mitogen-activated protein kinase-activated protein kinase 3

 jump to detail

Synonym

MAPKAP kinase 3, MAPKAPK3, MAP kinase-activated protein kinase 3, Chromosome 3p kinase, MAPKAPK-3, MAPK-activated protein kinase 3, 3PK, MAPKAP3, 3pK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:70.50 artery/aorta:- vein:- lymphnode:60.70 peripheral blood:54.70 spleen:- thymus:25.80 bone marrow:511.70 adipose:- bone:- skin:148.80
GeneChip cerebrum:6.58 cerebellum:6.26 brain stem:6.72 corpus callosum/glia:6.87 pineal gland:- peripheral nerve:6.35 spine:6.93 retina:- eye:- artery/aorta:7.21 vein:7.39 lymphnode:7.30 peripheral blood:- spleen:7.20 thymus:7.39 bone marrow:8.32 adipose:7.12 bone:- skin:7.98
CAGE cerebrum:2.62 cerebellum:- brain stem:2.97 corpus callosum/glia:3.20 pineal gland:2.80 peripheral nerve:- spine:3.13 retina:- eye:- artery/aorta:2.84 vein:3.50 lymphnode:3.84 peripheral blood:- spleen:3.72 thymus:4.24 bone marrow:- adipose:3.44 bone:- skin:-
RNA-seq cerebrum:2.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.62 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:47.40 prostate:45.10 ovary:111.80 testis:17.30 heart:114.90 muscle:261.20 esophagus:- stomach:21.20 intestine:- colon:17     liver/hepato:-        lung:58.70    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:62.20 breast:27.90 salivary:-
GeneChip uterus:6.57 placenta:6.94 prostate:7.17 ovary:6.80 testis:6.69 heart:9.23 muscle:8.72 esophagus:8.28 stomach:7.14 intestine:7.68 colon:7.41 liver/hepato:7.19 lung:7.36 bladder:- kidney:7.93 pituitary:7.38 thyroid/parathyroid:8.19 adrenal gland:7.63 pancreas:7.97 breast:7.36 salivary:7.32
CAGE uterus:3.03 placenta:3.31 prostate:3.30 ovary:3.38 testis:2.75 heart:4.96 muscle:5.00 esophagus:3.71 stomach:- intestine:3.63 colon:3.38     liver/hepato:3.50    lung:3.85 bladder:2.98 kidney:4.02 pituitary:3.19 thyroid/parathyroid:4.21 adrenal gland:- pancreas:4.27 breast:3.12 salivary:3.76
RNA-seq uterus:- placenta:- prostate:2.60 ovary:2.95 testis:2.06 heart:5.98 muscle:5.46 esophagus:- stomach:- intestine:- colon:1.88     liver/hepato:2.08        lung:3.04    bladder:- kidney:3.99 pituitary:- thyroid/parathyroid:4.95 adrenal gland:3.22 pancreas:- breast:3.09 salivary:-

Gene Information

IDs

Refseq ID NM_004635
Gene ID 7867
Unigene ID Hs.234521
Probe set ID 202788_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000114738
GTEx ID ENSG00000114738

Orthologous Gene

Mouse[1]  NM_178907
Rat [0]  

Chromosomal Region

3p21.2  [50,648,951  -  50,686,720]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8603390
8622688
8626550
8774846
8846784
8943323
9207191
9297626
10781029
11157753
11520933
11975836
12171600
12477932
15276183
15302577
15489334
15563468
15850461
16341674
17207965
17894482
19208361
19367581
19913121
19937655
19953087
20628086
21832049
21900206
21988832
22087225
22505724
23000965
23127979
23455922
23487458
23602568
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0045087  innate immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0018105  peptidyl-serine phosphorylation
GO:0007265  Ras protein signal transduction
GO:0032496  response to lipopolysaccharide
GO:0006950  response to stress
GO:0007165  signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0004708  MAP kinase kinase activity
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity