aldehyde dehydrogenase 1 family, member A2

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Synonym

Retinaldehyde-specific dehydrogenase type 2, RalDH2, MGC26444, ALDH1A2, RALDH(II), Aldehyde dehydrogenase family 1 member A2, aldehyde dehydrogenase 1 family, member A2, RALDH2, RALDH2-T, Retinal dehydrogenase 2, RALDH 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.60 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:23.50 artery/aorta:30 vein:- lymphnode:40.40 peripheral blood:54.70 spleen:18.90 thymus:38.70 bone marrow:19.70 adipose:40.30 bone:12.80 skin:28.80
GeneChip cerebrum:4.82 cerebellum:4.99 brain stem:4.68 corpus callosum/glia:4.72 pineal gland:- peripheral nerve:5.73 spine:5.38 retina:- eye:- artery/aorta:6.29 vein:6.07 lymphnode:4.65 peripheral blood:- spleen:5.26 thymus:4.95 bone marrow:4.66 adipose:6.55 bone:- skin:5.45
CAGE cerebrum:0.58 cerebellum:- brain stem:0.78 corpus callosum/glia:0.85 pineal gland:1.27 peripheral nerve:- spine:1.12 retina:- eye:- artery/aorta:2.43 vein:2.33 lymphnode:0.80 peripheral blood:- spleen:1.29 thymus:1.54 bone marrow:- adipose:2.46 bone:- skin:-
RNA-seq cerebrum:0.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.48 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.38 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:227.80 placenta:21.90 prostate:281.60 ovary:74.50 testis:333.10 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:31.70        lung:58.70    bladder:- kidney:52 pituitary:463.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:8.96 placenta:6.88 prostate:7.41 ovary:8.19 testis:9.15 heart:7.05 muscle:5.98 esophagus:5.23 stomach:4.80 intestine:5.16 colon:4.82 liver/hepato:4.80 lung:5.78 bladder:- kidney:6.78 pituitary:7.47 thyroid/parathyroid:4.72 adrenal gland:5.66 pancreas:4.76 breast:6.43 salivary:5.24
CAGE uterus:4.06 placenta:3.00 prostate:3.33 ovary:3.12 testis:4.28 heart:2.79 muscle:1.52 esophagus:1.62 stomach:- intestine:0.93 colon:1.26     liver/hepato:1.69    lung:2.45 bladder:1.66 kidney:2.67 pituitary:3.20 thyroid/parathyroid:0.90 adrenal gland:- pancreas:0.58 breast:2.41 salivary:1.67
RNA-seq uterus:- placenta:- prostate:0.92 ovary:0.44 testis:1.89 heart:0.00 muscle:0.14 esophagus:- stomach:- intestine:- colon:0.29     liver/hepato:0.04        lung:0.68    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.36 adrenal gland:0.00 pancreas:- breast:0.03 salivary:-

Gene Information

IDs

Refseq ID NM_170696
Gene ID 8854
Unigene ID Hs.643455
Probe set ID 207016_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000128918
GTEx ID ENSG00000128918

Orthologous Gene

Mouse[1]  NM_009022
Rat [0]  

Chromosomal Region

15q21.3  [58,245,622  -  58,358,616]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8663198
8797830
9819382
10192400
11953746
12477932
14702039
14718574
15489334
16166285
16237707
16368932
17266347
18029348
18495959
19343046
19478994
19609347
19703508
19886994
20308937
20375987
20379614
20450613
21139048
21890473
22505724
22930583
23507523
23833249
24121790
24524833
24728293
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0042904  9-cis-retinoic acid biosynthetic process
GO:0009952  anterior/posterior pattern formation
GO:0001568  blood vessel development
GO:0048738  cardiac muscle tissue development
GO:0071300  cellular response to retinoic acid
GO:0009855  determination of bilateral symmetry
GO:0031076  embryonic camera-type eye development
GO:0035115  embryonic forelimb morphogenesis
GO:0048566  embryonic gut development
GO:0060324  face development
GO:0003007  heart morphogenesis
GO:0030902  hindbrain development
GO:0001822  kidney development
GO:0001889  liver development
GO:0030324  lung development
GO:0007494  midgut development
GO:0016331  morphogenesis of embryonic epithelium
GO:0008285  negative regulation of cell proliferation
GO:0014032  neural crest cell development
GO:0021915  neural tube development
GO:0030182  neuron differentiation
GO:0031016  pancreas development
GO:0021983  pituitary gland development
GO:0043065  positive regulation of apoptosis
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0009954  proximal/distal pattern formation
GO:0001936  regulation of endothelial cell proliferation
GO:0034097  response to cytokine stimulus
GO:0032355  response to estradiol stimulus
GO:0033189  response to vitamin A
GO:0042574  retinal metabolic process
GO:0042573  retinoic acid metabolic process
GO:0048384  retinoic acid receptor signaling pathway
GO:0042572  retinol metabolic process
GO:0006776  vitamin A metabolic process

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0004028  3-chloroallyl aldehyde dehydrogenase activity
GO:0016918  retinal binding
GO:0001758  retinal dehydrogenase activity