aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

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Synonym

Dihydrodiol dehydrogenase type I, HAKRB, 3-alpha-hydroxysteroid dehydrogenase type 2, hluPGFS, Dihydrodiol dehydrogenase 3, Prostaglandin F synthase, AKR1C3, 17-beta-hydroxysteroid dehydrogenase type 5, DD3, HSD17B5, Estradiol 17-beta-dehydrogenase, DDH1, PGFS, hydroxysteroid (17-beta) dehydrogenase 5, 17-beta-HSD 5, HAKRe, Chlordecone reductase homolog HAKRb, 3-alpha-HSD type II, brain, KIAA0119, Aldo-keto reductase family 1 member C3, 3-alpha-HSD type 2, HA1753, DD-3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:- spine:- retina:- eye:70.50 artery/aorta:119.90 vein:- lymphnode:- peripheral blood:- spleen:18.90 thymus:- bone marrow:196.80 adipose:282.30 bone:89.60 skin:76.80
GeneChip cerebrum:5.31 cerebellum:4.07 brain stem:4.99 corpus callosum/glia:5.60 pineal gland:- peripheral nerve:5.71 spine:6.16 retina:- eye:- artery/aorta:8.32 vein:7.10 lymphnode:5.27 peripheral blood:- spleen:4.16 thymus:7.38 bone marrow:6.28 adipose:9.17 bone:- skin:7.80
CAGE cerebrum:2.34 cerebellum:- brain stem:2.29 corpus callosum/glia:2.71 pineal gland:1.69 peripheral nerve:- spine:2.24 retina:- eye:- artery/aorta:3.42 vein:3.17 lymphnode:2.33 peripheral blood:- spleen:1.24 thymus:2.81 bone marrow:- adipose:5.09 bone:- skin:-
RNA-seq cerebrum:2.42 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.21 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.70 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:18.20 prostate:- ovary:- testis:17.30 heart:- muscle:60.30 esophagus:- stomach:127.50 intestine:324 colon:67.80     liver/hepato:221.70        lung:107.50    bladder:- kidney:239.10 pituitary:116 thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:133.40 breast:83.60 salivary:-
GeneChip uterus:6.57 placenta:4.32 prostate:5.33 ovary:6.50 testis:5.36 heart:6.96 muscle:6.52 esophagus:7.72 stomach:8.39 intestine:8.35 colon:8.58 liver/hepato:8.71 lung:7.54 bladder:- kidney:8.81 pituitary:5.12 thyroid/parathyroid:5.91 adrenal gland:6.56 pancreas:7.34 breast:7.53 salivary:4.65
CAGE uterus:2.88 placenta:1.47 prostate:3.38 ovary:2.92 testis:2.63 heart:3.26 muscle:2.86 esophagus:3.58 stomach:- intestine:5.39 colon:4.74     liver/hepato:5.56    lung:3.83 bladder:3.45 kidney:5.25 pituitary:2.34 thyroid/parathyroid:3.04 adrenal gland:- pancreas:3.20 breast:5.23 salivary:2.17
RNA-seq uterus:- placenta:- prostate:5.14 ovary:4.26 testis:4.82 heart:2.81 muscle:2.91 esophagus:- stomach:- intestine:- colon:4.81     liver/hepato:7.70        lung:5.15    bladder:- kidney:7.01 pituitary:- thyroid/parathyroid:4.88 adrenal gland:4.67 pancreas:- breast:8.29 salivary:-

Gene Information

IDs

Refseq ID NM_003739
Gene ID 8644
Unigene ID Hs.78183
Probe set ID 209160_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000196139
GTEx ID ENSG00000196139

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

10p15.1  [5,077,549  -  5,149,878]

Gene Family (Interpro ID)

IPR001395  Aldo/keto reductase
IPR020471  Aldo/keto reductase subgroup

Link to Pubmed  (Pubmed ID)

7626489
7650035
7788527
7789999
8274401
8718859
8889549
9415401
9792917
9862446
9927279
10393440
10557352
10622721
10672042
10998348
11076863
11165022
11256614
12477932
13678667
14671194
14979715
14996743
14997212
15087468
15164054
15212687
15284179
15489334
15489336
15582534
15781210
15814298
16157291
16169070
16189514
16263811
16302261
16337083
16338060
16381901
16475787
16480815
16601286
16983398
17071532
17149600
17166832
17220347
17507624
17583494
17697149
17940109
18306354
18339682
18508192
18552976
18574251
18632753
18641923
18676680
18692800
18984855
18996480
19007764
19162045
19170196
19273550
19320734
19336370
19336506
19423521
19442656
19460435
19487289
19574343
19625176
19692168
19846565
19942269
20036328
20086173
20126582
20145130
20201926
20379614
20453000
20634197
20661409
20689807
20734064
21039282
21151387
21232532
21323680
21365123
21444150
21521174
21851338
21886157
21963094
22170488
22505408
22670171
23024260
23116553
23165153
23183084
23196782
23519145
23748150
24012099
24228104
24316309
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0019369  arachidonic acid metabolic process
GO:0071276  cellular response to cadmium ion
GO:0071277  cellular response to calcium ion
GO:0071384  cellular response to corticosteroid stimulus
GO:0071395  cellular response to jasmonic acid stimulus
GO:0071379  cellular response to prostaglandin stimulus
GO:0034614  cellular response to reactive oxygen species
GO:0009267  cellular response to starvation
GO:0019371  cyclooxygenase pathway
GO:0016488  farnesol catabolic process
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0030216  keratinocyte differentiation
GO:0008584  male gonad development
GO:0044259  multicellular organismal macromolecule metabolic process
GO:0055114  oxidation reduction
GO:0007603  phototransduction, visible light
GO:0010942  positive regulation of cell death
GO:0008284  positive regulation of cell proliferation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0042448  progesterone metabolic process
GO:0006693  prostaglandin metabolic process
GO:0000060  protein import into nucleus, translocation
GO:0048385  regulation of retinoic acid receptor signaling pathway
GO:0070293  renal absorption
GO:0007584  response to nutrient
GO:0034694  response to prostaglandin stimulus
GO:0042574  retinal metabolic process
GO:0001523  retinoid metabolic process
GO:0008202  steroid metabolic process

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005622  intracellular
GO:0005634  nucleus

Molecular Function

GO:0047020  15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047023  3(or 17)-alpha-hydroxysteroid dehydrogenase activity
GO:0047035  3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
GO:0047026  3-alpha-hydroxysteroid dehydrogenase (A-specific) activity
GO:0004032  aldehyde reductase activity
GO:0004033  aldo-keto reductase activity
GO:0047787  delta4-3-oxosteroid 5beta-reductase activity
GO:0045550  geranylgeranyl reductase activity
GO:0047718  indanol dehydrogenase activity
GO:0045703  ketoreductase activity
GO:0047086  ketosteroid monooxygenase activity
GO:0016655  oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
GO:0018636  phenanthrene 9,10-monooxygenase activity
GO:0004958  prostaglandin F receptor activity
GO:0047017  prostaglandin-F synthase activity
GO:0001758  retinal dehydrogenase activity
GO:0004745  retinol dehydrogenase activity
GO:0047045  testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047115  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity