itchy E3 ubiquitin protein ligase homolog (mouse)

Synonym

NAPP1, itchy homolog E3 ubiquitin protein ligase (mouse), dJ468O1.1, Itchy homolog E3 ubiquitin protein ligase, Atrophin-1-interacting protein 4, Itch, NFE2-associated polypeptide 1, AIF4, AIP4, ITCH

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:26.10

cerebellum:37.80

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:29.40

artery/aorta:30

vein:-

lymphnode:50.60

peripheral blood:36.40

spleen:18.90

thymus:103.10

bone marrow:78.70

adipose:-

bone:12.80

skin:124.80

GeneChip

cerebrum:5.99

cerebellum:5.47

brain stem:6.11

corpus callosum/glia:6.39

pineal gland:-

peripheral nerve:5.87

spine:6.18

retina:-

eye:-

artery/aorta:5.68

vein:5.90

lymphnode:5.79

peripheral blood:-

spleen:5.60

thymus:5.97

bone marrow:6.13

adipose:5.83

bone:-

skin:5.76

CAGE

cerebrum:4.26

cerebellum:-

brain stem:4.63

corpus callosum/glia:4.87

pineal gland:4.28

peripheral nerve:-

spine:4.59

retina:-

eye:-

artery/aorta:4.08

vein:4.02

lymphnode:4.11

peripheral blood:-

spleen:4.09

thymus:4.16

bone marrow:-

adipose:4.30

bone:-

skin:-

RNA-seq

cerebrum:4.05

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.68

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.67

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:154.90

placenta:51

prostate:45.10

ovary:37.30

testis:112.50

heart:25.50

muscle:20.10

esophagus:-

stomach:85

intestine:32.40

colon:254.40

liver/hepato:179.40

lung:58.70

bladder:-

kidney:104

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:26.70

breast:158

salivary:-

GeneChip

uterus:5.76

placenta:6.53

prostate:5.76

ovary:5.67

testis:7.84

heart:5.91

muscle:5.74

esophagus:6.91

stomach:5.66

intestine:5.67

colon:5.71

liver/hepato:6.37

lung:5.57

bladder:-

kidney:5.59

pituitary:5.48

thyroid/parathyroid:5.47

adrenal gland:5.61

pancreas:5.62

breast:5.49

salivary:5.69

CAGE

uterus:4.24

placenta:4.43

prostate:3.99

ovary:4.11

testis:4.25

heart:3.85

muscle:3.85

esophagus:4.32

stomach:-

intestine:4.23

colon:3.74

liver/hepato:4.31

lung:4.06

bladder:4.22

kidney:4.15

pituitary:4.40

thyroid/parathyroid:3.99

adrenal gland:-

pancreas:3.73

breast:3.83

salivary:3.78

RNA-seq

uterus:-

placenta:-

prostate:3.64

ovary:3.78

testis:4.01

heart:3.30

muscle:3.59

esophagus:-

stomach:-

intestine:-

colon:3.27

liver/hepato:3.36

lung:3.55

bladder:-

kidney:3.60

pituitary:-

thyroid/parathyroid:3.91

adrenal gland:3.44

pancreas:-

breast:3.69

salivary:-

IDs

Refseq ID	NM_031483
Gene ID	83737
Unigene ID	Hs.632272
Probe set ID	209744_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000078747
GTEx ID	ENSG00000078747

Orthologous Gene

Mouse[1]	NM_008395
Rat [0]

Chromosomal Region

20q11.22 [32,951,041 - 33,099,198]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR001202	WW/Rsp5/WWP

Gene Ontology (GO ID)

Biological Process

GO:0006915	apoptosis
GO:0051607	defense response to virus
GO:0046718	entry of virus into host cell
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0046642	negative regulation of alpha-beta T cell proliferation
GO:0043066	negative regulation of apoptosis
GO:0050687	negative regulation of defense response to virus
GO:0046329	negative regulation of JNK cascade
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0007219	Notch signaling pathway
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0045732	positive regulation of protein catabolic process
GO:0002669	positive regulation of T cell anergy
GO:0070936	protein K48-linked ubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0001558	regulation of cell growth
GO:0090085	regulation of protein deubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0019048	virus-host interaction

Cellular Component

GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0005829	cytosol
GO:0005634	nucleus
GO:0005886	plasma membrane

Molecular Function

GO:0045236	CXCR chemokine receptor binding
GO:0005515	protein binding
GO:0043021	ribonucleoprotein binding
GO:0004842	ubiquitin-protein ligase activity

itchy E3 ubiquitin protein ligase homolog (mouse)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function