
20724581
20935630
21110914
21139048
21215182
21386085
21504541
21643846
21674055
21766608
21935397
21963094
22199100
22797727
22952648
22959235
23563607
24081236
24250222
24507797

Gene Ontology  (GO ID)

Biological Process

GO:0055074  calcium ion homeostasis
GO:0045444  fat cell differentiation
GO:0035136  forelimb morphogenesis
GO:0042593  glucose homeostasis
GO:0006006  glucose metabolic process
GO:0035137  hindlimb morphogenesis
GO:0001822  kidney development
GO:0010960  magnesium ion homeostasis
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0008285  negative regulation of cell proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0055062  phosphate ion homeostasis
GO:0008284  positive regulation of cell proliferation
GO:0043525  positive regulation of neuron apoptosis
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0055075  potassium ion homeostasis
GO:0030510  regulation of BMP signaling pathway
GO:0045595  regulation of cell differentiation
GO:0050796  regulation of insulin secretion
GO:0006355  regulation of transcription, DNA-dependent
GO:0003091  renal water homeostasis
GO:0010842  retina layer formation
GO:0043588  skin development
GO:0055078  sodium ion homeostasis
GO:0048485  sympathetic nervous system development

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0043027  caspase inhibitor activity
GO:0003677  DNA binding
GO:0005515  protein binding
GO:0046983  protein dimerization activity
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0043565  sequence-specific DNA binding
GO:0003713  transcription coactivator activity
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity