tuberous sclerosis 1

jump to detail

Synonym

Tuberous sclerosis 1 protein, Hamartin, TSC1, LAM, KIAA0243, MGC86987, hamartin, tuberous sclerosis 1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:54.50

cerebellum:50.40

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:105.80

artery/aorta:60

vein:-

lymphnode:40.40

peripheral blood:-

spleen:132.30

thymus:12.90

bone marrow:-

adipose:40.30

bone:38.40

skin:33.60

GeneChip

cerebrum:7.63

cerebellum:7.91

brain stem:7.68

corpus callosum/glia:7.50

pineal gland:-

peripheral nerve:7.25

spine:7.23

retina:-

eye:-

artery/aorta:6.95

vein:6.70

lymphnode:7.02

peripheral blood:-

spleen:7.16

thymus:7.20

bone marrow:6.81

adipose:6.77

bone:-

skin:7.12

CAGE

cerebrum:3.69

cerebellum:-

brain stem:3.74

corpus callosum/glia:4.05

pineal gland:3.56

peripheral nerve:-

spine:3.30

retina:-

eye:-

artery/aorta:3.01

vein:3.01

lymphnode:2.92

peripheral blood:-

spleen:3.24

thymus:3.15

bone marrow:-

adipose:3.30

bone:-

skin:-

RNA-seq

cerebrum:1.08

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.01

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.20

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:14.60

prostate:67.60

ovary:-

testis:47.60

heart:51.10

muscle:40.20

esophagus:-

stomach:42.50

intestine:32.40

colon:17

liver/hepato:21.10

lung:44

bladder:125.60

kidney:104

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:120.80

salivary:-

GeneChip

uterus:7.26

placenta:6.79

prostate:7.36

ovary:7.58

testis:6.79

heart:7.12

muscle:7.64

esophagus:6.77

stomach:6.89

intestine:6.83

colon:6.29

liver/hepato:6.82

lung:7.15

bladder:-

kidney:7.17

pituitary:7.49

thyroid/parathyroid:7.45

adrenal gland:7.40

pancreas:5.87

breast:7.19

salivary:6.83

CAGE

uterus:3.48

placenta:3.45

prostate:3.30

ovary:3.08

testis:3.78

heart:3.04

muscle:2.97

esophagus:3.05

stomach:-

intestine:3.06

colon:3.17

liver/hepato:2.52

lung:2.98

bladder:3.04

kidney:3.15

pituitary:3.78

thyroid/parathyroid:3.12

adrenal gland:-

pancreas:3.02

breast:2.59

salivary:3.24

RNA-seq

uterus:-

placenta:-

prostate:2.10

ovary:0.55

testis:2.23

heart:0.99

muscle:0.08

esophagus:-

stomach:-

intestine:-

colon:1.19

liver/hepato:0.38

lung:0.65

bladder:-

kidney:1.37

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:0.45

pancreas:-

breast:2.14

salivary:-

IDs

Refseq ID	NM_001162426
Gene ID	7248
Unigene ID	Hs.370854
Probe set ID	209390_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000165699
GTEx ID	ENSG00000165699

Orthologous Gene

Mouse[2]	NM_022887
Rat[1]	NM_021854

Chromosomal Region

9q34.13 [135,766,735 - 135,820,020]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0032862	activation of Rho GTPase activity
GO:0055007	cardiac muscle cell differentiation
GO:0007050	cell cycle arrest
GO:0030030	cell projection organization
GO:0007160	cell-matrix adhesion
GO:0021987	cerebral cortex development
GO:0021766	hippocampus development
GO:0008286	insulin receptor signaling pathway
GO:0001822	kidney development
GO:0042552	myelination
GO:0008285	negative regulation of cell proliferation
GO:0045792	negative regulation of cell size
GO:0032007	negative regulation of TOR signaling pathway
GO:0017148	negative regulation of translation
GO:0001843	neural tube closure
GO:0051894	positive regulation of focal adhesion formation
GO:0006813	potassium ion transport
GO:0051291	protein heterooligomerization
GO:0050821	protein stabilization
GO:0001952	regulation of cell-matrix adhesion
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0045859	regulation of protein kinase activity
GO:0051492	regulation of stress fiber formation
GO:0006417	regulation of translation
GO:0032868	response to insulin stimulus
GO:0006407	rRNA export from nucleus
GO:0050808	synapse organization

Cellular Component

GO:0005884	actin filament
GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030426	growth cone
GO:0043231	intracellular membrane-bounded organelle
GO:0030027	lamellipodium
GO:0016020	membrane
GO:0043234	protein complex
GO:0033596	TSC1-TSC2 complex

Molecular Function

GO:0051087	chaperone binding
GO:0032794	GTPase activating protein binding
GO:0030695	GTPase regulator activity
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

tuberous sclerosis 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function