Fas (TNFRSF6)-associated via death domain

Synonym

FADD protein, Mediator of receptor induced toxicity, MORT1, MGC8528, GIG3, Fas (TNFRSF6)-associated via death domain, FADD, FAS-associating death domain-containing protein

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:5.41

cerebellum:5.66

brain stem:5.43

corpus callosum/glia:5.70

pineal gland:-

peripheral nerve:5.81

spine:5.50

retina:-

eye:-

artery/aorta:5.69

vein:5.85

lymphnode:6.02

peripheral blood:-

spleen:6.30

thymus:6.52

bone marrow:6.14

adipose:5.94

bone:-

skin:5.95

CAGE

cerebrum:2.24

cerebellum:-

brain stem:2.28

corpus callosum/glia:2.48

pineal gland:1.72

peripheral nerve:-

spine:2.15

retina:-

eye:-

artery/aorta:2.43

vein:3.08

lymphnode:2.93

peripheral blood:-

spleen:2.77

thymus:3.31

bone marrow:-

adipose:2.80

bone:-

skin:-

RNA-seq

cerebrum:2.53

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.76

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.07

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:6.23

placenta:6.36

prostate:5.89

ovary:6.42

testis:5.65

heart:5.70

muscle:5.63

esophagus:6.34

stomach:5.94

intestine:6.01

colon:6.30

liver/hepato:5.89

lung:5.92

bladder:-

kidney:6.23

pituitary:5.46

thyroid/parathyroid:6.20

adrenal gland:6.16

pancreas:5.88

breast:6.50

salivary:5.98

CAGE

uterus:2.68

placenta:3.18

prostate:2.66

ovary:2.59

testis:2.39

heart:2.30

muscle:1.70

esophagus:2.79

stomach:-

intestine:2.84

colon:2.72

liver/hepato:2.57

lung:2.65

bladder:2.44

kidney:2.87

pituitary:2.13

thyroid/parathyroid:2.79

adrenal gland:-

pancreas:3.10

breast:2.34

salivary:2.57

RNA-seq

uterus:-

placenta:-

prostate:2.98

ovary:3.29

testis:3.22

heart:1.87

muscle:1.53

esophagus:-

stomach:-

intestine:-

colon:2.74

liver/hepato:2.83

lung:2.54

bladder:-

kidney:3.60

pituitary:-

thyroid/parathyroid:3.25

adrenal gland:3.62

pancreas:-

breast:3.31

salivary:-

IDs

Refseq ID	NM_003824
Gene ID	8772
Unigene ID	-
Probe set ID	202535_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000168040
GTEx ID	ENSG00000168040

Orthologous Gene

Mouse[1]	NM_010175
Rat [0]

Chromosomal Region

11q13.3 [70,049,269 - 70,053,496]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_228 [5,001 - 9,240]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000488	Death
IPR001875	Death effector
IPR011029	DEATH-like

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0006915	apoptosis
GO:0071260	cellular response to mechanical stimulus
GO:0051607	defense response to virus
GO:0008625	induction of apoptosis via death domain receptors
GO:0045087	innate immune response
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0070265	necrotic cell death
GO:0043065	positive regulation of apoptosis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032757	positive regulation of interleukin-8 production
GO:0045862	positive regulation of proteolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0032760	positive regulation of tumor necrosis factor production
GO:0060340	positive regulation of type I interferon-mediated signaling pathway
GO:0051291	protein heterooligomerization
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0019048	virus-host interaction

Cellular Component

GO:0031265	CD95 death-inducing signaling complex
GO:0005829	cytosol
GO:0031264	death-inducing signaling complex
GO:0045121	membrane raft
GO:0043005	neuron projection

Molecular Function

GO:0005123	death receptor binding
GO:0042802	identical protein binding
GO:0002020	protease binding
GO:0005515	protein binding
GO:0005164	tumor necrosis factor receptor binding
GO:0032813	tumor necrosis factor receptor superfamily binding

Fas (TNFRSF6)-associated via death domain

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function