insulin receptor substrate 2

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Synonym

Insulin receptor substrate 2, insulin receptor substrate 2, IRS2, IRS-2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:27.30

cerebellum:25.20

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:92

spine:-

retina:-

eye:111.70

artery/aorta:-

vein:-

lymphnode:40.40

peripheral blood:91.10

spleen:18.90

thymus:-

bone marrow:98.40

adipose:40.30

bone:38.40

skin:76.80

GeneChip

cerebrum:9.07

cerebellum:9.12

brain stem:8.85

corpus callosum/glia:8.96

pineal gland:-

peripheral nerve:8.98

spine:9

retina:-

eye:-

artery/aorta:8.46

vein:8

lymphnode:7.22

peripheral blood:-

spleen:7.07

thymus:6.75

bone marrow:8.56

adipose:9.13

bone:-

skin:8.56

CAGE

cerebrum:5.05

cerebellum:-

brain stem:4.93

corpus callosum/glia:4.80

pineal gland:4.05

peripheral nerve:-

spine:5.47

retina:-

eye:-

artery/aorta:5.03

vein:4.25

lymphnode:3.68

peripheral blood:-

spleen:3.68

thymus:3.20

bone marrow:-

adipose:5.18

bone:-

skin:-

RNA-seq

cerebrum:4.18

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.76

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.72

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:145.80

placenta:47.40

prostate:78.90

ovary:74.50

testis:34.60

heart:51.10

muscle:40.20

esophagus:-

stomach:-

intestine:32.40

colon:76.30

liver/hepato:327.20

lung:34.20

bladder:-

kidney:10.40

pituitary:347.90

thyroid/parathyroid:-

adrenal gland:-

pancreas:62.20

breast:74.30

salivary:-

GeneChip

uterus:7.93

placenta:9.51

prostate:9.68

ovary:8.98

testis:7.54

heart:8.54

muscle:8.43

esophagus:7.32

stomach:7.74

intestine:7.90

colon:8.03

liver/hepato:8.89

lung:8.56

bladder:-

kidney:7.80

pituitary:9.11

thyroid/parathyroid:7.90

adrenal gland:9.56

pancreas:7.63

breast:8.81

salivary:7.81

CAGE

uterus:4.47

placenta:4.77

prostate:4.47

ovary:4.38

testis:4.07

heart:4.36

muscle:4.59

esophagus:4.22

stomach:-

intestine:3.85

colon:4.20

liver/hepato:4.77

lung:4.64

bladder:4.43

kidney:3.10

pituitary:5.29

thyroid/parathyroid:3.99

adrenal gland:-

pancreas:3.82

breast:5.72

salivary:4.01

RNA-seq

uterus:-

placenta:-

prostate:3.53

ovary:2.49

testis:2.44

heart:3.80

muscle:4.23

esophagus:-

stomach:-

intestine:-

colon:3.79

liver/hepato:2.92

lung:2.55

bladder:-

kidney:1.99

pituitary:-

thyroid/parathyroid:3.76

adrenal gland:1.15

pancreas:-

breast:4.29

salivary:-

IDs

Refseq ID	NM_003749
Gene ID	8660
Unigene ID	Hs.442344
Probe set ID	209185_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000185950
GTEx ID	ENSG00000185950

Orthologous Gene

Mouse[1]	NM_001081212
Rat[3]	NM_001168633

Chromosomal Region

13q34 [110,406,184 - 110,438,915]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001849

Pleckstrin homology

Gene Ontology (GO ID)

Biological Process

GO:0007420	brain development
GO:0008283	cell proliferation
GO:0032869	cellular response to insulin stimulus
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0006006	glucose metabolic process
GO:0045087	innate immune response
GO:0008286	insulin receptor signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0055088	lipid homeostasis
GO:0030879	mammary gland development
GO:0002903	negative regulation of B cell apoptosis
GO:0033673	negative regulation of kinase activity
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
GO:0048011	nerve growth factor receptor signaling pathway
GO:0048015	phosphoinositide-mediated signaling
GO:0030890	positive regulation of B cell proliferation
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0046326	positive regulation of glucose import
GO:0010907	positive regulation of glucose metabolic process
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0032024	positive regulation of insulin secretion
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0019216	regulation of lipid metabolic process
GO:0009749	response to glucose stimulus
GO:0007165	signal transduction

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane

Molecular Function

GO:0005158	insulin receptor binding
GO:0043548	phosphoinositide 3-kinase binding
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0004871	signal transducer activity

insulin receptor substrate 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function