transforming growth factor, beta receptor III

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Synonym

TGFbeta RIII, type III TGFb receptor, TGFbetaRIII, Betaglycan, TGF-beta RIII, TGFbR3, TGFbeta type III receptor, TGFb type III receptor, TGFbeta receptor type III, TGFbRIII, TGF beta RIII, TGF-beta receptor type III precursor, TGFBR3, TGF-beta type III receptor, TGFBRIII, TGF-b receptor type III, TGF-beta receptor type III, type III TGF-b receptor, type III TGF beta receptor, type III TGF-beta receptor, TGFR-3, TGFb receptor type III, TGF-b type III receptor, type III transforming growth factor beta receptor, Transforming growth factor beta receptor III

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:58.10 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:184 spine:112.30 retina:118.60 eye:64.60 artery/aorta:60 vein:- lymphnode:- peripheral blood:- spleen:56.70 thymus:116 bone marrow:78.70 adipose:201.70 bone:127.90 skin:86.40
GeneChip cerebrum:5.48 cerebellum:4.80 brain stem:5.28 corpus callosum/glia:5.91 pineal gland:- peripheral nerve:7.76 spine:6.88 retina:- eye:- artery/aorta:7.90 vein:8.53 lymphnode:7 peripheral blood:- spleen:9.21 thymus:6.39 bone marrow:5.60 adipose:8.91 bone:- skin:8.39
CAGE cerebrum:2.32 cerebellum:- brain stem:2.16 corpus callosum/glia:2.77 pineal gland:3.57 peripheral nerve:- spine:2.97 retina:- eye:- artery/aorta:3.93 vein:4.00 lymphnode:3.46 peripheral blood:- spleen:4.65 thymus:1.74 bone marrow:- adipose:5.08 bone:- skin:-
RNA-seq cerebrum:0.84 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.96 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.99 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:209.60 placenta:204 prostate:56.30 ovary:37.30 testis:47.60 heart:51.10 muscle:20.10 esophagus:- stomach:85 intestine:- colon:17     liver/hepato:137.20        lung:156.40    bladder:- kidney:124.80 pituitary:232 thyroid/parathyroid:- adrenal gland:50.80 pancreas:53.30 breast:46.50 salivary:-
GeneChip uterus:8.41 placenta:9.16 prostate:7.63 ovary:8.98 testis:6.31 heart:7.70 muscle:6.72 esophagus:7.78 stomach:7.79 intestine:7.42 colon:7.31 liver/hepato:7.40 lung:8.87 bladder:- kidney:8.14 pituitary:6.48 thyroid/parathyroid:7.29 adrenal gland:9.08 pancreas:6.48 breast:9.26 salivary:7.99
CAGE uterus:4.68 placenta:4.40 prostate:4.52 ovary:5.49 testis:3.74 heart:4.16 muscle:4.19 esophagus:4.46 stomach:- intestine:3.36 colon:4.00     liver/hepato:3.71    lung:4.41 bladder:5.05 kidney:3.55 pituitary:2.93 thyroid/parathyroid:3.33 adrenal gland:- pancreas:3.45 breast:5.53 salivary:3.73
RNA-seq uterus:- placenta:- prostate:4.26 ovary:4.92 testis:2.86 heart:1.32 muscle:0.60 esophagus:- stomach:- intestine:- colon:4.24     liver/hepato:0.25        lung:4.44    bladder:- kidney:1.49 pituitary:- thyroid/parathyroid:2.76 adrenal gland:2.91 pancreas:- breast:3.78 salivary:-

Gene Information

IDs

Refseq ID NM_003243
Gene ID 7049
Unigene ID Hs.482390
Probe set ID 204731_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000069702
GTEx ID ENSG00000069702

Orthologous Gene

Mouse[1]  NM_011578
Rat [0]  

Chromosomal Region

1p22.1  [92,145,902  -  92,371,892]

Gene Family (Interpro ID)

IPR001507  Endoglin/CD105 antigen
IPR017976  Endoglin/CD105 antigen subgroup

Link to Pubmed  (Pubmed ID)

1319842
1333192
1657406
1657407
7852346
7935686
8106553
8125298
8530052
10092230
10207840
10746731
10944857
11157754
11323414
11382746
11546783
12358857
12385827
12477932
12568406
12651901
12782414
12873459
12958365
12970754
14557487
14585090
14704634
14976204
15009106
15489334
15745937
16344560
16502470
16613887
16621788
16710414
16886151
16982625
17084394
17192875
17272393
17408468
17602227
17999987
18029348
18097622
18174230
18184661
18299279
18315732
18397882
18398939
18845534
18931647
18978678
19056867
19131638
19164448
19249006
19299629
19322201
19416857
19453261
19639191
19842711
19913121
20153821
20178540
20208565
20379614
20386084
20406198
20424473
20548946
20587546
20628086
20634891
20677641
20734064
21186301
21261473
21297076
21307088
21411633
21717526
21756058
21829018
21847367
22036907
22140272
22290546
22300218
22440163
22479366
22562249
22927969
23092981
23209189
23226100
23322721
23835618
24216509
24347165
24658685

Gene Ontology  (GO ID)

Biological Process

GO:0001824  blastocyst development
GO:0001568  blood vessel development
GO:0030509  BMP signaling pathway
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0060038  cardiac muscle cell proliferation
GO:0016049  cell growth
GO:0016477  cell migration
GO:0060318  definitive erythrocyte differentiation
GO:0060216  definitive hemopoiesis
GO:0001837  epithelial to mesenchymal transition
GO:0003007  heart morphogenesis
GO:0060347  heart trabecula formation
GO:0006955  immune response
GO:0001889  liver development
GO:0051271  negative regulation of cellular component movement
GO:0010633  negative regulation of epithelial cell migration
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100  organ regeneration
GO:0060021  palate development
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0007243  protein kinase cascade
GO:0043393  regulation of protein binding
GO:0032354  response to follicle-stimulating hormone stimulus
GO:0001666  response to hypoxia
GO:0034699  response to luteinizing hormone stimulus
GO:0034695  response to prostaglandin E stimulus
GO:0007181  transforming growth factor beta receptor complex assembly
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0009986  cell surface
GO:0005783  endoplasmic reticulum
GO:0009897  external side of plasma membrane
GO:0005615  extracellular space
GO:0034673  inhibin-betaglycan-ActRII complex
GO:0005887  integral to plasma membrane
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0048185  activin binding
GO:0015026  coreceptor activity
GO:0017134  fibroblast growth factor binding
GO:0005539  glycosaminoglycan binding
GO:0008201  heparin binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0046332  SMAD binding
GO:0050431  transforming growth factor beta binding
GO:0005024  transforming growth factor beta receptor activity
GO:0070123  transforming growth factor beta receptor activity, type III
GO:0005160  transforming growth factor beta receptor binding
GO:0005114  type II transforming growth factor beta receptor binding