carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

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Synonym

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Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.90 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:92 spine:- retina:- eye:58.80 artery/aorta:- vein:266.60 lymphnode:60.70 peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:76.80 skin:62.40
GeneChip cerebrum:5.93 cerebellum:5.76 brain stem:6 corpus callosum/glia:5.97 pineal gland:- peripheral nerve:6.11 spine:6.07 retina:- eye:- artery/aorta:6.28 vein:5.87 lymphnode:6.41 peripheral blood:- spleen:6.08 thymus:6.29 bone marrow:6.45 adipose:6.30 bone:- skin:6.38
CAGE cerebrum:2.65 cerebellum:- brain stem:2.62 corpus callosum/glia:2.59 pineal gland:2.67 peripheral nerve:- spine:2.91 retina:- eye:- artery/aorta:2.68 vein:2.95 lymphnode:3.23 peripheral blood:- spleen:3.05 thymus:3.50 bone marrow:- adipose:2.64 bone:- skin:-
RNA-seq cerebrum:1.12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.35 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.77 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:7.30 prostate:- ovary:37.30 testis:30.30 heart:51.10 muscle:- esophagus:- stomach:- intestine:- colon:67.80     liver/hepato:21.10        lung:29.30    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:65.10 salivary:-
GeneChip uterus:6.46 placenta:6.04 prostate:6.01 ovary:6.42 testis:6.83 heart:5.59 muscle:5.61 esophagus:6.16 stomach:6.04 intestine:5.98 colon:6.23 liver/hepato:6 lung:5.81 bladder:- kidney:5.92 pituitary:6.57 thyroid/parathyroid:6.39 adrenal gland:6.17 pancreas:6.09 breast:6.41 salivary:5.81
CAGE uterus:2.99 placenta:2.17 prostate:2.66 ovary:3.33 testis:3.29 heart:2.63 muscle:1.63 esophagus:2.62 stomach:- intestine:2.27 colon:2.84     liver/hepato:3.05    lung:2.68 bladder:2.60 kidney:2.54 pituitary:2.69 thyroid/parathyroid:2.61 adrenal gland:- pancreas:2.81 breast:3.12 salivary:2.43
RNA-seq uterus:- placenta:- prostate:1.95 ovary:3.02 testis:2.36 heart:0.67 muscle:1.19 esophagus:- stomach:- intestine:- colon:1.59     liver/hepato:1.13        lung:1.30    bladder:- kidney:1.94 pituitary:- thyroid/parathyroid:1.88 adrenal gland:2.35 pancreas:- breast:1.72 salivary:-

Gene Information

IDs

Refseq ID NM_004341
Gene ID 790
Unigene ID Hs.377010
Probe set ID 202715_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000084774
GTEx ID ENSG00000084774

Orthologous Gene

Mouse[2]  NM_023525
Rat[1]  NM_001105710

Chromosomal Region

2p23.3  [27,440,258  -  27,466,660]

Gene Family (Interpro ID)

IPR006220  Anthranilate synthase component II/delta crystallin
IPR002082  Aspartate carbamoyltransferase, eukaryotic
IPR006130  Aspartate/ornithine carbamoyltransferase
IPR011761  ATP-grasp fold
IPR001317  Carbamoyl phosphate synthase, GATase domain
IPR000991  Glutamine amidotransferase class-I, C-terminal
IPR011702  Glutamine amidotransferase superfamily
IPR017926  Glutamine amidotransferase type 1
IPR011607  MGS-like

Link to Pubmed  (Pubmed ID)

1979741
2565865
2885743
4092695
8619816
9525610
11854437
11986331
12438317
12477932
12746293
14523024
14559996
15324660
15326225
15489334
15621215
15890648
16051665
16055720
16155188
16196087
16335966
16964243
17081983
17266347
18457437
18679823
18729074
18781797
18854154
19380743
19394292
19596686
19946888
20085233
20379614
20473970
20659789
21081666
21139048
21145461
21319273
21575865
21697133
21890473
21906983
21963094
21982950
21987572
22145905
22268729
22505724
22586326
22623428
22939629
23000965
23125841
23143245
23438482
23455922
23594158
23703321
23752268
24550385
24639526
24654937
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006207  'de novo' pyrimidine base biosynthetic process
GO:0044205  'de novo' UMP biosynthetic process
GO:0070409  carbamoyl phosphate biosynthetic process
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0017144  drug metabolic process
GO:0009790  embryonic development
GO:0007565  female pregnancy
GO:0006543  glutamine catabolic process
GO:0006541  glutamine metabolic process
GO:0007595  lactation
GO:0055086  nucleobase, nucleoside and nucleotide metabolic process
GO:0031100  organ regeneration
GO:0018107  peptidyl-threonine phosphorylation
GO:0046777  protein amino acid autophosphorylation
GO:0006206  pyrimidine base metabolic process
GO:0046134  pyrimidine nucleoside biosynthetic process
GO:0014075  response to amine stimulus
GO:0031000  response to caffeine
GO:0051414  response to cortisol stimulus
GO:0033574  response to testosterone stimulus
GO:0006228  UTP biosynthetic process

Cellular Component

GO:0042995  cell projection
GO:0043025  cell soma
GO:0005829  cytosol
GO:0016363  nuclear matrix
GO:0005634  nucleus
GO:0043234  protein complex
GO:0043195  terminal button

Molecular Function

GO:0070335  aspartate binding
GO:0004070  aspartate carbamoyltransferase activity
GO:0005524  ATP binding
GO:0004088  carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151  dihydroorotase activity
GO:0019899  enzyme binding
GO:0042802  identical protein binding
GO:0046872  metal ion binding
GO:0004672  protein kinase activity