integrin beta 1 binding protein 1

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Synonym

ICAP-1, ITGB1BP1, ICAP1A, ICAP1, ICAP1B, integrin beta 1 binding protein 1, ICAP-1B, Integrin beta-1-binding protein 1, DKFZp686K08158, Integrin cytoplasmic domain-associated protein 1, ICAP-1A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:75.80 cerebellum:100.80 brain stem:- corpus callosum/glia:87.50 pineal gland:148.30 peripheral nerve:- spine:- retina:- eye:82.30 artery/aorta:60 vein:133.30 lymphnode:192.10 peripheral blood:36.40 spleen:18.90 thymus:12.90 bone marrow:39.40 adipose:80.70 bone:38.40 skin:67.20
GeneChip cerebrum:7.55 cerebellum:7.31 brain stem:7.72 corpus callosum/glia:6.94 pineal gland:- peripheral nerve:8.03 spine:7.37 retina:- eye:- artery/aorta:7.52 vein:7.17 lymphnode:6.84 peripheral blood:- spleen:6.57 thymus:7.19 bone marrow:6.61 adipose:8.38 bone:- skin:7.62
CAGE cerebrum:3.94 cerebellum:- brain stem:3.88 corpus callosum/glia:3.39 pineal gland:3.39 peripheral nerve:- spine:3.88 retina:- eye:- artery/aorta:3.79 vein:3.88 lymphnode:3.12 peripheral blood:- spleen:3.04 thymus:3.19 bone marrow:- adipose:4.61 bone:- skin:-
RNA-seq cerebrum:4.45 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.23 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.16 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:72.90 prostate:11.30 ovary:37.30 testis:26 heart:51.10 muscle:20.10 esophagus:- stomach:21.20 intestine:32.40 colon:101.80     liver/hepato:10.60        lung:88    bladder:- kidney:72.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:71.10 breast:55.80 salivary:-
GeneChip uterus:7.49 placenta:6.85 prostate:6.90 ovary:7.43 testis:5.90 heart:7.68 muscle:7.06 esophagus:7.12 stomach:6.93 intestine:6.77 colon:6.86 liver/hepato:5.49 lung:7.04 bladder:- kidney:7.35 pituitary:6.18 thyroid/parathyroid:7.09 adrenal gland:6.96 pancreas:5.60 breast:7.57 salivary:6.16
CAGE uterus:3.63 placenta:3.22 prostate:3.49 ovary:3.22 testis:3.00 heart:4.22 muscle:3.29 esophagus:3.63 stomach:- intestine:2.78 colon:3.49     liver/hepato:2.79    lung:3.35 bladder:3.53 kidney:3.67 pituitary:2.94 thyroid/parathyroid:3.33 adrenal gland:- pancreas:3.02 breast:5.33 salivary:2.31
RNA-seq uterus:- placenta:- prostate:4.78 ovary:4.16 testis:4.12 heart:4.19 muscle:3.60 esophagus:- stomach:- intestine:- colon:5.18     liver/hepato:2.82        lung:3.55    bladder:- kidney:4.76 pituitary:- thyroid/parathyroid:3.91 adrenal gland:4.41 pancreas:- breast:6.01 salivary:-

Gene Information

IDs

Refseq ID NM_004763
Gene ID 9270
Unigene ID Hs.467662
Probe set ID 203336_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000119185
GTEx ID ENSG00000119185

Orthologous Gene

Mouse[1]  NM_008403
Rat[1]  NM_001106719

Chromosomal Region

2p25.1  [9,543,604  -  9,563,676]

Gene Family (Interpro ID)

IPR006020  Phosphotyrosine interaction domain
IPR011993  Pleckstrin homology-type

Link to Pubmed  (Pubmed ID)

8619474
8710854
9110174
9281591
9813144
10827173
11741838
11741908
11807099
11854171
11919189
12473654
12477932
14702039
14759258
15166238
15489334
15703214
16341674
16344560
16741948
17133355
17916086
18812969
19124506
20616313
21832049
21900206
21963094
22736399
23317506
23695561

Gene Ontology  (GO ID)

Biological Process

GO:0032148  activation of protein kinase B activity
GO:0031214  biomineral formation
GO:0002043  blood vessel endothelial cell proliferation during sprouting angiogenesis
GO:0030154  cell differentiation
GO:0016477  cell migration
GO:0007160  cell-matrix adhesion
GO:0033622  integrin activation
GO:0007229  integrin-mediated signaling pathway
GO:0051451  myoblast migration
GO:0006933  negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0090051  negative regulation of cell migration involved in sprouting angiogenesis
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0010764  negative regulation of fibroblast migration
GO:0051895  negative regulation of focal adhesion formation
GO:0032091  negative regulation of protein binding
GO:0006469  negative regulation of protein kinase activity
GO:0007219  Notch signaling pathway
GO:0051781  positive regulation of cell division
GO:0008284  positive regulation of cell proliferation
GO:0010595  positive regulation of endothelial cell migration
GO:0051894  positive regulation of focal adhesion formation
GO:0045747  positive regulation of Notch signaling pathway
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0051496  positive regulation of stress fiber formation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0007243  protein kinase cascade
GO:0015031  protein transport
GO:0043113  receptor clustering
GO:0050880  regulation of blood vessel size
GO:0043088  regulation of Cdc42 GTPase activity
GO:0033628  regulation of cell adhesion mediated by integrin
GO:0006351  transcription, DNA-dependent
GO:0035148  tube lumen formation

Cellular Component

GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005925  focal adhesion
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0001726  ruffle

Molecular Function

GO:0005092  GDP-dissociation inhibitor activity
GO:0005178  integrin binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0019901  protein kinase binding
GO:0008565  protein transporter activity