B-cell CLL/lymphoma 10

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Synonym

B-cell lymphoma/leukemia 10, mE10, CARMEN, Cellular-E10, CLAP, CARD-like apoptotic protein, CIPER, c-E10, Mammalian CARD-containing adapter molecule E10, Cellular homolog of vCARMEN, Bcl-10, cCARMEN, hCLAP, BCL10, B-cell CLL/lymphoma 10, CARD-containing molecule enhancing NF-kappa-B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:- artery/aorta:179.90 vein:66.60 lymphnode:70.80 peripheral blood:18.20 spleen:18.90 thymus:- bone marrow:39.40 adipose:- bone:- skin:9.60
GeneChip cerebrum:5.23 cerebellum:5.27 brain stem:5.10 corpus callosum/glia:5.37 pineal gland:- peripheral nerve:5.54 spine:5.58 retina:- eye:- artery/aorta:6.07 vein:5.96 lymphnode:6.58 peripheral blood:- spleen:7.05 thymus:6.62 bone marrow:5.68 adipose:6.18 bone:- skin:6.54
CAGE cerebrum:2.82 cerebellum:- brain stem:2.80 corpus callosum/glia:3.01 pineal gland:2.83 peripheral nerve:- spine:3.05 retina:- eye:- artery/aorta:3.52 vein:3.57 lymphnode:4.03 peripheral blood:- spleen:3.87 thymus:3.67 bone marrow:- adipose:3.82 bone:- skin:-
RNA-seq cerebrum:1.69 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.29 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.67 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:10.90 prostate:- ovary:74.50 testis:43.30 heart:12.80 muscle:- esophagus:- stomach:21.20 intestine:32.40 colon:25.40     liver/hepato:21.10        lung:24.40    bladder:125.60 kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:102.20 salivary:-
GeneChip uterus:6.77 placenta:6.18 prostate:7.03 ovary:6.67 testis:5.83 heart:5.81 muscle:5.21 esophagus:7.24 stomach:6.53 intestine:6.18 colon:7.20 liver/hepato:5.68 lung:6.88 bladder:- kidney:6.22 pituitary:5.36 thyroid/parathyroid:6.35 adrenal gland:6.04 pancreas:5.21 breast:6.60 salivary:5.88
CAGE uterus:3.75 placenta:3.37 prostate:3.52 ovary:3.38 testis:3.29 heart:3.30 muscle:2.33 esophagus:4.27 stomach:- intestine:4.21 colon:4.01     liver/hepato:3.22    lung:4.00 bladder:3.66 kidney:3.40 pituitary:2.95 thyroid/parathyroid:3.32 adrenal gland:- pancreas:3.20 breast:3.99 salivary:3.30
RNA-seq uterus:- placenta:- prostate:2.83 ovary:2.66 testis:2.73 heart:1.60 muscle:1.42 esophagus:- stomach:- intestine:- colon:2.77     liver/hepato:1.90        lung:3.52    bladder:- kidney:2.97 pituitary:- thyroid/parathyroid:2.20 adrenal gland:2.67 pancreas:- breast:2.95 salivary:-

Gene Information

IDs

Refseq ID NM_003921
Gene ID 8915
Unigene ID Hs.193516
Probe set ID 205263_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000142867
GTEx ID ENSG00000142867

Orthologous Gene

Mouse[3]  NM_009740
Rat[1]  NM_031328

Chromosomal Region

1p22.3  [85,731,931  -  85,743,771]

Gene Family (Interpro ID)

IPR001315  Caspase Recruitment
IPR011029  DEATH-like

Link to Pubmed  (Pubmed ID)

1040062
8813110
9989495
10187770
10187771
10187815
10319863
10364242
10380921
10400625
10753917
11021819
11053425
11090634
11113112
11163238
11259443
11262391
11278692
11356195
11387339
11466612
11472070
11830492
11836626
11960389
12017308
12154360
12477932
12761501
14523480
14638696
14674990
14695475
15082780
15122200
15125833
15184390
15207693
15213237
15489334
15637807
15878976
16123224
16127295
16186825
16229939
16280327
16341151
16356855
16395405
16647297
16712791
16775419
16785131
16809782
16831874
16920630
17047224
17052756
17095757
17101977
17179215
17189706
17199743
17213322
17287217
17353931
17363905
17371994
17468049
17502353
17540779
17893875
17948050
18223652
18231929
18252714
18287044
18307945
18346354
18349075
18625728
18806265
18949449
19035248
19112107
19279678
19309400
19322201
19336552
19444310
19573080
19593445
19690445
19709433
19773279
19815501
19897484
20164171
20237496
20439115
20466000
20551178
20695076
21048031
21406399
21513986
21674474
21700900
21896478
21988832
22474286
22547678
22564715
22579587
22708078
22812606
22818167
23153494
23530562
23661444
23690623
23784377
24074955
24130731
24250222
24732096

Gene Ontology  (GO ID)

Biological Process

GO:0002250  adaptive immune response
GO:0008219  cell death
GO:0006921  cell structure disassembly during apoptosis
GO:0006968  cellular defense response
GO:0071260  cellular response to mechanical stimulus
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0016064  immunoglobulin mediated immune response
GO:0045087  innate immune response
GO:0042226  interleukin-6 biosynthetic process
GO:0042109  lymphotoxin A biosynthetic process
GO:0002906  negative regulation of mature B cell apoptosis
GO:0001843  neural tube closure
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045416  positive regulation of interleukin-8 biosynthetic process
GO:0032765  positive regulation of mast cell cytokine production
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0042327  positive regulation of phosphorylation
GO:0031398  positive regulation of protein ubiquitination
GO:0050870  positive regulation of T cell activation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0051260  protein homooligomerization
GO:0051259  protein oligomerization
GO:0050856  regulation of T cell receptor signaling pathway
GO:0042221  response to chemical stimulus
GO:0009620  response to fungus
GO:0002237  response to molecule of bacterial origin
GO:0050852  T cell receptor signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0032449  CBM complex
GO:0005737  cytoplasm
GO:0005881  cytoplasmic microtubule
GO:0005829  cytosol
GO:0001772  immunological synapse
GO:0046696  lipopolysaccharide receptor complex
GO:0005764  lysosome
GO:0045121  membrane raft
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0042101  T cell receptor complex

Molecular Function

GO:0019899  enzyme binding
GO:0019209  kinase activator activity
GO:0019900  kinase binding
GO:0051059  NF-kappaB binding
GO:0002020  protease binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0043422  protein kinase B binding
GO:0019901  protein kinase binding
GO:0043621  protein self-association
GO:0003713  transcription coactivator activity
GO:0008134  transcription factor binding
GO:0043130  ubiquitin binding
GO:0031625  ubiquitin protein ligase binding