tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

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Synonym

TNKS2, Tankyrase-like protein, PARP-5b, PARP5B, PARP5C, PARP-5c, Tankyrase-related protein, TNKS-2, Tankyrase-2, TANK2, Tankyrase II, TNKL

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:43.90 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:224.60 retina:- eye:41.10 artery/aorta:- vein:- lymphnode:70.80 peripheral blood:18.20 spleen:37.80 thymus:64.40 bone marrow:- adipose:40.30 bone:- skin:48
GeneChip cerebrum:7.03 cerebellum:7.27 brain stem:6.96 corpus callosum/glia:7.40 pineal gland:- peripheral nerve:7.04 spine:7.29 retina:- eye:- artery/aorta:6.99 vein:7.08 lymphnode:7.21 peripheral blood:- spleen:7.78 thymus:8.22 bone marrow:6.87 adipose:6.82 bone:- skin:7.42
CAGE cerebrum:3.56 cerebellum:- brain stem:3.48 corpus callosum/glia:3.58 pineal gland:3.51 peripheral nerve:- spine:3.50 retina:- eye:- artery/aorta:3.59 vein:3.71 lymphnode:3.76 peripheral blood:- spleen:3.75 thymus:4.20 bone marrow:- adipose:3.28 bone:- skin:-
RNA-seq cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.77 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.57 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:120.20 prostate:101.40 ovary:37.30 testis:43.30 heart:12.80 muscle:20.10 esophagus:- stomach:- intestine:- colon:42.40     liver/hepato:73.90        lung:58.70    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:17.80 breast:55.80 salivary:-
GeneChip uterus:7.43 placenta:8.90 prostate:7.51 ovary:7.61 testis:6.27 heart:6.62 muscle:7.92 esophagus:7.65 stomach:6.92 intestine:7.21 colon:6.26 liver/hepato:6.71 lung:7.54 bladder:- kidney:6.65 pituitary:7.49 thyroid/parathyroid:7.38 adrenal gland:7.07 pancreas:6.48 breast:7.53 salivary:6.66
CAGE uterus:3.61 placenta:4.40 prostate:3.46 ovary:3.60 testis:3.08 heart:3.23 muscle:3.78 esophagus:3.63 stomach:- intestine:3.38 colon:3.37     liver/hepato:3.11    lung:3.69 bladder:3.53 kidney:3.14 pituitary:3.78 thyroid/parathyroid:3.55 adrenal gland:- pancreas:3.13 breast:3.49 salivary:3.34
RNA-seq uterus:- placenta:- prostate:3.95 ovary:4.27 testis:3.68 heart:2.66 muscle:3.39 esophagus:- stomach:- intestine:- colon:3.54     liver/hepato:2.74        lung:3.89    bladder:- kidney:3.37 pituitary:- thyroid/parathyroid:4.03 adrenal gland:3.76 pancreas:- breast:3.62 salivary:-

Gene Information

IDs

Refseq ID NM_025235
Gene ID 80351
Unigene ID Hs.329327
Probe set ID 218228_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000107854
GTEx ID ENSG00000107854

Orthologous Gene

Mouse[2]  NM_001163635
Rat[1]  NM_001107607

Chromosomal Region

10q23.32  [93,558,069  -  93,625,033]

Gene Family (Interpro ID)

IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type

Link to Pubmed  (Pubmed ID)

10988299
11205898
11278563
11294570
11454873
11739745
11802774
11854288
12080061
14702039
15164054
15231748
15795250
16151859
16385451
18026951
18393764
19759537
19766477
20237496
20549820
20937264
21048031
21139048
21145461
21799911
21890473
21906983
21963094
22053931
22153076
22153077
22449978
24116873
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0035264  multicellular organism growth
GO:0032212  positive regulation of telomere maintenance via telomerase
GO:0006471  protein amino acid ADP-ribosylation
GO:0070213  protein amino acid auto-ADP-ribosylation
GO:0070198  protein localization to telomere
GO:0000209  protein polyubiquitination
GO:0040014  regulation of multicellular organism growth
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0000139  Golgi membrane
GO:0000784  nuclear chromosome, telomeric region
GO:0005635  nuclear envelope
GO:0005634  nucleus
GO:0000242  pericentriolar material
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0019899  enzyme binding
GO:0046872  metal ion binding
GO:0003950  NAD+ ADP-ribosyltransferase activity
GO:0005515  protein binding