serine/threonine kinase 24 (STE20 homolog, yeast)

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Synonym

MST-3, STK3, Serine/threonine-protein kinase 24, MST3B, MST3, STK24, serine/threonine kinase 24 (STE20 homolog, yeast), STE20-like kinase MST3, Mammalian STE20-like protein kinase 3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:75.80 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:148.30 peripheral nerve:92 spine:224.60 retina:118.60 eye:88.20 artery/aorta:89.90 vein:- lymphnode:202.20 peripheral blood:72.90 spleen:94.50 thymus:25.80 bone marrow:118.10 adipose:40.30 bone:12.80 skin:115.20
GeneChip cerebrum:6.73 cerebellum:6.25 brain stem:6.49 corpus callosum/glia:5.92 pineal gland:- peripheral nerve:7.35 spine:6.52 retina:- eye:- artery/aorta:6.94 vein:6.97 lymphnode:7.35 peripheral blood:- spleen:7.36 thymus:7.98 bone marrow:7.58 adipose:7.50 bone:- skin:8.18
CAGE cerebrum:3.64 cerebellum:- brain stem:3.38 corpus callosum/glia:3.64 pineal gland:3.27 peripheral nerve:- spine:3.47 retina:- eye:- artery/aorta:4.31 vein:4.45 lymphnode:4.78 peripheral blood:- spleen:4.54 thymus:4.58 bone marrow:- adipose:4.43 bone:- skin:-
RNA-seq cerebrum:4.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.62 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.54 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:127.50 prostate:56.30 ovary:37.30 testis:82.20 heart:63.90 muscle:- esophagus:342.80 stomach:106.20 intestine:32.40 colon:271.30     liver/hepato:63.30        lung:146.60    bladder:- kidney:145.60 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:115.60 breast:139.40 salivary:-
GeneChip uterus:7.70 placenta:7.89 prostate:7.65 ovary:7.47 testis:7.57 heart:7.02 muscle:6.76 esophagus:9.01 stomach:7.28 intestine:7.45 colon:7.95 liver/hepato:6.12 lung:7.51 bladder:- kidney:7.45 pituitary:6.88 thyroid/parathyroid:7.40 adrenal gland:6.47 pancreas:7.33 breast:7.49 salivary:7.42
CAGE uterus:4.47 placenta:4.68 prostate:4.55 ovary:4.13 testis:4.36 heart:4.31 muscle:3.59 esophagus:4.94 stomach:- intestine:5.27 colon:4.75     liver/hepato:3.53    lung:4.54 bladder:4.80 kidney:4.49 pituitary:3.48 thyroid/parathyroid:4.41 adrenal gland:- pancreas:3.75 breast:4.72 salivary:4.14
RNA-seq uterus:- placenta:- prostate:2.06 ovary:4.47 testis:5.01 heart:1.42 muscle:1.33 esophagus:- stomach:- intestine:- colon:5.01     liver/hepato:1.21        lung:1.37    bladder:- kidney:4.35 pituitary:- thyroid/parathyroid:4.62 adrenal gland:4.17 pancreas:- breast:4.11 salivary:-

Gene Information

IDs

Refseq ID NM_003576
Gene ID 8428
Unigene ID Hs.508514
Probe set ID 208854_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000102572
GTEx ID ENSG00000102572

Orthologous Gene

Mouse[3]  NM_145465
Rat [0]  

Chromosomal Region

13q32.2  [99,102,455  -  99,230,194]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9353338
10644707
11991713
12107159
12477932
15304321
15489334
15917084
16189514
16314523
16344560
17046825
17081983
17081986
17353931
18040775
18654987
18782753
19056867
19240061
19322201
19328558
19604147
19782762
19855390
19953087
20124694
20174665
20379614
20834067
20949042
21277991
21890473
21985334
22159054
22229648
22493453
22505724
22863883
22939629
23000965
23296203
23455922
23722424
23889253
24255178
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0006921  cell structure disassembly during apoptosis
GO:0008631  induction of apoptosis by oxidative stress
GO:0030336  negative regulation of cell migration
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0048679  regulation of axon regeneration
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity