solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1

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Synonym

Na(+)/H(+) exchange regulatory cofactor NHE-RF, Regulatory cofactor of Na(+)/H(+) exchanger, NHERF, EBP50, NHERF-1, Sodium-hydrogen exchanger regulatory factor 1, Ezrin-radixin-moesin-binding phosphoprotein 50, SLC9A3R1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.95 cerebellum:7.59 brain stem:6.93 corpus callosum/glia:7.47 pineal gland:- peripheral nerve:7.06 spine:7.36 retina:- eye:- artery/aorta:6.60 vein:6.28 lymphnode:7.60 peripheral blood:- spleen:7.49 thymus:7.40 bone marrow:7.33 adipose:6.83 bone:- skin:6.94
CAGE cerebrum:3.33 cerebellum:- brain stem:3.11 corpus callosum/glia:3.42 pineal gland:2.47 peripheral nerve:- spine:3.04 retina:- eye:- artery/aorta:2.83 vein:2.63 lymphnode:3.66 peripheral blood:- spleen:2.44 thymus:3.45 bone marrow:- adipose:1.79 bone:- skin:-
RNA-seq cerebrum:4.94 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.70 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.65 placenta:6.94 prostate:7.19 ovary:6.78 testis:6.51 heart:6.38 muscle:5.99 esophagus:9.19 stomach:7.23 intestine:7.33 colon:7.54 liver/hepato:7.86 lung:6.66 bladder:- kidney:8.41 pituitary:6.45 thyroid/parathyroid:6.77 adrenal gland:7.43 pancreas:7.09 breast:7.60 salivary:8.67
CAGE uterus:2.50 placenta:2.69 prostate:2.56 ovary:2.33 testis:2.52 heart:2.09 muscle:0.66 esophagus:4.02 stomach:- intestine:4.90 colon:3.80     liver/hepato:4.62    lung:2.72 bladder:1.69 kidney:4.17 pituitary:1.64 thyroid/parathyroid:2.32 adrenal gland:- pancreas:3.78 breast:3.35 salivary:4.32
RNA-seq uterus:- placenta:- prostate:3.55 ovary:3.85 testis:4.43 heart:1.65 muscle:1.03 esophagus:- stomach:- intestine:- colon:2.65     liver/hepato:6.24        lung:3.67    bladder:- kidney:6.21 pituitary:- thyroid/parathyroid:3.37 adrenal gland:3.90 pancreas:- breast:4.24 salivary:-

Gene Information

IDs

Refseq ID NM_004252
Gene ID 9368
Unigene ID -
Probe set ID 201349_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000109062
GTEx ID ENSG00000109062

Orthologous Gene

Mouse[3]  NM_012030
Rat[1]  NM_021594

Chromosomal Region

17q25.1  [72,744,763  -  72,765,498]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7738182
9096337
9314537
9430655
9560162
9613608
9671706
9677412
10446210
10499588
10562288
10748165
10852925
10980202
11046132
11099500
11158634
11285285
11304524
11352585
11526121
11533036
11684085
11882663
11893083
11956211
11967229
12004055
12075354
12080081
12145337
12193606
12369822
12403779
12444018
12471024
12477932
12499563
12615054
12621035
12626493
12651858
12665801
12830000
12881487
12920119
12954600
14507927
14531806
14580213
14604981
14608357
14702039
14744877
15020681
15070904
15146197
15161943
15302935
15342556
15467753
15489334
15523054
15553237
15805108
16129695
16236806
16456542
16519819
16615918
17078868
17081983
17110338
17237149
17242191
17332506
17342744
17593079
17602283
17613530
17884816
17895247
17911601
17982258
18029348
18045536
18184109
18588753
18754678
18784102
19034380
19056867
19073137
19091402
19139211
19165527
19173579
19188335
19234136
19308292
19581308
19591839
19615732
19912366
20012548
20031577
20042604
20140636
20203292
20237154
20395446
20404332
20442317
20562104
20571032
20656684
20736378
20801883
20802536
20937695
21139048
21160026
21170265
21191106
21203899
21496870
21672215
21680517
21707710
21804599
21822312
21832055
21906983
21963094
21971156
21983488
21987572
21988832
21990315
22028271
22053931
22190034
22354994
22366766
22440733
22446018
22466651
22476347
22496422
22506049
22610101
22622406
22628548
22766563
22801783
22863883
22939629
22964850
23118026
23284683
23454118
23483729
23583913
23775624
23985317
24012959
24201803
24583282
24642259
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0007191  activation of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0060158  activation of phospholipase C activity by dopamine receptor signaling pathway
GO:0032782  bile acid secretion
GO:0019933  cAMP-mediated signaling
GO:0030643  cellular phosphate ion homeostasis
GO:0034613  cellular protein localization
GO:0034635  glutathione transport
GO:0030033  microvillus assembly
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0014067  negative regulation of phosphoinositide 3-kinase cascade
GO:0010642  negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0010766  negative regulation of sodium ion transport
GO:0032416  negative regulation of sodium:hydrogen antiporter activity
GO:0006461  protein complex assembly
GO:0044062  regulation of excretion
GO:0045859  regulation of protein kinase activity
GO:0032415  regulation of sodium:hydrogen antiporter activity
GO:0070293  renal absorption
GO:0003096  renal sodium ion transport
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0015629  actin cytoskeleton
GO:0016324  apical plasma membrane
GO:0031526  brush border membrane
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0012505  endomembrane system
GO:0030175  filopodium
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0005902  microvillus
GO:0031528  microvillus membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0001726  ruffle

Molecular Function

GO:0031698  beta-2 adrenergic receptor binding
GO:0008013  beta-catenin binding
GO:0017081  chloride channel regulator activity
GO:0050780  dopamine receptor binding
GO:0070851  growth factor receptor binding
GO:0030165  PDZ domain binding
GO:0019902  phosphatase binding
GO:0005515  protein binding
GO:0043621  protein self-association
GO:0005102  receptor binding