activin A receptor, type I

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Synonym

Activin receptor-like kinase 2, Activin receptor type I, ALK2, activin A receptor, type I, TSR-I, TGF-B superfamily receptor type I, Activin receptor type-1 precursor, SKR1, ACTRI, Serine/threonine-protein kinase receptor R1, ACTR-I, ACVRLK2, ACVR1, ALK-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:32 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:58.80 artery/aorta:179.90 vein:- lymphnode:10.10 peripheral blood:18.20 spleen:18.90 thymus:- bone marrow:19.70 adipose:- bone:25.60 skin:33.60
GeneChip cerebrum:5.69 cerebellum:5.26 brain stem:5.90 corpus callosum/glia:5.72 pineal gland:- peripheral nerve:6.40 spine:6.03 retina:- eye:- artery/aorta:6.47 vein:7.07 lymphnode:5.63 peripheral blood:- spleen:5.63 thymus:5.13 bone marrow:4.48 adipose:6.73 bone:- skin:6.47
CAGE cerebrum:3.15 cerebellum:- brain stem:3.08 corpus callosum/glia:2.83 pineal gland:4.43 peripheral nerve:- spine:3.35 retina:- eye:- artery/aorta:4.01 vein:3.27 lymphnode:3.10 peripheral blood:- spleen:2.93 thymus:2.66 bone marrow:- adipose:3.45 bone:- skin:-
RNA-seq cerebrum:2.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.54 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.71 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:18.20 prostate:- ovary:37.30 testis:4.30 heart:114.90 muscle:20.10 esophagus:- stomach:63.70 intestine:- colon:33.90     liver/hepato:21.10        lung:34.20    bladder:- kidney:104 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:97.80 breast:55.80 salivary:-
GeneChip uterus:7.37 placenta:6.78 prostate:6.66 ovary:6.94 testis:5.36 heart:6.50 muscle:6.52 esophagus:5.89 stomach:6.12 intestine:6.55 colon:5.98 liver/hepato:5.73 lung:6.27 bladder:- kidney:6.67 pituitary:6.34 thyroid/parathyroid:7.50 adrenal gland:5.88 pancreas:5.24 breast:7.06 salivary:5.74
CAGE uterus:3.63 placenta:3.22 prostate:3.62 ovary:3.51 testis:2.90 heart:3.80 muscle:2.35 esophagus:3.19 stomach:- intestine:3.17 colon:3.34     liver/hepato:3.25    lung:3.72 bladder:3.54 kidney:3.44 pituitary:3.19 thyroid/parathyroid:3.82 adrenal gland:- pancreas:2.90 breast:4.59 salivary:2.69
RNA-seq uterus:- placenta:- prostate:4.04 ovary:4.25 testis:3.53 heart:3.05 muscle:3.73 esophagus:- stomach:- intestine:- colon:3.63     liver/hepato:2.83        lung:3.46    bladder:- kidney:3.86 pituitary:- thyroid/parathyroid:4.71 adrenal gland:3.39 pancreas:- breast:3.54 salivary:-

Gene Information

IDs

Refseq ID NM_001111067
Gene ID 90
Unigene ID Hs.470316
Probe set ID 203935_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000115170
GTEx ID ENSG00000115170

Orthologous Gene

Mouse[6]  NM_001110204, NM_001110205, NM_007394
Rat [0]  

Chromosomal Region

2q24.1  [158,592,958  -  158,732,374]

Gene Family (Interpro ID)

IPR000333  Activin type II receptor
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7791754
7890683
8006002
8242742
8248234
8389764
8397373
8599089
8612709
8622651
8702914
9136927
9267036
9501322
9748228
9872992
9884026
10085121
10583507
10631143
10652350
10665670
11069203
11266516
11969340
12032389
12065756
12477932
12651901
12702211
12857866
15489334
15611116
15761153
16344560
16642017
17351709
17496924
17572636
18019378
18234825
18292470
18436533
18684712
18830232
18854405
18952055
19028479
19064572
19085907
19148527
19299629
19300893
19330033
19335617
19400542
19506109
19543505
19574343
19736306
19758997
19796185
19896889
19929436
19996292
20011542
20463014
20577760
20634197
20663871
20677014
20716560
20734064
20736820
21248739
21297076
21377447
21617230
21668474
21791611
21878751
22630080
22748444
22884369
22949078
22971142
22977237
23142694
23169291
23227223
23260810
23455153
24047559
24347165
24705250
24705251
24705252
24705254
24850914

Gene Ontology  (GO ID)

Biological Process

GO:0032924  activin receptor signaling pathway
GO:0002526  acute inflammatory response
GO:0003289  atrial septum primum morphogenesis
GO:0030509  BMP signaling pathway
GO:0060923  cardiac muscle cell fate commitment
GO:0071385  cellular response to glucocorticoid stimulus
GO:0007368  determination of left/right symmetry
GO:0003143  embryonic heart tube morphogenesis
GO:0000082  G1/S transition of mitotic cell cycle
GO:0001702  gastrulation with mouth forming second
GO:0007281  germ cell development
GO:0001701  in utero embryonic development
GO:0001707  mesoderm formation
GO:0003183  mitral valve morphogenesis
GO:0032926  negative regulation of activin receptor signaling pathway
GO:0009968  negative regulation of signal transduction
GO:0001755  neural crest cell migration
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0001569  patterning of blood vessels
GO:0018107  peptidyl-threonine phosphorylation
GO:0060037  pharyngeal system development
GO:0030501  positive regulation of bone mineralization
GO:0045669  positive regulation of osteoblast differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0030278  regulation of ossification
GO:0048641  regulation of skeletal muscle tissue development
GO:0051145  smooth muscle cell differentiation
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0001655  urogenital system development

Cellular Component

GO:0048179  activin receptor complex
GO:0045177  apical part of cell
GO:0005887  integral to plasma membrane

Molecular Function

GO:0048185  activin binding
GO:0016361  activin receptor activity, type I
GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0017046  peptide hormone binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0050431  transforming growth factor beta binding
GO:0005025  transforming growth factor beta receptor activity, type I
GO:0004675  transmembrane receptor protein serine/threonine kinase activity