zona pellucida glycoprotein 3 (sperm receptor)

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Synonym

ZPC, ZP3A/ZP3B, ZP3-474, zona pellucida glycoprotein 3A (sperm receptor), ZP3-424, ZP3-372, ZP3, Zona pellucida protein C, ZP3B, Sperm receptor, zona pellucida glycoprotein 3 (sperm receptor), HUMZP3, Zona pellucida sperm-binding protein 3 precursor, ZP3A, Zona pellucida glycoprotein ZP3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.02 cerebellum:5.53 brain stem:4.79 corpus callosum/glia:4.85 pineal gland:- peripheral nerve:4.92 spine:4.96 retina:- eye:- artery/aorta:5.21 vein:5.08 lymphnode:4.97 peripheral blood:- spleen:4.66 thymus:4.40 bone marrow:4.67 adipose:5.47 bone:- skin:5.26
CAGE cerebrum:1.04 cerebellum:- brain stem:1.16 corpus callosum/glia:1.08 pineal gland:1.53 peripheral nerve:- spine:0.85 retina:- eye:- artery/aorta:0.47 vein:1.03 lymphnode:1.40 peripheral blood:- spleen:1.12 thymus:0.42 bone marrow:- adipose:0.90 bone:- skin:-
RNA-seq cerebrum:1.72 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.60 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.20 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.98 placenta:4.39 prostate:5.04 ovary:4.89 testis:6.95 heart:4.96 muscle:4.78 esophagus:5.09 stomach:4.97 intestine:5.13 colon:5.27 liver/hepato:4.28 lung:4.67 bladder:- kidney:5.26 pituitary:4.95 thyroid/parathyroid:4.91 adrenal gland:4.81 pancreas:4.33 breast:5.52 salivary:5.12
CAGE uterus:1.04 placenta:0.54 prostate:0.66 ovary:0.92 testis:0.74 heart:0.41 muscle:0.09 esophagus:1.46 stomach:- intestine:0.96 colon:0.96     liver/hepato:0.26    lung:0.31 bladder:0.26 kidney:0.67 pituitary:1.22 thyroid/parathyroid:0.64 adrenal gland:- pancreas:1.98 breast:0.55 salivary:0.62
RNA-seq uterus:- placenta:- prostate:1.40 ovary:1.59 testis:1.80 heart:0.33 muscle:1.62 esophagus:- stomach:- intestine:- colon:1.38     liver/hepato:0.33        lung:0.70    bladder:- kidney:0.58 pituitary:- thyroid/parathyroid:1.49 adrenal gland:2.57 pancreas:- breast:3.57 salivary:-

Gene Information

IDs

Refseq ID NM_001110354
Gene ID 7784
Unigene ID -
Probe set ID 210910_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000188372
GTEx ID ENSG00000188372

Orthologous Gene

Mouse[1]  NM_011776
Rat [0]  

Chromosomal Region

7q11.23  [76,026,835  -  76,071,388]

Gene Family (Interpro ID)

IPR001507  Endoglin/CD105 antigen
IPR017976  Endoglin/CD105 antigen subgroup

Link to Pubmed  (Pubmed ID)

1478648
2385582
7789967
8269854
8467708
8984187
9609824
10099990
10864856
11739644
11751269
11804956
11854410
11940668
12035074
12477932
14673092
14702039
15379548
15950651
16344560
16407501
17192598
18033806
18502569
18667750
19004505
19246320
19700799
19945174
20237496
21906983
22889493
24163370
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0007339  binding of sperm to zona pellucida
GO:0001825  blastocyst formation
GO:0002455  humoral immune response mediated by circulating immunoglobulin
GO:0006886  intracellular protein transport
GO:0071421  manganese ion transmembrane transport
GO:0006828  manganese ion transport
GO:0032504  multicellular organism reproduction
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0048599  oocyte development
GO:0048015  phosphoinositide-mediated signaling
GO:0002922  positive regulation of humoral immune response
GO:0050729  positive regulation of inflammatory response
GO:0032729  positive regulation of interferon-gamma production
GO:0032753  positive regulation of interleukin-4 production
GO:0002687  positive regulation of leukocyte migration
GO:0010513  positive regulation of phosphatidylinositol biosynthetic process
GO:0045860  positive regulation of protein kinase activity
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0042102  positive regulation of T cell proliferation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0001809  positive regulation of type IV hypersensitivity
GO:0070528  protein kinase C signaling cascade
GO:0007338  single fertilization

Cellular Component

GO:0001669  acrosomal vesicle
GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0005771  multivesicular body
GO:0002081  outer acrosomal membrane
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0005578  proteinaceous extracellular matrix
GO:0030141  secretory granule

Molecular Function

GO:0032190  acrosin binding
GO:0030246  carbohydrate binding
GO:0005384  manganese ion transmembrane transporter activity
GO:0005515  protein binding
GO:0004871  signal transducer activity
GO:0015279  store-operated calcium channel activity