nuclear receptor subfamily 1, group H, member 2

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Synonym

nuclear receptor subfamily 1, group H, member 2, NER, RIP15, Oxysterols receptor LXR-beta, NER-I, LXRB, Nuclear receptor NER, Nuclear orphan receptor LXR-beta, NR1H2, Liver X receptor beta, LXR-b, Ubiquitously-expressed nuclear receptor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:157.60 cerebellum:201.50 brain stem:- corpus callosum/glia:262.50 pineal gland:- peripheral nerve:153.40 spine:- retina:- eye:182.20 artery/aorta:179.90 vein:- lymphnode:343.80 peripheral blood:419 spleen:264.70 thymus:180.40 bone marrow:295.20 adipose:242 bone:345.50 skin:105.60
GeneChip cerebrum:6.81 cerebellum:6.74 brain stem:6.84 corpus callosum/glia:6.93 pineal gland:- peripheral nerve:6.62 spine:6.63 retina:- eye:- artery/aorta:7.18 vein:7.10 lymphnode:6.90 peripheral blood:- spleen:7 thymus:6.49 bone marrow:6.69 adipose:6.97 bone:- skin:6.67
CAGE cerebrum:3.93 cerebellum:- brain stem:4.08 corpus callosum/glia:3.94 pineal gland:4.16 peripheral nerve:- spine:4.18 retina:- eye:- artery/aorta:4.22 vein:4.03 lymphnode:3.75 peripheral blood:- spleen:3.87 thymus:3.63 bone marrow:- adipose:3.83 bone:- skin:-
RNA-seq cerebrum:3.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.08 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.65 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:173.20 placenta:178.50 prostate:225.30 ovary:74.50 testis:108.20 heart:89.40 muscle:140.60 esophagus:- stomach:191.20 intestine:324 colon:76.30     liver/hepato:84.40        lung:127.10    bladder:376.80 kidney:114.40 pituitary:- thyroid/parathyroid:1310 adrenal gland:50.80 pancreas:53.30 breast:158 salivary:328.40
GeneChip uterus:6.68 placenta:6.48 prostate:6.70 ovary:6.66 testis:6.85 heart:6.99 muscle:7.16 esophagus:7.13 stomach:6.78 intestine:6.74 colon:7 liver/hepato:6.80 lung:7.23 bladder:- kidney:7.03 pituitary:6.40 thyroid/parathyroid:7.05 adrenal gland:7.12 pancreas:6.53 breast:6.95 salivary:6.80
CAGE uterus:3.94 placenta:4.09 prostate:4.05 ovary:3.93 testis:4.02 heart:4.16 muscle:4.38 esophagus:4.10 stomach:- intestine:4.08 colon:3.71     liver/hepato:4.03    lung:4.07 bladder:4.11 kidney:4.02 pituitary:3.55 thyroid/parathyroid:3.99 adrenal gland:- pancreas:3.89 breast:3.56 salivary:3.90
RNA-seq uterus:- placenta:- prostate:4.80 ovary:4.04 testis:4.41 heart:3.57 muscle:4.57 esophagus:- stomach:- intestine:- colon:4.37     liver/hepato:3.18        lung:4.93    bladder:- kidney:3.83 pituitary:- thyroid/parathyroid:4.86 adrenal gland:4.58 pancreas:- breast:3.92 salivary:-

Gene Information

IDs

Refseq ID NM_007121
Gene ID 7376
Unigene ID Hs.432976
Probe set ID 218215_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000131408
GTEx ID ENSG00000131408

Orthologous Gene

Mouse[1]  NM_009473
Rat [0]  

Chromosomal Region

19q13.33  [50,832,949  -  50,886,266]

Gene Family (Interpro ID)

IPR003069  Ecdysteroid receptor
IPR003078  Retinoic acid receptor
IPR001723  Steroid hormone receptor
IPR001728  Thyroid hormone receptor
IPR013088  Zinc finger, NHR/GATA-type
IPR001628  Zinc finger, nuclear hormone receptor-type

Link to Pubmed  (Pubmed ID)

7625741
7760852
7782080
7926814
7971966
9013544
9874807
10187832
11158331
11546778
12040022
12198243
12393874
12477932
12663743
12724417
12736258
12819202
12957674
14643652
14699103
14702039
15489334
15539633
15548517
15604093
15774904
16141411
16189514
16219912
16298468
16344560
16354658
16482468
16524875
16567856
16904112
16973760
17045963
17108812
17110595
17135302
17186944
17218271
17391100
17396233
17405904
17626048
17693624
17724434
17766241
17845217
17900622
17936707
18026184
18081155
18182682
18221307
18372238
18597895
18636124
18660489
18782758
18854425
19060904
19105208
19242521
19292929
19303409
19426978
19436111
19481530
19796621
19837721
19913121
19933273
19948975
20159957
20176747
20219900
20364260
20628086
20655109
20836841
20855565
20939869
21042792
21315073
21331046
21356276
21507939
21900206
21937108
21951066
21988832
22027013
22029530
22257474
22367754
22610535
22723445
22766509
22939629
22969086
22990668
23018104
23223141
23455924
23686114
23838803
23867501
23987069
24100084
24398515
24561505

Gene Ontology  (GO ID)

Biological Process

GO:0044255  cellular lipid metabolic process
GO:0042632  cholesterol homeostasis
GO:0010467  gene expression
GO:0010887  negative regulation of cholesterol storage
GO:0060336  negative regulation of interferon-gamma-mediated signaling pathway
GO:0032369  negative regulation of lipid transport
GO:0010745  negative regulation of macrophage derived foam cell differentiation
GO:0048550  negative regulation of pinocytosis
GO:0045861  negative regulation of proteolysis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0032270  positive regulation of cellular protein metabolic process
GO:0010875  positive regulation of cholesterol efflux
GO:0032376  positive regulation of cholesterol transport
GO:0045723  positive regulation of fatty acid biosynthetic process
GO:0090108  positive regulation of high-density lipoprotein particle assembly
GO:0010884  positive regulation of lipid storage
GO:0051006  positive regulation of lipoprotein lipase activity
GO:0090187  positive regulation of pancreatic juice secretion
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0010867  positive regulation of triglyceride biosynthetic process
GO:0048384  retinoic acid receptor signaling pathway
GO:0006367  transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0003677  DNA binding
GO:0004879  ligand-dependent nuclear receptor activity
GO:0005515  protein binding
GO:0046965  retinoid X receptor binding
GO:0043565  sequence-specific DNA binding
GO:0003707  steroid hormone receptor activity
GO:0008270  zinc ion binding