NLR family, pyrin domain containing 12

 jump to detail

Synonym

PYPAF7, Regulated by nitric oxide, NALP12, Monarch-1, RNO, NACHT, leucine rich repeat and PYD containing 12, RNO2, NACHT, LRR and PYD-containing protein 12, PYRIN-containing APAF1-like protein 7

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:72.90 spleen:18.90 thymus:- bone marrow:78.70 adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:0.04 cerebellum:- brain stem:0.13 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:0 vein:0.18 lymphnode:1.00 peripheral blood:- spleen:1.67 thymus:0.12 bone marrow:- adipose:0.46 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.12 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:21.20 intestine:- colon:-     liver/hepato:10.60        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip nodata
CAGE uterus:0.37 placenta:0.24 prostate:0.08 ovary:0.37 testis:0.29 heart:0.33 muscle:0.05 esophagus:0.26 stomach:- intestine:0.07 colon:0.39     liver/hepato:0.14    lung:1.34 bladder:0 kidney:0.21 pituitary:0 thyroid/parathyroid:0.12 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.04 ovary:0.05 testis:0.10 heart:0.01 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.05        lung:0.30    bladder:- kidney:0.14 pituitary:- thyroid/parathyroid:0.01 adrenal gland:0.10 pancreas:- breast:0.04 salivary:-

Gene Information

IDs

Refseq ID NM_144687
Gene ID 91662
Unigene ID Hs.631573
Probe set ID -
Ensembl ID ENSG00000142405
GTEx ID ENSG00000142405

Orthologous Gene

Mouse[1]  NM_001033431
Rat [0]  

Chromosomal Region

19q13.42  [54,296,857  -  54,327,648]

Gene Family (Interpro ID)

IPR011029  DEATH-like
IPR004020  Pyrin

Link to Pubmed  (Pubmed ID)

11167794
12019269
12477932
12563287
12759408
14702039
15489334
16203735
16344560
17046979
17237370
17620097
17947705
18160710
18230725
18263805
19234190
19337385
19913121
20403135
20467438
20628086
21048031
21360512
21538323
21978668
22427013
24064030
24338634

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0050710  negative regulation of cytokine secretion
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050728  negative regulation of inflammatory response
GO:0050711  negative regulation of interleukin-1 secretion
GO:0045409  negative regulation of interleukin-6 biosynthetic process
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0031953  negative regulation of protein amino acid autophosphorylation
GO:0009968  negative regulation of signal transduction
GO:0045751  negative regulation of Toll signaling pathway
GO:0050729  positive regulation of inflammatory response
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0045381  regulation of interleukin-18 biosynthetic process
GO:0008588  release of cytoplasmic sequestered NF-kappaB
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0005524  ATP binding
GO:0008656  caspase activator activity
GO:0005515  protein binding