Kruppel-like factor 4 (gut)

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Synonym

GKLF, Epithelial zinc-finger protein EZF, EZF, Kruppel-like factor 4 (gut), Krueppel-like factor 4, KLF4, Gut-enriched krueppel-like factor

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:52.90 artery/aorta:119.90 vein:- lymphnode:30.30 peripheral blood:- spleen:94.50 thymus:- bone marrow:- adipose:121 bone:153.50 skin:33.60
GeneChip cerebrum:5.64 cerebellum:5.39 brain stem:5.70 corpus callosum/glia:6.54 pineal gland:- peripheral nerve:7.71 spine:8.30 retina:- eye:- artery/aorta:9.54 vein:10.05 lymphnode:8.09 peripheral blood:- spleen:10.01 thymus:7.30 bone marrow:6.88 adipose:10.41 bone:- skin:10.93
CAGE cerebrum:2.31 cerebellum:- brain stem:2.60 corpus callosum/glia:3.04 pineal gland:2.17 peripheral nerve:- spine:2.22 retina:- eye:- artery/aorta:4.41 vein:4.16 lymphnode:3.71 peripheral blood:- spleen:4.28 thymus:1.95 bone marrow:- adipose:4.61 bone:- skin:-
RNA-seq cerebrum:1.75 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.39 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:54.60 prostate:56.30 ovary:- testis:82.20 heart:25.50 muscle:- esophagus:- stomach:21.20 intestine:- colon:67.80     liver/hepato:21.10        lung:68.40    bladder:- kidney:- pituitary:- thyroid/parathyroid:655 adrenal gland:- pancreas:88.90 breast:27.90 salivary:-
GeneChip uterus:8.77 placenta:9.65 prostate:9.28 ovary:8.49 testis:8.71 heart:9.10 muscle:7.54 esophagus:10.38 stomach:9.81 intestine:8.24 colon:10.36 liver/hepato:6.53 lung:10.83 bladder:- kidney:7.04 pituitary:5.31 thyroid/parathyroid:9.17 adrenal gland:8.53 pancreas:5.71 breast:9.67 salivary:7.27
CAGE uterus:4.59 placenta:4.87 prostate:3.74 ovary:4.16 testis:3.91 heart:4.42 muscle:3.79 esophagus:4.83 stomach:- intestine:4.87 colon:4.53     liver/hepato:2.75    lung:4.95 bladder:4.09 kidney:2.80 pituitary:1.57 thyroid/parathyroid:2.82 adrenal gland:- pancreas:1.74 breast:4.46 salivary:3.09
RNA-seq uterus:- placenta:- prostate:4.09 ovary:4.60 testis:4.69 heart:3.24 muscle:3.69 esophagus:- stomach:- intestine:- colon:4.00     liver/hepato:1.76        lung:5.12    bladder:- kidney:2.49 pituitary:- thyroid/parathyroid:3.64 adrenal gland:4.34 pancreas:- breast:5.33 salivary:-

IDs

Refseq ID NM_004235
Gene ID 9314
Unigene ID Hs.376206
Probe set ID 221841_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000136826
GTEx ID ENSG00000136826

Orthologous Gene

Mouse[2]  NM_010637
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8702718
8889548
8940147
9218496
9422764
9428642
9443972
9651398
10392904
10431239
10556311
10666450
10749849
10802067
11521200
12034813
12087155
12297499
12427745
12439907
12477932
12581631
12776194
12853980
12901861
12919939
14627709
14670968
14702039
14724568
15031282
15051827
15102675
15489334
15561714
15674344
15740636
15805274
15806166
15937668
16372018
16507986
16632465
17016435
17017123
17135299
17339326
17508399
17614846
17671182
17688680
17762869
17827213
17908689
17932114
18029348
18056793
18157115
18264726
18376139
18390749
18655026
18768922
18977346
19074836
19197145
19327128
19361279
19409607
19458492
19486889
19495417
19503094
19505997
19522013
19541842
19544095
19549847
19696409
19717984
19737957
19751731
19763260
19779097
19816951
19858207
19968965
20030945
20043075
20071344
20072650
20075075
20215880
20305087
20356845
20385121
20442780
20467438
20479568
20519630
20551324
20629177
20699379
20711222
20718868
20727893
20849362
20972454
21075859
21125297
21132436
21159640
21166929
21177849
21219537
21224073
21242971
21252119
21263130
21312053
21412023
21502426
21518959
21531817
21539536
21586797
21652709
21670502
21673106
21674249
21689550
21746878
21832049
21833590
22170051
22170594
22209344
22267480
22282354
22284679
22364861
22384261
22389506
22407433
22430140
22491752
22539002
22592916
22653776
22677193
22766303
22835519
22842522
22854048
22937066
23007394
23023329
23045286
23089465
23097599
23118962
23134681
23160196
23202735
23249717
23275339
23348505
23376074
23384942
23395444
23404370
23418515
23440423
23515309
23585530
23599428
23696417
23722653
23737434
23758499
23861801
23867820
23884216
23921950
23926105
24018236
24030402
24060351
24065485
24156273
24281002
24318462
24388984

Gene Ontology  (GO ID)

Biological Process

GO:0071363  cellular response to growth factor stimulus
GO:0009913  epidermal cell differentiation
GO:0048730  epidermis morphogenesis
GO:0045444  fat cell differentiation
GO:0007500  mesodermal cell fate determination
GO:0043154  negative regulation of caspase activity
GO:0090051  negative regulation of cell migration involved in sprouting angiogenesis
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0034115  negative regulation of heterotypic cell-cell adhesion
GO:0050728  negative regulation of inflammatory response
GO:0045415  negative regulation of interleukin-8 biosynthetic process
GO:0014740  negative regulation of muscle hyperplasia
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0014067  negative regulation of phosphoinositide 3-kinase cascade
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0060761  negative regulation of response to cytokine stimulus
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0046985  positive regulation of hemoglobin biosynthetic process
GO:0051247  positive regulation of protein metabolic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0031077  post-embryonic camera-type eye development
GO:0035166  post-embryonic hemopoiesis
GO:0045595  regulation of cell differentiation
GO:0032526  response to retinoic acid
GO:0019827  stem cell maintenance
GO:0006366  transcription from RNA polymerase II promoter

Cellular Component

GO:0000790  nuclear chromatin
GO:0005667  transcription factor complex

Molecular Function

GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0035014  phosphoinositide 3-kinase regulator activity
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding