Wolfram syndrome 1 (wolframin)

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Synonym

DFNA14, DIDMOAD, WFRS, WOLFRAMIN, Wolfram syndrome 1 (wolframin), Wolframin, DFNA6, WFS1, DFNA38, WFS

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:7.20

cerebellum:6.76

brain stem:7.23

corpus callosum/glia:7

pineal gland:-

peripheral nerve:7.63

spine:7.42

retina:-

eye:-

artery/aorta:8.19

vein:7.70

lymphnode:6.65

peripheral blood:-

spleen:7.41

thymus:5.97

bone marrow:5.52

adipose:7.32

bone:-

skin:6.96

CAGE

cerebrum:4.26

cerebellum:-

brain stem:3.93

corpus callosum/glia:4.01

pineal gland:3.18

peripheral nerve:-

spine:4.20

retina:-

eye:-

artery/aorta:4.79

vein:3.74

lymphnode:3.04

peripheral blood:-

spleen:3.48

thymus:2.03

bone marrow:-

adipose:4.14

bone:-

skin:-

RNA-seq

cerebrum:3.43

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.61

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.10

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:7.74

placenta:6.92

prostate:7.49

ovary:7.73

testis:7.94

heart:7.35

muscle:5.93

esophagus:6.35

stomach:7.14

intestine:6.84

colon:6.72

liver/hepato:6.30

lung:7.89

bladder:-

kidney:6.57

pituitary:8.32

thyroid/parathyroid:8.03

adrenal gland:7.07

pancreas:7

breast:7.39

salivary:6.45

CAGE

uterus:4.46

placenta:4.52

prostate:4.20

ovary:4.88

testis:4.46

heart:4.23

muscle:3.10

esophagus:3.59

stomach:-

intestine:3.34

colon:3.59

liver/hepato:3.32

lung:4.43

bladder:4.57

kidney:3.02

pituitary:4.32

thyroid/parathyroid:4.27

adrenal gland:-

pancreas:3.57

breast:4.24

salivary:3.24

RNA-seq

uterus:-

placenta:-

prostate:1.72

ovary:4.19

testis:1.61

heart:1.17

muscle:2.60

esophagus:-

stomach:-

intestine:-

colon:0.42

liver/hepato:0.03

lung:3.03

bladder:-

kidney:2.59

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:1.29

pancreas:-

breast:1.49

salivary:-

IDs

Refseq ID	NM_001145853
Gene ID	7466
Unigene ID	-
Probe set ID	202908_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000109501
GTEx ID	ENSG00000109501

Orthologous Gene

Mouse[1]	NM_011716
Rat[1]	NM_031823

Chromosomal Region

4p16.1 [6,271,576 - 6,304,992]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0055074	calcium ion homeostasis
GO:0044267	cellular protein metabolic process
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0006983	ER overload response
GO:0030433	ER-associated protein catabolic process
GO:0042593	glucose homeostasis
GO:0001822	kidney development
GO:0043524	negative regulation of neuron apoptosis
GO:0043069	negative regulation of programmed cell death
GO:0043433	negative regulation of transcription factor activity
GO:0050877	neurological system process
GO:0070845	polyubiquitinated misfolded protein transport
GO:0051928	positive regulation of calcium ion transport
GO:0045927	positive regulation of growth
GO:0051247	positive regulation of protein metabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0045862	positive regulation of proteolysis
GO:0022417	protein maturation by protein folding
GO:0050821	protein stabilization
GO:0003091	renal water homeostasis
GO:0034976	response to endoplasmic reticulum stress
GO:0007605	sensory perception of sound
GO:0007601	visual perception

Cellular Component

GO:0030425	dendrite
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral to endoplasmic reticulum membrane

Molecular Function

GO:0051117	ATPase binding
GO:0033613	transcription activator binding
GO:0005215	transporter activity
GO:0031625	ubiquitin protein ligase binding

Wolfram syndrome 1 (wolframin)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function