ubiquitin-conjugating enzyme E2B (RAD6 homolog)

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Synonym

hHR6B, RAD6B, Ubiquitin-conjugating enzyme E2 B, HR6B, Ubiquitin carrier protein B, E2-17kDa, UBE2B, UBC2, E2-17 kDa, Ubiquitin-protein ligase B, ubiquitin-conjugating enzyme E2B (RAD6 homolog), HHR6B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.99 cerebellum:8.05 brain stem:7.89 corpus callosum/glia:7.58 pineal gland:- peripheral nerve:8.06 spine:7.70 retina:- eye:- artery/aorta:8.16 vein:8.48 lymphnode:8.22 peripheral blood:- spleen:8.75 thymus:8.82 bone marrow:8.64 adipose:8.15 bone:- skin:8.35
CAGE cerebrum:3.96 cerebellum:- brain stem:3.53 corpus callosum/glia:3.12 pineal gland:4.33 peripheral nerve:- spine:3.84 retina:- eye:- artery/aorta:4.24 vein:3.71 lymphnode:3.66 peripheral blood:- spleen:3.27 thymus:3.46 bone marrow:- adipose:3.66 bone:- skin:-
RNA-seq cerebrum:4.57 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.14 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.61 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:8.31 placenta:9.02 prostate:8.57 ovary:8.43 testis:8.61 heart:9.14 muscle:9.46 esophagus:8.48 stomach:8.31 intestine:8.56 colon:7.94 liver/hepato:8.13 lung:8.65 bladder:- kidney:8.22 pituitary:8.11 thyroid/parathyroid:8.53 adrenal gland:9.01 pancreas:8.46 breast:8.36 salivary:8.26
CAGE uterus:3.68 placenta:4.20 prostate:3.76 ovary:3.57 testis:4.04 heart:4.78 muscle:5.47 esophagus:3.79 stomach:- intestine:3.69 colon:3.93     liver/hepato:3.42    lung:4.10 bladder:3.98 kidney:3.44 pituitary:3.97 thyroid/parathyroid:3.81 adrenal gland:- pancreas:4.07 breast:4.13 salivary:3.41
RNA-seq uterus:- placenta:- prostate:5.39 ovary:4.60 testis:5.22 heart:5.34 muscle:5.92 esophagus:- stomach:- intestine:- colon:5.45     liver/hepato:3.96        lung:5.59    bladder:- kidney:4.95 pituitary:- thyroid/parathyroid:5.26 adrenal gland:4.10 pancreas:- breast:5.03 salivary:-

Gene Information

IDs

Refseq ID NM_003337
Gene ID 7320
Unigene ID Hs.644421
Probe set ID 202333_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000119048
GTEx ID ENSG00000119048

Orthologous Gene

Mouse[2]  NM_009458
Rat [0]  

Chromosomal Region

5q31.1  [133,706,870  -  133,727,683]

Gene Family (Interpro ID)

IPR000608  Ubiquitin-conjugating enzyme, E2
IPR016135  Ubiquitin-conjugating enzyme/RWD-like

Link to Pubmed  (Pubmed ID)

1559696
1717990
1883845
2158443
8575614
10373550
10884424
10908344
11714696
11885984
11929833
12477932
12524449
12776193
14585983
14981545
15001359
15359278
15489334
16169070
16344560
16595681
16824193
17050667
17597759
17720710
18245774
18339854
18363965
18385908
18497339
18854154
19123975
19410543
19466589
19548583
19549727
20064529
20080676
20378615
20675655
21041297
21113135
21139048
21422291
21443952
21549715
21816346
21858012
21884979
21963094
21965653
22069333
22083959
22547805
22705350
22939629
23079972
23378580
23525009
24681954

Gene Ontology  (GO ID)

Biological Process

GO:0032869  cellular response to insulin stimulus
GO:0051026  chiasma formation
GO:0006281  DNA repair
GO:0033522  histone H2A ubiquitination
GO:0070076  histone lysine demethylation
GO:0001701  in utero embryonic development
GO:0006344  maintenance of chromatin silencing
GO:0043066  negative regulation of apoptosis
GO:0043951  negative regulation of cAMP-mediated signaling
GO:0033128  negative regulation of histone phosphorylation
GO:0010845  positive regulation of reciprocal meiotic recombination
GO:0006301  postreplication repair
GO:0043161  proteasomal ubiquitin-dependent protein catabolic process
GO:0051865  protein autoubiquitination
GO:0070979  protein K11-linked ubiquitination
GO:0070936  protein K48-linked ubiquitination
GO:0070534  protein K63-linked ubiquitination
GO:0006513  protein monoubiquitination
GO:0000209  protein polyubiquitination
GO:0050821  protein stabilization
GO:0016567  protein ubiquitination
GO:0006974  response to DNA damage stimulus
GO:0042493  response to drug
GO:0001666  response to hypoxia
GO:0009411  response to UV
GO:0007288  sperm axoneme assembly
GO:0007283  spermatogenesis
GO:0070193  synaptonemal complex organization
GO:0006511  ubiquitin-dependent protein catabolic process
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0000785  chromatin
GO:0005737  cytoplasm
GO:0033503  HULC complex
GO:0000790  nuclear chromatin
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0005657  replication fork
GO:0001741  XY body

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0031625  ubiquitin protein ligase binding
GO:0004842  ubiquitin-protein ligase activity