translocator protein (18kDa)

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Synonym

translocator protein (18kDa), TSPO, PKBS, benzodiazapine receptor (peripheral), PBR, Mitochondrial benzodiazepine receptor, pk18, mDRC, MBR, Peripheral-type benzodiazepine receptor, BZRP, DBI, PTBR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:22.50 cerebellum:25.20 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:61.30 spine:224.60 retina:237.30 eye:29.40 artery/aorta:30 vein:- lymphnode:50.60 peripheral blood:- spleen:- thymus:77.30 bone marrow:- adipose:- bone:51.20 skin:52.80
GeneChip cerebrum:6.57 cerebellum:6.23 brain stem:6.70 corpus callosum/glia:7.41 pineal gland:- peripheral nerve:8.12 spine:7.37 retina:- eye:- artery/aorta:8.46 vein:8.18 lymphnode:8.41 peripheral blood:- spleen:7.97 thymus:7.23 bone marrow:10.09 adipose:9.21 bone:- skin:9.48
CAGE cerebrum:2.45 cerebellum:- brain stem:3.00 corpus callosum/glia:3.20 pineal gland:2.18 peripheral nerve:- spine:3.27 retina:- eye:- artery/aorta:3.98 vein:3.61 lymphnode:4.43 peripheral blood:- spleen:3.84 thymus:2.75 bone marrow:- adipose:4.16 bone:- skin:-
RNA-seq cerebrum:1.83 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.89 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.55 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:51 prostate:33.80 ovary:111.80 testis:112.50 heart:12.80 muscle:40.20 esophagus:- stomach:42.50 intestine:32.40 colon:50.90     liver/hepato:52.80        lung:14.70    bladder:125.60 kidney:114.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:55.80 salivary:-
GeneChip uterus:8.08 placenta:7.21 prostate:8.48 ovary:7.92 testis:6.45 heart:7.98 muscle:7.17 esophagus:10.30 stomach:8.44 intestine:8.19 colon:8.89 liver/hepato:6.80 lung:9.43 bladder:- kidney:7.80 pituitary:7.15 thyroid/parathyroid:7.96 adrenal gland:8 pancreas:7.64 breast:8.97 salivary:8.66
CAGE uterus:3.56 placenta:3.34 prostate:3.85 ovary:3.28 testis:2.79 heart:3.89 muscle:2.96 esophagus:4.99 stomach:- intestine:3.78 colon:4.30     liver/hepato:3.59    lung:4.38 bladder:3.42 kidney:3.53 pituitary:2.30 thyroid/parathyroid:3.48 adrenal gland:- pancreas:3.13 breast:4.58 salivary:3.82
RNA-seq uterus:- placenta:- prostate:3.81 ovary:2.38 testis:2.79 heart:2.55 muscle:1.21 esophagus:- stomach:- intestine:- colon:4.11     liver/hepato:1.98        lung:3.02    bladder:- kidney:3.27 pituitary:- thyroid/parathyroid:2.97 adrenal gland:3.62 pancreas:- breast:4.49 salivary:-

Gene Information

IDs

Refseq ID NM_007311
Gene ID 706
Unigene ID Hs.202001
Probe set ID 202096_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100300
GTEx ID ENSG00000100300

Orthologous Gene

Mouse[3]  NM_009775
Rat [0]  

Chromosomal Region

22q13.2  [43,547,520  -  43,559,248]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1326278
1654492
1847678
3018615
7626442
7721091
8121239
8307574
9027587
9915832
10591208
11215759
11304832
12374690
12477932
12547158
14584048
14626449
14630713
14688214
15041726
15296476
15461802
15473257
15489334
15648546
15769477
16189298
16511838
16822554
16868661
16919618
17561806
18054208
18158327
18256758
18670869
18791274
18806692
19056867
19077109
19170196
19525461
19525468
19598235
19617321
19668118
19692168
19789311
19846611
20056222
20085808
20222126
20424634
20491643
20600583
20872081
20877624
21139048
21320609
21498529
21958735
22008728
22050847
22127435
22238156
22348616
22472607
22547081
22616995
22629859
22645299
22732722
22892349
22956240
22968319
23080515
23281426
23718075
23785173
23850810
23942012
23967175
24050790
24403586
24599476

Gene Ontology  (GO ID)

Biological Process

GO:0030325  adrenal gland development
GO:0007568  aging
GO:0006820  anion transport
GO:0006915  apoptosis
GO:0014012  axon regeneration in the peripheral nervous system
GO:0048266  behavioral response to pain
GO:0008283  cell proliferation
GO:0071476  cellular hypotonic response
GO:0071222  cellular response to lipopolysaccharide
GO:0071294  cellular response to zinc ion
GO:0060242  contact inhibition
GO:0008347  glial cell migration
GO:0006783  heme biosynthetic process
GO:0060253  negative regulation of glial cell proliferation
GO:0045019  negative regulation of nitric oxide biosynthetic process
GO:0032720  negative regulation of tumor necrosis factor production
GO:0043065  positive regulation of apoptosis
GO:0051928  positive regulation of calcium ion transport
GO:0060252  positive regulation of glial cell proliferation
GO:0051901  positive regulation of mitochondrial depolarization
GO:0010940  positive regulation of necrotic cell death
GO:0006626  protein targeting to mitochondrion
GO:0032374  regulation of cholesterol transport
GO:0050810  regulation of steroid biosynthetic process
GO:0042493  response to drug
GO:0010042  response to manganese ion
GO:0032570  response to progesterone stimulus
GO:0033574  response to testosterone stimulus
GO:0010266  response to vitamin B1
GO:0006694  steroid biosynthetic process
GO:0008202  steroid metabolic process

Cellular Component

GO:0016021  integral to membrane
GO:0005741  mitochondrial outer membrane

Molecular Function

GO:0005497  androgen binding
GO:0008503  benzodiazepine receptor activity
GO:0015485  cholesterol binding