toll-like receptor 4

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Synonym

hToll, TOLL, CD284 antigen, CD284, toll-like receptor 4, Toll-like receptor 4 precursor, TLR4

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:39.10 cerebellum:100.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:35.30 artery/aorta:30 vein:66.60 lymphnode:10.10 peripheral blood:72.90 spleen:56.70 thymus:12.90 bone marrow:78.70 adipose:- bone:64 skin:19.20
GeneChip nodata
CAGE cerebrum:3.70 cerebellum:- brain stem:3.77 corpus callosum/glia:3.85 pineal gland:2.94 peripheral nerve:- spine:3.98 retina:- eye:- artery/aorta:3.80 vein:3.93 lymphnode:3.81 peripheral blood:- spleen:5.08 thymus:2.00 bone marrow:- adipose:4.60 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.18 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.99 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:29.10 prostate:11.30 ovary:- testis:13 heart:- muscle:20.10 esophagus:- stomach:- intestine:32.40 colon:17     liver/hepato:42.20        lung:63.50    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip nodata
CAGE uterus:3.15 placenta:3.64 prostate:3.29 ovary:3.14 testis:2.23 heart:4.02 muscle:3.16 esophagus:3.06 stomach:- intestine:2.94 colon:2.84     liver/hepato:3.25    lung:4.13 bladder:3.04 kidney:3.62 pituitary:2.74 thyroid/parathyroid:3.06 adrenal gland:- pancreas:1.98 breast:4.49 salivary:2.22
RNA-seq uterus:- placenta:- prostate:0.60 ovary:1.39 testis:1.18 heart:0.29 muscle:0.91 esophagus:- stomach:- intestine:- colon:0.55     liver/hepato:1.54        lung:1.20    bladder:- kidney:2.05 pituitary:- thyroid/parathyroid:0.88 adrenal gland:3.20 pancreas:- breast:2.60 salivary:-

IDs

Refseq ID NR_024169
Gene ID 7099
Unigene ID Hs.174312
Probe set ID -
Ensembl ID -
GTEx ID -

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

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23455503
23455702
23457721
23460645
23465595
23467413
23470644
23497941
23504385
23510418
23525077
23526294
23554896
23555011
23565226
23574398
23589304
23592020
23592986
23611610
23612767
23612802
23629657
23633568
23639307
23651260
23665674
23671673
23673286
23677465
23678609
23680697
23690937
23691015
23692033
23706953
23727604
23738004
23747880
23752129
23755898
23761639
23766695
23786414
23798430
23799413
23802631
23810712
23817504
23821954
23828139
23830211
23836485
23853092
23855294
23864765
23867959
23871732
23879541
23880187
23888080
23888605
23908180
23910802
23921128
23929584
23936050
23936790
23949880
23954950
23962979
23971939
23980810
23985798
24007538
24021278
24030146
24043886
24044965
24068665
24076166
24080332
24084649
24085443
24093105
24106112
24108365
24141797
24151602
24165011
24172224
24176535
24178299
24265315
24275652
24277938
24298017
24302816
24307174
24323961
24337704
24405592
24409064
24446182
24493819
24519940
24532584
24567328
24637196
24771848
24783428

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0002322  B cell proliferation during immune response
GO:0071222  cellular response to lipopolysaccharide
GO:0071223  cellular response to lipoteichoic acid
GO:0071260  cellular response to mechanical stimulus
GO:0042742  defense response to bacterium
GO:0050829  defense response to Gram-negative bacterium
GO:0016046  detection of fungus
GO:0032497  detection of lipopolysaccharide
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0007252  I-kappaB phosphorylation
GO:0006955  immune response
GO:0045087  innate immune response
GO:0032609  interferon-gamma production
GO:0060729  intestinal epithelial structure maintenance
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0042116  macrophage activation
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0032689  negative regulation of interferon-gamma production
GO:0032700  negative regulation of interleukin-17 production
GO:0032707  negative regulation of interleukin-23 production
GO:0032715  negative regulation of interleukin-6 production
GO:0045671  negative regulation of osteoclast differentiation
GO:0032720  negative regulation of tumor necrosis factor production
GO:0030890  positive regulation of B cell proliferation
GO:0032722  positive regulation of chemokine production
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050729  positive regulation of inflammatory response
GO:0032727  positive regulation of interferon-alpha production
GO:0045359  positive regulation of interferon-beta biosynthetic process
GO:0032728  positive regulation of interferon-beta production
GO:0032729  positive regulation of interferon-gamma production
GO:0032732  positive regulation of interleukin-1 production
GO:0032733  positive regulation of interleukin-10 production
GO:0045084  positive regulation of interleukin-12 biosynthetic process
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0045416  positive regulation of interleukin-8 biosynthetic process
GO:0032757  positive regulation of interleukin-8 production
GO:0046330  positive regulation of JNK cascade
GO:0060907  positive regulation of macrophage cytokine production
GO:0045348  positive regulation of MHC class II biosynthetic process
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0070430  positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0010572  positive regulation of platelet activation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042535  positive regulation of tumor necrosis factor biosynthetic process
GO:0032760  positive regulation of tumor necrosis factor production
GO:0002537  production of nitric oxide during acute inflammatory response
GO:0050707  regulation of cytokine secretion
GO:0032496  response to lipopolysaccharide
GO:0042088  T-helper 1 type immune response
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0010008  endosome membrane
GO:0009897  external side of plasma membrane
GO:0005887  integral to plasma membrane
GO:0046696  lipopolysaccharide receptor complex
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0001530  lipopolysaccharide binding
GO:0001875  lipopolysaccharide receptor activity
GO:0005515  protein binding
GO:0004872  receptor activity
GO:0004888  transmembrane receptor activity