caspase 9, apoptosis-related cysteine peptidase

Synonym

CASP-9, ICE-LAP6, Apoptotic protease-activating factor 3, MCH6, caspase 9, apoptosis-related cysteine peptidase, CASP9, APAF3, Caspase-9 precursor, CASPASE-9c, ICE-like apoptotic protease 6, Apoptotic protease Mch-6, APAF-3

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:17.80

cerebellum:75.60

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:35.30

artery/aorta:30

vein:-

lymphnode:20.20

peripheral blood:54.70

spleen:-

thymus:38.70

bone marrow:-

adipose:40.30

bone:38.40

skin:19.20

GeneChip

cerebrum:6.86

cerebellum:6.88

brain stem:6.90

corpus callosum/glia:7.24

pineal gland:-

peripheral nerve:6.63

spine:6.95

retina:-

eye:-

artery/aorta:6.87

vein:6.56

lymphnode:6.82

peripheral blood:-

spleen:6.68

thymus:6.84

bone marrow:6.68

adipose:6.65

bone:-

skin:6.24

CAGE

cerebrum:1.89

cerebellum:-

brain stem:2.14

corpus callosum/glia:2.28

pineal gland:2.33

peripheral nerve:-

spine:2.00

retina:-

eye:-

artery/aorta:2.38

vein:2.03

lymphnode:2.42

peripheral blood:-

spleen:2.34

thymus:1.64

bone marrow:-

adipose:2.05

bone:-

skin:-

RNA-seq

cerebrum:1.56

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.18

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:100.20

placenta:47.40

prostate:22.50

ovary:37.30

testis:38.90

heart:38.30

muscle:-

esophagus:-

stomach:21.20

intestine:-

colon:17

liver/hepato:31.70

lung:9.80

bladder:-

kidney:52

pituitary:116

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:26.70

breast:9.30

salivary:-

GeneChip

uterus:7.04

placenta:6.68

prostate:7.13

ovary:7.57

testis:7.52

heart:6.71

muscle:6.92

esophagus:7.12

stomach:6.76

intestine:6.68

colon:6.74

liver/hepato:6.77

lung:6.90

bladder:-

kidney:7.19

pituitary:7.36

thyroid/parathyroid:7.52

adrenal gland:8.69

pancreas:6.89

breast:6.71

salivary:6.78

CAGE

uterus:1.97

placenta:2.49

prostate:1.95

ovary:3.13

testis:2.47

heart:2.00

muscle:1.17

esophagus:2.00

stomach:-

intestine:2.46

colon:2.04

liver/hepato:1.97

lung:2.41

bladder:1.95

kidney:2.29

pituitary:1.96

thyroid/parathyroid:1.62

adrenal gland:-

pancreas:1.87

breast:1.68

salivary:1.75

RNA-seq

uterus:-

placenta:-

prostate:1.14

ovary:2.74

testis:2.10

heart:0.85

muscle:0.24

esophagus:-

stomach:-

intestine:-

colon:1.45

liver/hepato:0.48

lung:1.34

bladder:-

kidney:1.14

pituitary:-

thyroid/parathyroid:1.97

adrenal gland:1.25

pancreas:-

breast:0.97

salivary:-

IDs

Refseq ID	NM_001229
Gene ID	842
Unigene ID	Hs.329502
Probe set ID	203984_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000132906
GTEx ID	ENSG00000132906

Orthologous Gene

Mouse[4]	NM_015733
Rat[1]	NM_031632

Chromosomal Region

1p36.21 [15,817,327 - 15,853,029]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001315	Caspase Recruitment
IPR017350	Caspase, interleukin-1 beta convertase
IPR011029	DEATH-like
IPR011600	Peptidase C14, caspase catalytic
IPR002398	Peptidase C14, caspase precursor p45
IPR015917	Peptidase C14, caspase precursor p45, core

Gene Ontology (GO ID)

Biological Process

GO:0008635	activation of caspase activity by cytochrome c
GO:0006915	apoptosis
GO:0034644	cellular response to UV
GO:0042770	DNA damage response, signal transduction
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	nerve growth factor receptor signaling pathway
GO:0048015	phosphoinositide-mediated signaling
GO:0043065	positive regulation of apoptosis
GO:0043525	positive regulation of neuron apoptosis
GO:0006508	proteolysis
GO:0042981	regulation of apoptosis
GO:0006974	response to DNA damage stimulus

Cellular Component

GO:0043293	apoptosome
GO:0005829	cytosol
GO:0005634	nucleus

Molecular Function

GO:0004197	cysteine-type endopeptidase activity
GO:0008047	enzyme activator activity
GO:0008233	peptidase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0017124	SH3 domain binding

caspase 9, apoptosis-related cysteine peptidase

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function