ubiquitin-conjugating enzyme E2L 6

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Synonym

UBE2L6, Ubiquitin carrier protein L6, UBCH8, Retinoic acid-induced gene B protein, Ubiquitin-conjugating enzyme E2 L6, MGC40331, ubiquitin-conjugating enzyme E2L 6, Ubiquitin-protein ligase L6, RIG-B, UbcH8

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:72.30 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:214.70 spine:- retina:- eye:141 artery/aorta:30 vein:66.60 lymphnode:91 peripheral blood:200.40 spleen:18.90 thymus:38.70 bone marrow:78.70 adipose:40.30 bone:12.80 skin:163.20
GeneChip cerebrum:6.91 cerebellum:6.58 brain stem:7.10 corpus callosum/glia:6.74 pineal gland:- peripheral nerve:7.37 spine:7.07 retina:- eye:- artery/aorta:7.14 vein:6.73 lymphnode:7.68 peripheral blood:- spleen:8.15 thymus:8.08 bone marrow:7.04 adipose:7.19 bone:- skin:7.02
CAGE cerebrum:4.10 cerebellum:- brain stem:4.02 corpus callosum/glia:3.87 pineal gland:3.20 peripheral nerve:- spine:4.32 retina:- eye:- artery/aorta:4.47 vein:4.69 lymphnode:4.50 peripheral blood:- spleen:4.82 thymus:4.61 bone marrow:- adipose:4.47 bone:- skin:-
RNA-seq cerebrum:1.66 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.47 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.73 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:109.40 placenta:25.50 prostate:67.60 ovary:260.80 testis:21.60 heart:76.60 muscle:- esophagus:- stomach:85 intestine:32.40 colon:8.50     liver/hepato:31.70        lung:117.30    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:130.10 salivary:-
GeneChip uterus:7.42 placenta:6.30 prostate:7.70 ovary:7.62 testis:6.07 heart:7.08 muscle:6.08 esophagus:6.62 stomach:7.15 intestine:7.03 colon:7.21 liver/hepato:7.52 lung:8.09 bladder:- kidney:6.84 pituitary:6.58 thyroid/parathyroid:6.91 adrenal gland:7.17 pancreas:6.42 breast:7.22 salivary:6.77
CAGE uterus:3.93 placenta:3.86 prostate:4.35 ovary:4.21 testis:3.22 heart:4.03 muscle:3.01 esophagus:4.04 stomach:- intestine:4.15 colon:4.00     liver/hepato:4.75    lung:4.87 bladder:3.79 kidney:3.96 pituitary:3.89 thyroid/parathyroid:4.45 adrenal gland:- pancreas:3.99 breast:4.72 salivary:3.52
RNA-seq uterus:- placenta:- prostate:0.80 ovary:1.72 testis:1.03 heart:0.11 muscle:0.05 esophagus:- stomach:- intestine:- colon:0.38     liver/hepato:0.72        lung:0.45    bladder:- kidney:0.42 pituitary:- thyroid/parathyroid:1.04 adrenal gland:0.91 pancreas:- breast:0.45 salivary:-

Gene Information

IDs

Refseq ID NM_198183
Gene ID 9246
Unigene ID Hs.425777
Probe set ID 201649_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000156587
GTEx ID ENSG00000156587

Orthologous Gene

Mouse[1]  NM_019949
Rat[1]  NM_001024755

Chromosomal Region

11q12.1  [57,319,129  -  57,335,757]

Gene Family (Interpro ID)

IPR000608  Ubiquitin-conjugating enzyme, E2
IPR016135  Ubiquitin-conjugating enzyme/RWD-like

Link to Pubmed  (Pubmed ID)

9153201
10085091
10521492
10558980
10866800
10894956
11078524
11237715
11722579
11786535
12075357
12121982
12477932
14702039
15107846
15131269
15670748
16009940
16344560
16427630
16583136
16709802
17433363
17456438
18029348
18057259
18073335
18583345
19549727
19690564
19928833
20508617
21139048
21628527
21694720
21900206
22037423
22145905
22271254
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0019221  cytokine-mediated signaling pathway
GO:0045087  innate immune response
GO:0032020  ISG15-protein conjugation
GO:0019941  modification-dependent protein catabolic process
GO:0032480  negative regulation of type I interferon production
GO:0006464  protein modification process

Cellular Component

GO:0005829  cytosol

Molecular Function

GO:0042296  ISG15 ligase activity
GO:0005515  protein binding
GO:0004842  ubiquitin-protein ligase activity